Phenanthriplatin 価格

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Phenanthriplatin 化學特性,用途語,生産方法

酵素阻害剤

This potent Pt(II) complex (FW = 505.82 g/mol; CAS 1416900-51-0), also known as cis-diamminephenanthridinechloroplatinum(II), penetrates cell membranes either by passive diffusion or carrier-mediated active transport, with the hydrophobic ligand maximizing cellular uptake and making it cytotoxic compared with cisplatin and carbinatoplatin. Its molecular structure was designed with based the X-ray structure of RNA polymerase II (Pol II), when stalled at a monofunctional pyriplatin-DNA adduct. Phenanthriplatin interacts with guanine residues, forming highly potent, monofunctional DNA adducts. While many Pol II elongation complexes stall after successful addition of CTP opposite the phenanthriplatin-dG adduct in an error-free manner, a few slowly undergo error-prone bypass of the phenanthriplatin-dG lesion, a behavior that resembles DNA polymerases that similarly switch from high-fidelity replicative DNA processing (errorfree) to low-fidelity translesion DNA synthesis (error-prone) at DNA damage sites

Phenanthriplatin 上流と下流の製品情報

原材料

準備製品

Phenanthriplatin 生産企業(yè)

名前	電話番號	電子メール	國籍	製品カタログ	優(yōu)位度
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	32161	58
Shanghai Yifei Biotechnology Co. , Ltd.	021-65675885 18964387627	customer_service@efebio.com	China	11974	58
TargetMol Chemicals Inc.	15002134094	marketing@targetmol.cn	China	19703	58

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• 1416900-51-0
• Phenanthriplatin
• cis-[Pt(NH3)2-(phenanthridine)Cl]NO3