(-)-TRANS-(1S,2S)-U-50488 HYDROCHLORIDE POTENT K OPIOID RECEP
- CAS No.
- 114528-79-9
- Chemical Name:
- (-)-TRANS-(1S,2S)-U-50488 HYDROCHLORIDE POTENT K OPIOID RECEP
- Synonyms
- ()-trans-(1S,2S)-U-50488;(-)-U-50488 hydrochloride;(?)-trans-(1S,2S)-U-50488 hydrochloride hydrate;(-)-trans-(1S,2S)-U-50488 hydrate hydrochloride;(-)-TRANS-(1S,2S)-U-50488 HYDROCHLORIDE POTENT K OPIOID RECEP;(-)-TRANS-(1S,2S)-U-50488 HYDROCHLORIDE POTENT K OPIOID RECEP;Benzeneacetamide,3,4-dichloro-N-methyl-N-[(1S,2S)-2-(1-pyrrolidinyl)cyclohexyl]-, hydrochloride(1:1);trans-(1S,2S)-3,4-Dichloro-N-methyl-N-[2-(1-pyrrolidinyl)cyclohexyl]benzeneacetamide hydrochloride hydrate;trans-(1S,2S)-3,4-Dichloro-N-methyl-N-[2-(1-pyrrolidinyl)cyclohexyl]benzeneacetamide hydrate hydrochloride
- CBNumber:
- CB9972973
- Molecular Formula:
- C19H27Cl3N2O
- Molecular Weight:
- 405.79
- MDL Number:
- MFCD00211360
- MOL File:
- 114528-79-9.mol
- MSDS File:
- SDS
(-)-TRANS-(1S,2S)-U-50488 HYDROCHLORIDE POTENT K OPIOID RECEP price More Price(10)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | U111 | (?)-trans-(1S,2S)-U-50488 hydrochloride hydrate solid, ≥98% (HPLC) | 114528-79-9 | 5mg | $127 | 2024-03-01 | Buy |
| Sigma-Aldrich | U111 | (?)-trans-(1S,2S)-U-50488 hydrochloride hydrate solid, ≥98% (HPLC) | 114528-79-9 | 25mg | $420 | 2024-03-01 | Buy |
| Sigma-Aldrich | U111 | (?)-trans-(1S,2S)-U-50488 hydrochloride hydrate solid, ≥98% (HPLC) | 114528-79-9 | 100mg | $508 | 2024-03-01 | Buy |
| Tocris | 0496 | (-)-U-50488hydrochloride ≥99%(HPLC) | 114528-79-9 | 50 | $668 | 2021-12-16 | Buy |
| Tocris | 0496 | (-)-U-50488hydrochloride ≥99%(HPLC) | 114528-79-9 | 10 | $159 | 2021-12-16 | Buy |
(-)-TRANS-(1S,2S)-U-50488 HYDROCHLORIDE POTENT K OPIOID RECEP Chemical Properties,Uses,Production
Uses
(-)-U-50488 Hydrochloride is an analgesic agent used in the protection of ischemia/ischemia reperfusion.
Uses
(?)-trans-(1S,2S)-U-50488 hydrochloride hydrate (U-50488) has been used as a κ-opioid receptor (KOR) agonist has been used to study its effect on the increase of tidal volumes in adult red-eared slider turtles (Trachemys scripta).
Biological Activity
(-)-u-50488 hydrochloride is a selective agonist for κ-opioid receptor [1].the κ-opioid receptor (kor) is a type of opioid receptor for opioid peptide dynorphin and controls addiction. also, kor plays an important role in stress, anxiety, anhedonia, depression and increased drug-seeking behavior.(-)-u-50488 hydrochloride is a selective kor agonist [1]. in isolated rat drg neurons, u-50488 (0.3-40 μm) inhibited voltage-independent ca2+ channel currents. in hela cells that didn’t express kor, u-50488 (20 μm) blocked ca2+ channels [2].in rhesus monkeys, u-50488 exhibited potent antinociceptive activity and produced diuresis [1]. u-50488 enhanced contraction of the rabbit vas deferens induced by electrically with ic50 value of 26.5 nm. in mice, u-50488 impaired motor function with ed50 value of 15.3 mg/kg and reduced spontaneous activity [3]. in adult rats, u-50488 increased the threshold required to maintain self-stimulation responding, a depressive-like effect. while, males were significantly more sensitive than females to the threshold-increasing effects [4].
Biochem/physiol Actions
Potent κ opioid receptor agonist; more potent enantiomer of (±)-trans-U-50488.
storage
Store at RT
References
[1]. tang ah, collins rj. behavioral effects of a novel kappa opioid analgesic, u-50488, in rats and rhesus monkeys. psychopharmacology (berl), 1985, 85(3): 309-314.
[2]. hassan b, ruiz-velasco v. the κ-opioid receptor agonist u-50488 blocks ca2+ channels in a voltage- and g protein-independent manner in sensory neurons. reg anesth pain med, 2013, 38(1): 21-27.
[3]. lu sn, ma sc, zhang kg, et al. comparison of pharmacological profile of selective kappa-opioid agonist k-ii and u-50488. yao xue xue bao, 1991, 26(3): 171-174.
[4]. russell se, rachlin ab, smith kl, et al. sex differences in sensitivity to the depressive-like effects of the kappa opioid receptor agonist u-50488 in rats. biol psychiatry, 2014, 76(3): 213-222.
(-)-TRANS-(1S,2S)-U-50488 HYDROCHLORIDE POTENT K OPIOID RECEP Preparation Products And Raw materials
Raw materials
Preparation Products
(-)-TRANS-(1S,2S)-U-50488 HYDROCHLORIDE POTENT K OPIOID RECEP Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6312 | 58 |
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 52924 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131957 | 58 |
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51456 | 80 |
| Pharmacodia (Beijing) Co.,Ltd | +86-400-851-9921 | sales@pharmacodia.com | China | 2317 | 55 |
| Lynnchem | 86-(0)29-85992781 17792393971 | info@lynnchem.com | China | 4587 | 58 |
| Novachemistry | 44-20819178-90 02081917890 | info@novachemistry.com | United Kingdom | 4381 | 58 |
| Jiangsu aikang biomedical research and development co., LTD | 025-66110311 13155353615 | qzhang@aikonchem.com | China | 15527 | 58 |
| Changzhou Furuisi Biotechnology Co., Ltd | 0519-85524369 | 3477467573@qq.com | China | 8617 | 58 |
| Nantong QuanYi Biotechnology Co., Ltd | 0513-66337626 18051384581 | sales@chemhifuture.com | China | 4988 | 58 |