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ChemicalBook >> CAS DataBase List >>2,4-Imidazolidinedione, 3-cyclopropyl-1-[[4-[6-[(1,1-dioxido-4-thiomorpholinyl)methyl]-5-fluoro-2-pyridinyl]phenyl]methyl]-, hydrochloride (1:1)

2,4-Imidazolidinedione, 3-cyclopropyl-1-[[4-[6-[(1,1-dioxido-4-thiomorpholinyl)methyl]-5-fluoro-2-pyridinyl]phenyl]methyl]-, hydrochloride (1:1)

CAS No.
2250025-91-1
Chemical Name:
2,4-Imidazolidinedione, 3-cyclopropyl-1-[[4-[6-[(1,1-dioxido-4-thiomorpholinyl)methyl]-5-fluoro-2-pyridinyl]phenyl]methyl]-, hydrochloride (1:1)
Synonyms
2,4-Imidazolidinedione, 3-cyclopropyl-1-[[4-[6-[(1,1-dioxido-4-thiomorpholinyl)methyl]-5-fluoro-2-pyridinyl]phenyl]methyl]-, hydrochloride (1:1)
CBNumber:
CB811028615
Molecular Formula:
C23H26ClFN4O4S
Molecular Weight:
508.99
MDL Number:
MOL File:
2250025-91-1.mol
Last updated:2025-04-28 21:36:36

2,4-Imidazolidinedione, 3-cyclopropyl-1-[[4-[6-[(1,1-dioxido-4-thiomorpholinyl)methyl]-5-fluoro-2-pyridinyl]phenyl]methyl]-, hydrochloride (1:1) Properties

solubility DMSO:50.9(Max Conc. mg/mL);100.0(Max Conc. mM)

2,4-Imidazolidinedione, 3-cyclopropyl-1-[[4-[6-[(1,1-dioxido-4-thiomorpholinyl)methyl]-5-fluoro-2-pyridinyl]phenyl]methyl]-, hydrochloride (1:1) Chemical Properties,Uses,Production

Description

LEI 101 hydrochloride is potent and selective CB2 partial agonist.

in vitro

LEI-101 behaved as a partial agonist at CB2 receptors using β-arrestin and GTPγS assays and was ~100-fold selective in CB2 /CB1 receptor-binding assays._x000D_ _x000D_ Reference: Br J Pharmacol. 2016 Feb;173(3):446-58. https://pubmed.ncbi.nlm.nih.gov/21923175/

in vivo

Systematic modification of physicochemical properties, such as lipophilicity and basicity, was used to optimize the pharmacokinetic profile and hERG affinity of this novel class of cannabinoid CB2 receptor agonists. This led to the identification of 44 (LEI 101) as a potent, selective, and orally bioavailable cannabinoid CB2 receptor agonist (hCB2 pEC(50) = 8.0; hERG pK(i) < 4; F(po) = 100%), which was active in a rat spinal nerve ligation model of neuropathic pain._x000D_ _x000D_ Reference: J Med Chem. 2011 Oct 27;54(20):7350-62. https://pubmed.ncbi.nlm.nih.gov/21923175/

target

LEI-101 is a potent, selective, and orally bioavailable cannabinoid CB2 receptor agonist, with a pEC50 of 8 for hCB2, and a pKi of less than 4 for hERG.

storage

Store at -20°C

2,4-Imidazolidinedione, 3-cyclopropyl-1-[[4-[6-[(1,1-dioxido-4-thiomorpholinyl)methyl]-5-fluoro-2-pyridinyl]phenyl]methyl]-, hydrochloride (1:1) Preparation Products And Raw materials

Raw materials

Preparation Products

2,4-Imidazolidinedione, 3-cyclopropyl-1-[[4-[6-[(1,1-dioxido-4-thiomorpholinyl)methyl]-5-fluoro-2-pyridinyl]phenyl]methyl]-, hydrochloride (1:1) Suppliers

Global( 6)Suppliers
Supplier Tel Email Country ProdList Advantage
Aladdin Scientific 		tp@aladdinsci.com United States 52924 58
TargetMol Chemicals Inc. 		+8613564774135 zijue.cai@tsbiochem.com United States 19897 58
Hefei fuya biotechnology co. LTD 18096409024 sales02@foreversyn.com China 1951 58
TargetMol Chemicals Inc. 4008200310 marketing@tsbiochem.com China 24739 58
Nantong QuanYi Biotechnology Co., Ltd 0513-66337626 18051384581 sales@chemhifuture.com China 5237 58
R&D Systems, Inc 18003437475 18003437475 rdname@qq.com China 35960 58

View Lastest Price from 2,4-Imidazolidinedione, 3-cyclopropyl-1-[[4-[6-[(1,1-dioxido-4-thiomorpholinyl)methyl]-5-fluoro-2-pyridinyl]phenyl]methyl]-, hydrochloride (1:1) manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
LEI 101 hydrochloride pictures 2025-04-27 LEI 101 hydrochloride
2250025-91-1
 US $1520.00-2500.00 / mg 10g TargetMol Chemicals Inc.
2,4-Imidazolidinedione, 3-cyclopropyl-1-[[4-[6-[(1,1-dioxido-4-thiomorpholinyl)methyl]-5-fluoro-2-pyridinyl]phenyl]methyl]-, hydrochloride (1:1) 2250025-91-1