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ChemicalBook >> CAS DataBase List >>1H-Indol-5-ol, 1-[[4-[2-(hexahydro-1H-azepin-1-yl)ethoxy]phenyl]methyl]-2-(4-hydroxyphenyl)-3-methyl-, hydrochloride (1:1)

1H-Indol-5-ol, 1-[[4-[2-(hexahydro-1H-azepin-1-yl)ethoxy]phenyl]methyl]-2-(4-hydroxyphenyl)-3-methyl-, hydrochloride (1:1)

CAS No.
198480-56-7
Chemical Name:
1H-Indol-5-ol, 1-[[4-[2-(hexahydro-1H-azepin-1-yl)ethoxy]phenyl]methyl]-2-(4-hydroxyphenyl)-3-methyl-, hydrochloride (1:1)
Synonyms
CS-1416;Bazedoxifene HCl;Bazedoxifene acetate HCL;Bazedoxifene hydrochloride;Bazedoxifene (WAY-140424) HCl;1H-Indol-5-ol, 1-[[4-[2-(hexahydro-1H-azepin-1-yl)ethoxy]phenyl]methyl]-2-(4-hydroxyphenyl)-3-methyl-, hydrochloride;1H-Indol-5-ol, 1-[[4-[2-(hexahydro-1H-azepin-1-yl)ethoxy]phenyl]methyl]-2-(4-hydroxyphenyl)-3-methyl-, hydrochloride (1;1H-Indol-5-ol, 1-[[4-[2-(hexahydro-1H-azepin-1-yl)ethoxy]phenyl]methyl]-2-(4-hydroxyphenyl)-3-methyl-, hydrochloride (1:1);1H-Indol-5-ol, 1-[[4-[2-(hexahydro-1H-azepin-1-yl)ethoxy]phenyl]methyl]-2-(4-hydroxyphenyl)-3-methyl-, hydrochloride (1:1) USP/EP/BP
CBNumber:
CB82729659
Molecular Formula:
C30H35ClN2O3
Molecular Weight:
507.0635
MDL Number:
MFCD20926427
MOL File:
198480-56-7.mol
Last updated:2024-11-19 20:33:22

1H-Indol-5-ol, 1-[[4-[2-(hexahydro-1H-azepin-1-yl)ethoxy]phenyl]methyl]-2-(4-hydroxyphenyl)-3-methyl-, hydrochloride (1:1) Properties

storage temp. Store at -20°C
solubility ≥25.35 mg/mL in DMSO
form solid

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS08
Signal word  Danger
Hazard statements  H360
Precautionary statements  P201-P202-P281-P308+P313-P405-P501

1H-Indol-5-ol, 1-[[4-[2-(hexahydro-1H-azepin-1-yl)ethoxy]phenyl]methyl]-2-(4-hydroxyphenyl)-3-methyl-, hydrochloride (1:1) price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
ApexBio Technology B1519 BazedoxifeneHCl 198480-56-7 25mg $558 2021-12-16 Buy
CSNpharm CSN18837 BazedoxifeneHCl 198480-56-7 10mg $158 2021-12-16 Buy
CSNpharm CSN18837 BazedoxifeneHCl 198480-56-7 25mg $245 2021-12-16 Buy
Product number Packaging Price Buy
B1519 25mg $558 Buy
CSN18837 10mg $158 Buy
CSN18837 25mg $245 Buy

1H-Indol-5-ol, 1-[[4-[2-(hexahydro-1H-azepin-1-yl)ethoxy]phenyl]methyl]-2-(4-hydroxyphenyl)-3-methyl-, hydrochloride (1:1) Chemical Properties,Uses,Production

Biological Activity

bazedoxifene hcl is a novel, non-steroidal and indole-based estrogen receptor modulator (serm). the ic50 value of bazedoxifene against erα and erβ is 23 nm and 89 nm, respectively [1,2].the estrogen receptor (er) contains two subtypes, erα and erβ. ers are widely expressed in different tissue types such as kidney, brain, bone, heart, prostate, and endothelial cells. estrogen and the ers have been involved in most cancers such as breast cancer,ovarian cancer,colon cancer,prostate cancer, and endometrial cancer [3].

in vitro

bazedoxifene is a selective serm currently in development for osteoporosis prevention and treatment. bazedoxifene was the third generation serm. in cultured breast cancer (bmcf-7) cells, bazedoxifenedidn’t stimulate erα mediated transcriptional activity and acted as an antagonist to estradiol. similar results were also seen in other cell lines including cho (ovarian), hepg2 (hepatic) or gti-7 (neuronal) with bazedoxifene having no erα agonist activity and acting as an antagonist to estradiol action [2].bazedoxifene didn’t stimulate proliferation of mcf-7 cells but inhibited 17β-estradiol-induced proliferation with an ic50 value of 0.19 nm [4].

in vivo

in an immature rat model, bazedoxifene increased uterine wet weight 35% at a dose of 0.5 mg/kg compared to an 85% increase with raloxifene at the same dose and a 300% increase in uterine weight with ethinyl estradiol at a dose of 10 μg/kg. ovarectomized rats treated with 0.3 mg/d bazedoxifene displayed maintenance of bone mass and bone strength similar to effects seen with 2 μg/d ethinyl estradiol, 3 mg/d raloxifene, or sham operated animals. in an immature rat uterine model, bazedoxifene (0.5 and 5.0 mg/kg) was associated with less increase in uterine wet weight than either ethinyl estradiol (10 μg/kg) or raloxifene (0.5 and 5.0 mg/kg) [4].

References

[1]. miller c p, collini m d, tran b d, et al. design, synthesis, and preclinical characterization of novel, highly selective indole estrogens[j]. journal of medicinal chemistry, 2001, 44(11): 1654-1657.
[2]. biskobing d m. update on bazedoxifene: a novel selective estrogen receptor modulator[j]. clinical interventions in aging, 2007, 2(3): 299.
[3]. harris h a, albert l m, leathurby y, et al. evaluation of an estrogen receptor-β agonist in animal models of human disease[j]. endocrinology, 2003, 144(10): 4241-4249.
[4]. komm b s, kharode y p, bodine p v n, et al. bazedoxifene acetate: a selective estrogen receptor modulator with improved selectivity[j]. endocrinology, 2005, 146(9): 3999-4008.

1H-Indol-5-ol, 1-[[4-[2-(hexahydro-1H-azepin-1-yl)ethoxy]phenyl]methyl]-2-(4-hydroxyphenyl)-3-methyl-, hydrochloride (1:1) Preparation Products And Raw materials

Raw materials

Preparation Products

1H-Indol-5-ol, 1-[[4-[2-(hexahydro-1H-azepin-1-yl)ethoxy]phenyl]methyl]-2-(4-hydroxyphenyl)-3-methyl-, hydrochloride (1:1) Suppliers

Global( 35)Suppliers
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Hubei Jusheng Technology Co.,Ltd. 		18871490254 linda@hubeijusheng.com CHINA 28172 58
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32161 58
Career Henan Chemica Co 		+86-0371-86658258 +8613203830695 laboratory@coreychem.com China 30239 58
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Zhejiang J&C Biological Technology Co.,Limited 		+1-2135480471 +1-2135480471 sales@sarms4muscle.com China 10473 58
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Aladdin Scientific 		+1-+1(833)-552-7181 sales@aladdinsci.com United States 57505 58
Hubei Jusheng Technology Co.,Ltd 027-59599241 18871490274 1400878000@qq.com China 9958 58
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View Lastest Price from 1H-Indol-5-ol, 1-[[4-[2-(hexahydro-1H-azepin-1-yl)ethoxy]phenyl]methyl]-2-(4-hydroxyphenyl)-3-methyl-, hydrochloride (1:1) manufacturers

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Bazedoxifene hydrochloride pictures 2024-11-19 Bazedoxifene hydrochloride
198480-56-7
 US $55.00-252.00 / mg 98.74% 10g TargetMol Chemicals Inc.

198480-56-7(1H-Indol-5-ol, 1-[[4-[2-(hexahydro-1H-azepin-1-yl)ethoxy]phenyl]methyl]-2-(4-hydroxyphenyl)-3-methyl-, hydrochloride (1:1))Related Search:

1H-Indol-5-ol, 1-[[4-[2-(hexahydro-1H-azepin-1-yl)ethoxy]phenyl]methyl]-2-(4-hydroxyphenyl)-3-methyl-, hydrochloride (1:1) Bazedoxifene HCl Bazedoxifene hydrochloride CS-1416 1H-Indol-5-ol, 1-[[4-[2-(hexahydro-1H-azepin-1-yl)ethoxy]phenyl]methyl]-2-(4-hydroxyphenyl)-3-methyl-, hydrochloride (1 1H-Indol-5-ol, 1-[[4-[2-(hexahydro-1H-azepin-1-yl)ethoxy]phenyl]methyl]-2-(4-hydroxyphenyl)-3-methyl-, hydrochloride 1H-Indol-5-ol, 1-[[4-[2-(hexahydro-1H-azepin-1-yl)ethoxy]phenyl]methyl]-2-(4-hydroxyphenyl)-3-methyl-, hydrochloride (1:1) USP/EP/BP Bazedoxifene acetate HCL Bazedoxifene (WAY-140424) HCl 198480-56-7 C30H34N2O3HCl Inhibitors