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ChemicalBook >> CAS DataBase List >>(-)-Gossypol

(-)-Gossypol

CAS No.
90141-22-3
Chemical Name:
(-)-Gossypol
Synonyms
CS-619;C:C&B61;(R)-Gossypol;(-)-Gossypol;AT 101, >=98%;GOSSYPOL，AT101;(R)-(-)-Gossypol;GOSSYPOL 90141-22-3;(-)-Gossypol USP/EP/BP;DL-gossypol acetic acid
CBNumber:
CB91437592
Molecular Formula:
C30H30O8
Molecular Weight:
518.55
MDL Number:
MFCD00017352
MOL File:
90141-22-3.mol
MSDS File:
SDS
Last updated:2023-06-30 15:45:59

(-)-Gossypol Properties

Melting point 166-167℃
alpha D28 -386 to -390° (c = 0.5 g/100 g soln in CHCl3)
Boiling point 707.9±55.0 °C(Predicted)
Density 1.403
storage temp. -20°C
solubility DMSO: soluble15mg/mL, clear
form powder
pka 7.15±0.50(Predicted)
color white to light brown
optical activity [α]/D -350 to -365°, c = 0.3 (CDCl3)
Stability Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
FDA UNII 8DY2X8LXW4
NCI Drug Dictionary R-(-)-gossypol acetic acid

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302
Precautionary statements  P280-P305+P351+P338
WGK Germany  3

(-)-Gossypol price More Price(10)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TRC A790545 AT101 90141-22-3 5mg $130 2021-12-16 Buy
BroadPharm BP-25397 AT101 98% 90141-22-3 25mg $200 2021-12-16 Buy
ApexBio Technology A3196 AT-101 90141-22-3 10mg $105 2021-12-16 Buy
BroadPharm BP-25397 AT101 98% 90141-22-3 50mg $300 2021-12-16 Buy
ApexBio Technology A3196 AT-101 90141-22-3 50mg $330 2021-12-16 Buy
Product number Packaging Price Buy
A790545 5mg $130 Buy
BP-25397 25mg $200 Buy
A3196 10mg $105 Buy
BP-25397 50mg $300 Buy
A3196 50mg $330 Buy

(-)-Gossypol Chemical Properties,Uses,Production

Description

AT-101 (90141-22-3) is a small molecule mimic of the BH3 domain of cellular Bcl-2 inhibitors which interferes with the function of Bcl-2-family antiapoptotic proteins. AT-101 induces apoptosis in drug-resistant multiple myeloma cell lines. Apoptosis is activated by the mitochondrial pathway. Cell permeable.

Uses

AT-101 is a BH3 mimetic known to be a potent inhibitor of antiapoptotic Bcl-2 family members.

Biological Activity

R-(-)-enantiomer of gossypol (Gossypol). Mimics the BH3 domains of Bcl-2, Bcl-XL and Mcl-1. Disrupts heterodimerization of Bcl-2 with proapoptotic family members. Induces apoptosis in vitro through activation of caspase-9; cytotoxic to multiple myeloma and drug-resistant cell lines. Delays onset of androgen-independent growth of VCaP prostate cancer xenografts in vivo .

Biochem/physiol Actions

AT101 [R-(-)-enantiomer of gossypol] is an orally available and well-tolerated natural BH3-mimetic that activates Bax and also induces mitochondrial Smac release. AT101 has shown anti-tumor activity as a single agent and in combination with standard anticancer drugs in a variety of tumor models. AT101 induced apoptosis in chemoresistant ovarian cancer cells.

storage

Store at -20°C

References

1) Kline et al. (2008), R-(-)-gossypol (AT-101) activates programmed cell death in multiple myeloma cells; Exp. Hematol., 36 568 2) Balakrishnan et al. (2009), AT-101 induces apoptosis in CLL B cells and overcomes stromal cell-mediated Mcl-1 induction and drug resistance; Blood, 113 149

(-)-Gossypol Preparation Products And Raw materials

Raw materials

Preparation Products

(-)-Gossypol Suppliers

Global( 55)Suppliers
Supplier Tel Email Country ProdList Advantage
Shanghai UCHEM Inc. 		+862156762820 +86-13564624040 sales@myuchem.com China 7712 58
Shaanxi Dideu Medichem Co. Ltd 		+86-029-89586680 +86-18192503167 1026@dideu.com China 7724 58
AFINE CHEMICALS LIMITED 		+86-0571-85134551 sales@afinechem.com China 15352 58
Zhejiang J&C Biological Technology Co.,Limited 		+1-2135480471 +1-2135480471 sales@sarms4muscle.com China 10473 58
Henan Aochuang Chemical Co.,Ltd. 		+86-0371-63689365 +8618638391208 sales@aochuangchem.com China 9245 58
TargetMol Chemicals Inc. 		support@targetmol.com United States 38631 58
Amadis Chemical Company Limited 		571-89925085 sales@amadischem.com China 131957 58
Shanghai Boyle Chemical Co., Ltd. sales@boylechem.com China 2922 55
3B Pharmachem (Wuhan) International Co.,Ltd. 821-50328103-801 18930552037 3bsc@sina.com China 15839 69
Chembest Research Laboratories Limited +86-21-20908456 sales@BioChemBest.com China 6005 61

View Lastest Price from (-)-Gossypol manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
(-)-Gossypol pictures 2024-04-17 (-)-Gossypol
90141-22-3
 US $1.10 / g 1g 99.0% min 100 tons min Shaanxi Dideu Medichem Co. Ltd
(-)-Gossypol pictures 2022-09-23 (-)-Gossypol
90141-22-3
 US $0.00-0.00 / kg 1kg 98% 1Ton Henan Aochuang Chemical Co.,Ltd.
  • (-)-Gossypol pictures
  • (-)-Gossypol
    90141-22-3
  • US $1.10 / g
  • 99.0% min
  • Shaanxi Dideu Medichem Co. Ltd
  • (-)-Gossypol pictures
  • (-)-Gossypol
    90141-22-3
  • US $0.00-0.00 / kg
  • 98%
  • Henan Aochuang Chemical Co.,Ltd.
AT 101, >=98% DL-gossypol acetic acid (R)-(-)-Gossypol (R)-1,1',6,6',7,7'-Hexahydroxy-3,3'-dimethyl-5,5'-bis(1-methylethyl)-[2,2'-binaphthalene]-8,8'-dicarboxaldehyde (R)-Gossypol R-(-)-gossypol acetic acid GOSSYPOL 90141-22-3 CS-619 (R)-(-)-GOSSYPOL;R-(-)-GOSSYPOL ACETIC ACID C:C&B61 [2,2'-Binaphthalene]-8,8'-dicarboxaldehyde, 1,1',6,6',7,7'-hexahydroxy-3,3'-dimethyl-5,5'-bis(1-methylethyl)-, (2R)- (-)-Gossypol (-)-Gossypol USP/EP/BP GOSSYPOL，AT101 AT 101, Bcl-2 and Mcl-1 inhibitor (BH3-mimetic) 90141-22-3 Inhibitors