天堂网亚洲,天天操天天搞,91视频高清,菠萝蜜视频在线观看入口,美女视频性感美女视频,95丝袜美女视频国产,超高清美女视频图片

ChemicalBook >> CAS DataBase List >>RTI-13951-33

RTI-13951-33

CAS No.
2244884-08-8
Chemical Name:
RTI-13951-33
Synonyms
RTI-13951-33;RTI1395133,RTI 13951 33;(1R,2R)-N-((2R,3R)-2-Amino-3-methoxybutyl)-N-(4'-(methoxymethyl)-[1,1'-biphenyl]-4-yl)-2-(pyridin-2-yl)cyclopropane-1-carboxamide;Cyclopropanecarboxamide, N-[(2R,3R)-2-amino-3-methoxybutyl]-N-[4'-(methoxymethyl)[1,1'-biphenyl]-4-yl]-2-(2-pyridinyl)-, (1R,2R)-
CBNumber:
CB94668465
Molecular Formula:
C28H33N3O3
Molecular Weight:
459.58
MDL Number:
MFCD31807609
MOL File:
2244884-08-8.mol
Last updated:2025-04-18 09:53:08

RTI-13951-33 Properties

Boiling point 637.3±55.0 °C(Predicted)
Density 1.181±0.06 g/cm3(Predicted)
storage temp. Store at -20°C
solubility Soluble in DMSO
pka 6.99±0.13(Predicted)

RTI-13951-33 Chemical Properties,Uses,Production

Uses

RTI-13951-33 is a potent, selective, and brain-penetrant GPR88 agonist, with an EC50 of 25 nM in GPR88 cAMP functional assay. RTI-13951-33 reduces alcohol reinforcement and intake behaviors in rats[1].

in vivo

RTI-13951-33 (10 mg/kg, i.p.) has sufficient brain penetration, with t1/2 of 48 min and 87 min in rat plasma and brain[1].
RTI-13951-33 (10 and 20 mg/kg, i.p.) dose-dependently decreases alcohol lever responses in a rat model of alcohol self-administration[1].

References

[1] Jin C, et al. Discovery of a Potent, Selective, and Brain-Penetrant Small Molecule that Activates the Orphan Receptor GPR88 and Reduces Alcohol Intake. J Med Chem. 2018 Aug 9;61(15):6748-6758. DOI:10.1021/acs.jmedchem.8b00566

RTI-13951-33 Preparation Products And Raw materials

Raw materials

Preparation Products

RTI-13951-33 Suppliers

Global( 14)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32275 58
Nantong HI-FUTURE Biology Co., Ltd. 		+undefined18051384581 sales@chemhifuture.com China 3135 58
TargetMol Chemicals Inc. 		support@targetmol.com United States 38664 58
TargetMol Chemicals Inc. 		+8613564774135 zijue.cai@tsbiochem.com United States 19905 58
Shanghai hongqu biomedical technology co. LTD 88888888888 hongquchem@qq.com China 5132 58
cjbscvictory 13348960310 13348960310 3003867561@qq.com China 10523 58
Nantong Hi-Future Biotechnology Co., Ltd 18051384581 sales@chemhifuture.com China 3018 58
Beijing Jin Ming Biotechnology Co., Ltd. 010-60605840 15801484223; psaitong@jm-bio.com China 29772 58
TargetMol Chemicals Inc. 4008200310 marketing@tsbiochem.com China 24875 58
Shanghai Tachizaki Biomedical Research Center 18014399201 sales@chemlab-tachizaki.com China 2672 58

View Lastest Price from RTI-13951-33 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
RTI-13951-33 pictures 2024-10-28 RTI-13951-33
2244884-08-8
 US $2380.00-1820.00 / mg 10g TargetMol Chemicals Inc.
  • RTI-13951-33 pictures
  • RTI-13951-33
    2244884-08-8
  • US $2380.00-1820.00 / mg
  • TargetMol Chemicals Inc.
RTI-13951-33 RTI1395133,RTI 13951 33 Cyclopropanecarboxamide, N-[(2R,3R)-2-amino-3-methoxybutyl]-N-[4'-(methoxymethyl)[1,1'-biphenyl]-4-yl]-2-(2-pyridinyl)-, (1R,2R)- (1R,2R)-N-((2R,3R)-2-Amino-3-methoxybutyl)-N-(4'-(methoxymethyl)-[1,1'-biphenyl]-4-yl)-2-(pyridin-2-yl)cyclopropane-1-carboxamide 2244884-08-8