Otelixizumab
- CAS No.
- 881191-44-2
- Chemical Name:
- Otelixizumab
- Synonyms
- Otelixizumab;Otelixizumab (anti-CD3);Research Grade Otelixizumab;Research Grade Otelixizumab(DHC27702)
- CBNumber:
- CB78080780
- Molecular Formula:
- Molecular Weight:
- 0
- MDL Number:
- MOL File:
- Mol file
| form | Liquid |
|---|---|
| color | Colorless to light yellow |
| FDA UNII | I5HF2X04PB |
Otelixizumab Chemical Properties,Uses,Production
Uses
Otelixizumab (ChAglyCD3) is an anti-human CD3 monoclonal antibody and can be used for the research of type 1 diabetes[1].
in vivo
Otelixizumab (ChAglyCD3) (100 μg/mouse; i.v.; once) results in durable disease remission dependent on transferable T cell–mediated tolerance in diabetic transgenic mice[1].
| Animal Model: | BALB/c-huCD3e mice carrying the human CD3e chain[1] |
| Dosage: | 100 μg/mouse |
| Administration: | Intravenous injection, once |
| Result: | Induced secretion of lower amounts of IL-6. Exhibited up-regulation of regulatory T cells. |
References
[1] Kuhn C, et al. Human CD3 transgenic mice: preclinical testing of antibodies promoting immune tolerance. Sci Transl Med. 2011 Feb 2;3(68):68ra10. DOI:10.1126/scitranslmed.3001830
[2] Guglielmi C, et al. Efficacy and safety of otelixizumab use in new-onset type 1 diabetes mellitus. Expert Opin Biol Ther. 2016 Jun;16(6):841-6. DOI:10.1080/14712598.2016.1180363
Otelixizumab Preparation Products And Raw materials
Raw materials
Preparation Products
Otelixizumab Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Aladdin Scientific | tp@aladdinsci.com | United States | 57505 | 58 | |
| Shanghai YuanYe Biotechnology Co., Ltd. | 021-61312847; 18021002903 | 3008007409@qq.com | China | 71826 | 60 |
| ShangHai Biochempartner Co.,Ltd | 17754423994 17754423994 | 2853530910@QQ.com | China | 7988 | 62 |
| Guangzhou Hongyuan Chemical Co.,Ltd | 15817493340 | 981810490@qq.com | China | 1566 | 58 |
| Wuhan Chemstan Biotechnology Co., Ltd. | 027-65317797 15926423062 | 422450190@qq.com | China | 10308 | 58 |
| TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 24890 | 58 |
| Biolab Reagents | 18108604356 18108604356 | info@biolabreagent.com | China | 9868 | 58 |
| Wuhan Jingkangen Biomedical Technology Co., Ltd | 13720134139 086-15871494362 13720134139 | orders@jknbiochem.com | China | 6184 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 11973 | 58 |
| Shanghai Aladdin Biochemical Technology Co.,Ltd. | 400-6206333 13167063860 | anhua.mao@aladdin-e.com | China | 48458 | 58 |