RLY-4008 HCl
- CAS No.
- 2688040-45-9
- Chemical Name:
- RLY-4008 HCl
- Synonyms
- RLY-4008 HCl;FGFR2-IN-3 hydrochloride;lirafugratinib (RLY4008);Lirafugratinib Hydrochloride;N-(4-(4-Amino-5-(3-fluoro-4-((4-methylpyrimidin-2-yl)oxy)phenyl)-7-methyl-7H-pyrrolo[2,3-d]pyrimidin-6-yl)phenyl)methacrylamide hydrochloride
- CBNumber:
- CB812106578
- Molecular Formula:
- C28H25ClFN7O2
- Molecular Weight:
- 546
- MDL Number:
- MOL File:
- 2688040-45-9.mol
| form | Solid |
|---|---|
| color | Light brown to brown |
| FDA UNII | 4P76F4XM3B |
RLY-4008 HCl Chemical Properties,Uses,Production
Uses
Lirafugratinib (RLY-4008) hydrochloride is an orally active, irreversible and highly selective FGFR2 inhibitor with an IC50 of 3 nM. Lirafugratinib hydrochloride covalently binds to Cys491. Lirafugratinib hydrochloride targets FGFR2 primary alterations and resistance mutations and induces tumor regression while sparing other FGFRs[1].
in vivo
Lirafugratinib (RLY-4008; 1-30 mg/kg; orally, twice daily; 15-30 days) hydrochloride demonstrates antitumor activity in FGFR2-altered cancer xenograft models[1].
| Animal Model: | Female BALB/c nude mice with SNU-16 and AN3CA xenografts; female NOD SCID mice with CC13-7 and ICC13-7-FGFR2V564F xenografts[1] |
| Dosage: | 1, 3, 10, 30 mg/kg |
| Administration: | Orally; twice daily; for 15-30 days |
| Result: | Exhibited dose-dependent antitumor activity and induced tumor regression in all models. |
IC 50
FGFR2: 3 nM (IC50)
References
[1] Vivek Subbiah, et al. RLY-4008, the First Highly Selective FGFR2 Inhibitor with Activity across FGFR2 Alterations and Resistance Mutations. Cancer Discov. 2023 Sep 6;13(9):2012-2031. DOI:10.1158/2159-8290.CD-23-0475
RLY-4008 HCl Preparation Products And Raw materials
Raw materials
Preparation Products
RLY-4008 HCl Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Aladdin Scientific | tp@aladdinsci.com | United States | 52924 | 58 | |
| TargetMol Chemicals Inc. | +8613564774135 | zijue.cai@tsbiochem.com | United States | 19905 | 58 |
| WUHAN SUN-SHINE BIO-TECHNOLOGY Co., Ltd. | 17702719238 17702719238 | sales@sun-shinechem.com | China | 1040 | 64 |
| ShangHai Caerulum Pharma Discovery Co., Ltd. | 18149758185 18149758185 | sales-cpd@caerulumpharma.com | China | 3467 | 58 |
| Shanghai XingMo Biotechnology Co., Ltd. | +86 13524779951; 13524779951 | 2075692521@qq.com | China | 310 | 55 |
| Bide Pharmatech Ltd. | 400-1647117 13681763483 | product02@bidepharm.com | China | 62321 | 58 |
| TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 24875 | 58 |
| Nantong QuanYi Biotechnology Co., Ltd | 0513-66337626 18051384581 | sales@chemhifuture.com | China | 5519 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 11973 | 58 |
| Jiangsu Aikon Biopharmaceutical R&D Co.,Ltd. | 025-66061636 18013972705 | qqyang@aikonchem.com | China | 10152 | 58 |
View Lastest Price from RLY-4008 HCl manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-04-29 | FGFR2-IN-3 hydrochloride
2688040-45-9
|
US $766.00-1740.00 / mg | 10g | TargetMol Chemicals Inc. |
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- FGFR2-IN-3 hydrochloride
2688040-45-9
- US $766.00-1740.00 / mg
- TargetMol Chemicals Inc.