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ChemicalBook >> CAS DataBase List >>JTE 952)

JTE 952)

CAS No.
1255303-54-8
Chemical Name:
JTE 952)
Synonyms
JTE 952);JTE-952 (JTE952;Methanone, [3-[4-[(4-cyclopropylphenyl)methoxy]-3-methoxyphenyl]-1-azetidinyl][4-[[(2S)-2,3-dihydroxypropoxy]methyl]-2-pyridinyl]-
CBNumber:
CB94844944
Molecular Formula:
C30H34N2O6
Molecular Weight:
518.6
MDL Number:
MFCD32062805
MOL File:
1255303-54-8.mol
Last updated:2025-04-18 09:53:08

JTE 952) Properties

Boiling point 764.1±60.0 °C(Predicted)
Density 1.294±0.06 g/cm3(Predicted)
form Solid
pka 13.54±0.20(Predicted)
color White to off-white

JTE 952) Chemical Properties,Uses,Production

Uses

JTE-952 is a potent, oral active and selective Type II inhibitor of colony stimulating factor-1 receptor (CSF-1R or cFMS, type III receptor tyrosine kinase), with IC50 values of 13 nM and 261 nM for CSF1R and TrkA , respectively. Effective against a mouse collagen-induced model of arthritis[1].

in vivo

JTE-952 (3 mg/kg, p.o. once-daily) treatment reduces the overall progression of the clinical score, including inflammation and bone erosion in mouse model of collagen-induced arthritis (CIA model)[1].

Animal Model:Mouse model of collagen-induced arthritis (CIA model)[1].
Dosage:3 mg/kg.
Administration:Oral once-daily.
Result:Reduced the overall progression of the clinical score, including inflammation and bone erosion.

References

[1] Ikegashira K, et al. Optimization of an azetidine series as inhibitors of colony stimulating factor-1 receptor (CSF-1R) Type II to lead to the clinical candidate JTE-952. Bioorg Med Chem Lett. 2019 Apr 1;29(7):873-877. DOI:10.1016/j.bmcl.2019.02.006

JTE 952) Preparation Products And Raw materials

Raw materials

Preparation Products

JTE 952) Suppliers

Global( 11)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc.
+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32276 58
HANGZHOU CLAP TECHNOLOGY CO.,LTD
86-571-88216897,88216896 13588875226 sales@hzclap.com CHINA 6312 58
TargetMol Chemicals Inc.
support@targetmol.com United States 38664 58
Aladdin Scientific
tp@aladdinsci.com United States 52924 58
TargetMol Chemicals Inc.
+8613564774135 zijue.cai@tsbiochem.com United States 19906 58
TargetMol Chemicals Inc. 4008200310 marketing@tsbiochem.com China 24884 58
Shanghai Yifei Biotechnology Co. , Ltd. 021-65675885 18964387627 customer_service@efebio.com China 11973 58
RD International Technology Co., Limited 18024082417 market@ubiochem.com China 9835 58
Biosynth Biological Technology (Suzhou) Co Ltd 51288865780 sales@biosynth.com China 233051 58
Adooq Bioscience LLC 400-025-6535 sales@adooq.cn China 18215 58

View Lastest Price from JTE 952) manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
JTE-952 pictures 2024-10-24 JTE-952
1255303-54-8
US $3100.00-1680.00 / mg 10g TargetMol Chemicals Inc.
  • JTE-952 pictures
  • JTE-952
    1255303-54-8
  • US $3100.00-1680.00 / mg
  • TargetMol Chemicals Inc.
JTE 952) JTE-952 (JTE952 Methanone, [3-[4-[(4-cyclopropylphenyl)methoxy]-3-methoxyphenyl]-1-azetidinyl][4-[[(2S)-2,3-dihydroxypropoxy]methyl]-2-pyridinyl]- 1255303-54-8