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ChemicalBook >> CAS DataBase List >>Pramipexole Impurity 16

Pramipexole Impurity 16

CAS No.
104632-27-1
Chemical Name:
Pramipexole Impurity 16
Synonyms
RPPX;Kns 760704;Snd 919cl2x;Dexpramipexole HCl;Dexpramipexole 2HCl;Pramipexole R-Isomer;PraMipexole IMpurity D;Pramipexole BP Impurity D;Pramipexole impurity D CRS;KNS-760704 dihydrochloride
CBNumber:
CB82449027
Molecular Formula:
C10H18ClN3S
Molecular Weight:
247.79
MDL Number:
MFCD09031317
MOL File:
104632-27-1.mol
MSDS File:
SDS
Last updated:2025-05-15 16:23:50

Pramipexole Impurity 16 Properties

storage temp. -20°C
solubility H2O: >15mg/mL
form powder
color white to beige
optical activity [α]/D 60 to 70°, c = 1 in methanol
FDA UNII I9038PKO43
UNSPSC Code 41116107
NACRES NA.24

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302
Precautionary statements  P301+P312+P330
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26
WGK Germany  3
HS Code  2934200000
NFPA 704
0
2 0

Pramipexole Impurity 16 price More Price(30)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 1553815 Pramipexole Related Compound D United States Pharmacopeia (USP) Reference Standard 104632-27-1 25mg $1210 2024-03-01 Buy
Sigma-Aldrich PHR1824 Pramipexole Related Compound D Pharmaceutical Secondary Standard; Certified Reference Material 104632-27-1 50mg $675 2022-05-15 Buy
Cayman Chemical 18234 (R)-Pramipexole (hydrochloride) ≥95% 104632-27-1 5mg $65 2024-03-01 Buy
Cayman Chemical 18234 (R)-Pramipexole (hydrochloride) ≥95% 104632-27-1 10mg $121 2024-03-01 Buy
Sigma-Aldrich SML0392 Dexpramipexole dihydrochloride ≥98% (HPLC) 104632-27-1 10mg $148 2022-05-15 Buy
Product number Packaging Price Buy
1553815 25mg $1210 Buy
PHR1824 50mg $675 Buy
18234 5mg $65 Buy
18234 10mg $121 Buy
SML0392 10mg $148 Buy

Pramipexole Impurity 16 Chemical Properties,Uses,Production

Description

Pramipexole (Item No. 11981) is an agonist of dopamine receptors that has applications in Parkinson’s disease and other disorders. Pramipexole is usually available as a mixture of enantiomers, with the majority of the dopamine receptor-dependent activity resulting from the (S) form. (R)-Pramipexole is an enantiomer of pramipexole that is ~100-fold less active than the (S) form as a dopamine receptor agonist. For this reason, it can be used as a negative control for the (S) form in the study of dopamine receptors. Both isoforms are antioxidants that target mitochondria to prevent apoptosis. This cytoprotective effect of (R)-pramipexole, without dopaminergic side effects, suggests utility in amyotrophic lateral sclerosis.

Uses

(R)-Pramipexole Dihydrochloride (Pramipexole EP Impurity D; Pramipexole BP Impurity D; Pramipexole USP Related Compound D) is the opposite enantiomer of Pramipexole (P700755), a dopamine-D2-receptor agonist. Dexpramipexole is a low-molecular-weight, water-soluble, orally bioavailable, renally excreted compound with linear pharmacokinetics.

Uses

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements. Pramipexole may be used as a secondary pharma standard for the determination of the analyte in pharmaceutical formulations using reversed-phase high-performance liquid chromatography and ultraviolet spectrophotometry technique.

General Description

Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. Pramipexole Related Compound D is a pharmaceutical impurity of pramipexole. Pramipexole is a non-ergot dopamine receptor agonist, widely used in the treatment of Parkinson′s disease.

Biochem/physiol Actions

R-(+)-Pramipexole is a neuroprotective agent; weak non-ergoline dopamine agonist. R-(+)-Pramipexole has been found to have neuroprotective effects and is being investigated for treatment of ALS. It reduces mitochondrial reactive oxygen species (ROS) production, inhibits the activation of apoptotic pathways, and increase cell survival in response to a variety of neurotoxins and β-amyloid neurotoxicity. Compared to the S-(-) isomer, R-(+)-Pramipexole has much lower dopamine agonist activity.

Pramipexole Impurity 16 Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 91)Suppliers
Supplier Tel Email Country ProdList Advantage
Hubei Jusheng Technology Co.,Ltd. 		18871490254 linda@hubeijusheng.com CHINA 28172 58
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32275 58
HANGZHOU CLAP TECHNOLOGY CO.,LTD 		86-571-88216897,88216896 13588875226 sales@hzclap.com CHINA 6312 58
Labnetwork lnc. 		+86-27-50766799 +8618062016861 contact@labnetwork.com China 19987 58
sgtlifesciences pvt ltd 		+8617013299288 dj@sgtlifesciences.com China 12373 58
InvivoChem 		+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6391 58
Nanjing Doge Biomedical Technology Co., Ltd 		+86-25-58227606 +86-15305155328 sales@dogechemical.com China 4128 58
TargetMol Chemicals Inc. 		support@targetmol.com United States 38664 58
Wuhan Topule Biopharmaceutical Co., Ltd 		+8618327326525 masar@topule.com China 8467 58
Aladdin Scientific 		tp@aladdinsci.com United States 52924 58

View Lastest Price from Pramipexole Impurity 16 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Dexpramipexole dihydrochloride pictures 2025-05-15 Dexpramipexole dihydrochloride
104632-27-1
 US $44.00-155.00 / mg 99.75% 10g TargetMol Chemicals Inc.
Dexpramipexole dihydrochloride pictures 2025-05-15 Dexpramipexole dihydrochloride
104632-27-1
 US $44.00-155.00 / mg 99.75% 10g TargetMol Chemicals Inc.
Pramipexole Impurity D pictures 2024-04-10 Pramipexole Impurity D
US $0.00-0.00 / mg 10mg 90%+ 10g Guangzhou PI PI BIOTECH INC
2,6-Benzothiazolediamine, 4,5,6,7-tetrahydro-N6-propyl-, dihydrochloride, (R)- Kns 760704 Snd 919cl2x DexpraMipexole (dihydrochloride) PraMipexole IMpurity D (R)-2-Amino-4,5,6,7-tetrahydro-6-(propylamino)benzothiazole dihydrochloride // (R)-Pramipexole dihydrochloride (R)-4,5,6,7-Tetrahydro-6-(propylamino)-benzothiazole-2-amine dihydrochloride RPPX Pramipexole Dihydrochloride Hydrate Impurity (R)-Pramipexole (hydrochloride) Pramipexole Dihydrochloride Hydrate IMP Pramipexole dihydrochloride impurity IV (R)-PRAMIPEXOLE DIHYDROCHLORIDE; KNS 760704; SND 919CL2X Pramipexole R-Isomer Pramipexole EP Impurity D DiHCl (6R)-6-N-propyl-4,5,6,7-tetrahydro-1,3-benzothiazole-2,6-diamine,dihydrochloride Dexpramipexole dihydrochloride ((R)-Pramipexole Pramipexole impurity D CRS KNS-760704 dihydrochloride (R)-N6-propyl-4,5,6,7-tetrahydrobenzo[d]thiazole-2,6-diamine dihydrochloride Dexpramipexole HCl Pramipexole EP Impurity D ((R)-Pramipexole diHCl) Pramipexole Related Compound D ((R)-2-Amino-4,5,6,7-tetrahydro-6-(propylamino)benzothiazole dihydro (1553815) Dexpramipexole dihydrochloride ((R)-Pramipexole dihydrochloride Dopamine Receptor,inhibit,Inhibitor,KNS-760704,Dexpramipexole,Dexpramipexole dihydrochloride,(R)-Pramipexole,KNS760704,KNS 760704 Pramipexole Impurity 4 Dihydrochloride（Pramipexole EP Impurity D Dihydrochloride） Dexpramipexole 2HCl Glycerol Impurity 41((R)-3-chloropropane-1,2-diol) Pramipexole BP Impurity D Pramipexole EP Impurity D HCl Pramipexole Impurity D (R-Isomer) Dexpramipexole dihydrochloride, 10 mM in DMSO 104632-27-1 28425