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D-Mannitol, 1,4:3,6-dianhydro-2-O-[6-chloro-5-(2',6'-dihydroxy[1,1'-biphenyl]-4-yl)-1H-benzimidazol-2-yl]-

CAS No.
1852451-96-7
Chemical Name:
D-Mannitol, 1,4:3,6-dianhydro-2-O-[6-chloro-5-(2',6'-dihydroxy[1,1'-biphenyl]-4-yl)-1H-benzimidazol-2-yl]-
Synonyms
AMPK activator 8;D-Mannitol, 1,4:3,6-dianhydro-2-O-[6-chloro-5-(2',6'-dihydroxy[1,1'-biphenyl]-4-yl)-1H-benzimidazol-2-yl]-
CBNumber:
CB912589990
Molecular Formula:
C25H21ClN2O6
Molecular Weight:
480.9
MDL Number:
MOL File:
1852451-96-7.mol
Last updated:2025-04-29 09:03:59

D-Mannitol, 1,4:3,6-dianhydro-2-O-[6-chloro-5-(2',6'-dihydroxy[1,1'-biphenyl]-4-yl)-1H-benzimidazol-2-yl]- Properties

Boiling point 795.0±70.0 °C(Predicted)
Density 1.519±0.06 g/cm3(Predicted)
pka 8.79±0.10(Predicted)

D-Mannitol, 1,4:3,6-dianhydro-2-O-[6-chloro-5-(2',6'-dihydroxy[1,1'-biphenyl]-4-yl)-1H-benzimidazol-2-yl]- Chemical Properties,Uses,Production

Uses

AMPK activator 8 (compound 2) is an AMP-activated protein kinase (AMPK)?activator with EC50s of 11, 27, 4, 2, and 4 nM for rAMPK α1β1γ1, rAMPK α2β1γ1, rAMPK α1β2γ1, rAMPK α2β2γ1, rAMPK α2β2γ3, respectively. AMPK activator 8 can be used for the research of?type 2 diabetes[1].

IC 50

AMPK α1β1γ1: 11 nM (EC50); AMPK α2β1γ1: 27 nM (EC50); AMPK α1β2γ1: 4 nM (EC50); AMPK α2β2γ1: 2 nM (EC50)

References

[1] Mathilde Muzerelle, et al. Novel activators of amp-activated protein kinases.WO2016001224A1

D-Mannitol, 1,4:3,6-dianhydro-2-O-[6-chloro-5-(2',6'-dihydroxy[1,1'-biphenyl]-4-yl)-1H-benzimidazol-2-yl]- Preparation Products And Raw materials

Raw materials

Preparation Products

D-Mannitol, 1,4:3,6-dianhydro-2-O-[6-chloro-5-(2',6'-dihydroxy[1,1'-biphenyl]-4-yl)-1H-benzimidazol-2-yl]- Suppliers

Global( 2)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc. 		+8613564774135 zijue.cai@tsbiochem.com United States 19906 58
TargetMol Chemicals Inc. 15002134094 marketing@targetmol.cn China 20036 58

View Lastest Price from D-Mannitol, 1,4:3,6-dianhydro-2-O-[6-chloro-5-(2',6'-dihydroxy[1,1'-biphenyl]-4-yl)-1H-benzimidazol-2-yl]- manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
AMPK activator 8 pictures 2025-04-29 AMPK activator 8
1852451-96-7
 US $1520.00-1980.00 / mg 10g TargetMol Chemicals Inc.
D-Mannitol, 1,4:3,6-dianhydro-2-O-[6-chloro-5-(2',6'-dihydroxy[1,1'-biphenyl]-4-yl)-1H-benzimidazol-2-yl]- AMPK activator 8 1852451-96-7