JTE 952)
- CAS No.
- 1255303-54-8
- Chemical Name:
- JTE 952)
- Synonyms
- JTE 952);JTE-952 (JTE952;Methanone, [3-[4-[(4-cyclopropylphenyl)methoxy]-3-methoxyphenyl]-1-azetidinyl][4-[[(2S)-2,3-dihydroxypropoxy]methyl]-2-pyridinyl]-
- CBNumber:
- CB94844944
- Molecular Formula:
- C30H34N2O6
- Molecular Weight:
- 518.6
- MDL Number:
- MFCD32062805
- MOL File:
- 1255303-54-8.mol
JTE 952) Chemical Properties,Uses,Production
Uses
JTE-952 is a potent, oral active and selective Type II inhibitor of colony stimulating factor-1 receptor (CSF-1R or cFMS, type III receptor tyrosine kinase), with IC50 values of 13 nM and 261 nM for CSF1R and TrkA , respectively. Effective against a mouse collagen-induced model of arthritis[1].
in vivo
JTE-952 (3 mg/kg, p.o. once-daily) treatment reduces the overall progression of the clinical score, including inflammation and bone erosion in mouse model of collagen-induced arthritis (CIA model)[1].
| Animal Model: | Mouse model of collagen-induced arthritis (CIA model)[1]. |
| Dosage: | 3 mg/kg. |
| Administration: | Oral once-daily. |
| Result: | Reduced the overall progression of the clinical score, including inflammation and bone erosion. |
References
[1] Ikegashira K, et al. Optimization of an azetidine series as inhibitors of colony stimulating factor-1 receptor (CSF-1R) Type II to lead to the clinical candidate JTE-952. Bioorg Med Chem Lett. 2019 Apr 1;29(7):873-877. DOI:10.1016/j.bmcl.2019.02.006
JTE 952) Preparation Products And Raw materials
Raw materials
Preparation Products
JTE 952) Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32276 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6312 | 58 |
| TargetMol Chemicals Inc. | support@targetmol.com | United States | 38664 | 58 | |
| Aladdin Scientific | tp@aladdinsci.com | United States | 52924 | 58 | |
| TargetMol Chemicals Inc. | +8613564774135 | zijue.cai@tsbiochem.com | United States | 19906 | 58 |
| TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 24884 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 11973 | 58 |
| RD International Technology Co., Limited | 18024082417 | market@ubiochem.com | China | 9835 | 58 |
| Biosynth Biological Technology (Suzhou) Co Ltd | 51288865780 | sales@biosynth.com | China | 233051 | 58 |
| Adooq Bioscience LLC | 400-025-6535 | sales@adooq.cn | China | 18215 | 58 |
