EC-17 (disodiuM salt)
- CAS No.
- 910661-33-5
- Chemical Name:
- EC-17 (disodiuM salt)
- Synonyms
- EC-17 (disodiuM salt);QXZUFPLOUOSMBT-ARIINYJRSA-N;N2-[4-[[(2-Amino-1,4-dihydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-N-[2-[[[(3',6'-dihydroxy-3-oxospiro[isobenzofuran-1(3H),9'-[9H ]xanthen]-5-yl)amino]thioxomethyl]amino]ethyl]-L-glutamine disodium salt;5-[[[[2-[[(4S)-4-[[4-[[(2-Amino-1,4-dihydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]amino]-4-carboxy-1-oxobutyl]amino]ethyl]amino]thioxomethyl]amino]-2-(6-hydroxy-3-oxo-3H-xanthen-9-yl)benzoic acid sodium salt
- CBNumber:
- CB92667266
- Molecular Formula:
- C42H34N10Na2O10S
- Molecular Weight:
- 916.8249
- MDL Number:
- MFCD25976616
- MOL File:
- 910661-33-5.mol
EC-17 (disodiuM salt) Chemical Properties,Uses,Production
Uses
EC-17 (disodium salt) is a folate receptor alpha (FRα) targeting contrast agent with fluorescent properties in the visible light spectrum. The peak excitation and emission wavelengths of EC-17 are 470/520?nm.
in vivo
The mean fluorescence signal from the animals injected with EC-17 to be 42,234 ± 12,234 au[1]. Fluorescence microscopy for folate-FITC shows a strong signal in all malignant tumors with FR-α expression and no signal in FR-α–negative malignant or benign lesions[2].
References
[1] Tummers QR, et al. Intraoperative imaging of folate receptor alpha positive ovarian and breast cancer using the tumor specific agent EC17. Oncotarget. 2016 May 31;7(22):32144-55. DOI:10.18632/oncotarget.8282
EC-17 (disodiuM salt) Preparation Products And Raw materials
Raw materials
Preparation Products
EC-17 (disodiuM salt) Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32274 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 52924 | 58 | |
| NCE Biomedical Co.,Ltd. | 4000-027-021 |24 +86-13986109188 | +86-15623472865 | +81-08033611988 | China | 1493 | 55 | |
| SPIRO PHARMA | eric_feng1954@126.com | China | 9248 | 55 | |
| RD International Technology Co., Limited | 18024082417 | market@ubiochem.com | China | 9835 | 58 |
| Biosynth Biological Technology (Suzhou) Co Ltd | 51288865780 | sales@biosynth.com | China | 233051 | 58 |
| Supplier | Advantage |
|---|---|
| TargetMol Chemicals Inc. | 58 |
| Aladdin Scientific | 58 |
| NCE Biomedical Co.,Ltd. | 55 |
| SPIRO PHARMA | 55 |
| RD International Technology Co., Limited | 58 |
| Biosynth Biological Technology (Suzhou) Co Ltd | 58 |