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ChemicalBook >> CAS DataBase List >>QM31

QM31

CAS No.
937735-00-7
Chemical Name:
QM31
Synonyms
QM31;SVT016426;QM31,QM-31;1H-1,4-Diazepine-5-carboxamide, N-(2-amino-2-oxoethyl)-N,1-bis[2-(2,4-dichlorophenyl)ethyl]-4-(3,3-diphenylpropyl)hexahydro-3,7-dioxo-
CBNumber:
CB75867573
Molecular Formula:
C39H38Cl4N4O4
Molecular Weight:
768.56
MDL Number:
MFCD34469366
MOL File:
937735-00-7.mol
Last updated:2025-04-18 09:52:43

QM31 Properties

Boiling point 960.8±65.0 °C(Predicted)
Density 1.340±0.06 g/cm3(Predicted)
storage temp. Store at -20°C
pka 15.47±0.40(Predicted)
form Solid
color White to off-white

QM31 Chemical Properties,Uses,Production

Uses

QM31 (SVT016426), a cytoprotective agent, is a selective inhibitor of Apaf-1. QM31 inhibits the formation of the apoptosome (IC50=7.9μM), the caspase activation complex composed by Apaf-1, cytochrome c, dATP and caspase-9. QM31 exerts mitochondrioprotective functions and interferes with the intra-S-phase DNA damage checkpoint[1][2].

References

[1] Mondragón L, et al. A chemical inhibitor of Apaf-1 exerts mitochondrioprotective functions and interferes with the intra-S-phase DNA damage checkpoint. Apoptosis. 2009 Feb;14(2):182-90. DOI:10.1007/s10495-008-0310-x
[2] Orzáez M, et al. Apaf-1 inhibitors protect from unwanted cell death in in vivo models of kidney ischemia and chemotherapy induced ototoxicity. PLoS One. 2014 Oct 20;9(10):e110979. DOI:10.1371/journal.pone.0110979
[3] Gortat A, et al. Apaf1 inhibition promotes cell recovery from apoptosis. Protein Cell. 2015 Nov;6(11):833-43. DOI:10.1007/s13238-015-0200-2

QM31 Preparation Products And Raw materials

Raw materials

Preparation Products

QM31 Suppliers

Global( 7)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32275 58
TargetMol Chemicals Inc. 		support@targetmol.com United States 38664 58
TargetMol Chemicals Inc. 		+8613564774135 zijue.cai@tsbiochem.com United States 19905 58
RD International Technology Co., Limited 18024082417 market@ubiochem.com China 9835 58
TargetMol Chemicals Inc. 15002134094 marketing@targetmol.cn China 20020 58
Biosynth Biological Technology (Suzhou) Co Ltd 51288865780 sales@biosynth.com China 233051 58
Nanjing Shizhou Biology Technology Co.,Ltd 025-85560043 15850508050 cindy.huang@synzest.com China 12000 58

View Lastest Price from QM31 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
QM31 pictures 2024-10-28 QM31
937735-00-7
 US $1520.00-1980.00 / mg 10g TargetMol Chemicals Inc.
  • QM31 pictures
  • QM31
    937735-00-7
  • US $1520.00-1980.00 / mg
  • TargetMol Chemicals Inc.
QM31 SVT016426 1H-1,4-Diazepine-5-carboxamide, N-(2-amino-2-oxoethyl)-N,1-bis[2-(2,4-dichlorophenyl)ethyl]-4-(3,3-diphenylpropyl)hexahydro-3,7-dioxo- QM31,QM-31 937735-00-7 C39H38Cl4N4O4