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886992-99-0

中文名稱 886992-99-0
英文名稱 Ac-Gly-BoroPro
CAS 886992-99-0
分子式 C8H15BN2O4
分子量 214.03
MOL 文件 886992-99-0.mol
更新日期 2024/12/03 15:40:35
886992-99-0 結(jié)構(gòu)式 886992-99-0 結(jié)構(gòu)式

基本信息

中文別名
FAP抑制劑(AC-GLY-BOROPRO)
英文別名
Ac-Gly-BoroPro
Ac-Gly-BoroPro?, >98%
Boronic acid, B-[(2S)-1-[2-(acetylamino)acetyl]-2-pyrrolidinyl]-

物理化學(xué)性質(zhì)

密度1.26±0.1 g/cm3(Predicted)
儲存條件Store at -20°C,unstable in solution, ready to use.
溶解度DMSO : ≥ 50 mg/mL (233.61 mM)
酸度系數(shù)(pKa)9.72±0.20(Predicted)
形態(tài)Solid
顏色White to off-white
886992-99-0價格(試劑級)
報(bào)價日期產(chǎn)品編號產(chǎn)品名稱CAS號包裝價格
2024/11/08HY-101801886992-99-0
Ac-Gly-BoroPro
886992-99-01mg2115元
2024/08/19HY-101801886992-99-0
Ac-Gly-BoroPro
886992-99-05mg8100元

常見問題列表

生物活性
Ac-Gly-BoroPro是選擇性的 FAP 抑制劑,Ki 值為23 nM。
靶點(diǎn)

Ki: 23 nM (FAP)

體外研究

FAP has been implicated in cancer; however, its specific role remains elusive because inhibitors that distinguish FAP from other prolyl peptidases like dipeptidyl peptidase-4 (DPP-4) have not been developed. Ac-Gly-BoroPro selectively inhibits FAP relative to other prolyl peptidases. FAP reacts readily with submicromolar concentrations of Ac-Gly-BoroPro, reaching steady state inhibition levels rapidly (K i =23±3 nM). In contrast, DPP-4 requires higher Ac-Gly-BoroPro concentrations for inhibition and a longer time to reach steady state inhibition levels (K i =377±18 nM). Ac-Gly-BoroPro inhibits other prolyl peptidases (DPP-7, DPP-8, DPP-9, prolyl oligopeptidase, and acylpeptide hydrolase) with K i values ranging from 9- to 5400-fold higher than that for FAP inhibition. The N-acyl-linkage in Ac-Gly-BoroPro blocks the N terminus of the inhibitor, making it less nucleophilic and therefore unlikely to cyclize.

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