ChemicalBook >> CAS DataBase List >>LSZ-102
LSZ-102
- CAS No.
- 2135600-76-7
- Chemical Name:
- LSZ-102
- Synonyms
- LSZ-102;CS-2791;LSZ102;LSZ-102;LSZ 102;LSZ-102, 10 mM in DMSO;2-Propenoic acid, 3-[4-[[2-[2-(1,1-difluoroethyl)-4-fluorophenyl]-6-hydroxybenzo[b]thien-3-yl]oxy]phenyl]-, (2E)-
- CBNumber:
- CB74629486
- Molecular Formula:
- C25H17F3O4S
- Molecular Weight:
- 470.46
- MDL Number:
- MFCD31657401
- MOL File:
- 2135600-76-7.mol
Last updated:2025-04-17 18:22:24
| Boiling point | 643.5±55.0 °C(Predicted) |
|---|---|
| Density | 1.418±0.06 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | Soluble in DMSO |
| form | Solid |
| pka | 4.49±0.10(Predicted) |
| color | White to light yellow |
| FDA UNII | 0Y175XGX4P |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
LSZ-102 Chemical Properties,Uses,Production
Uses
is a potent, orally bioavailable selective estrogen receptor degrader currently being studied for the treatment of ERα positive breast cancer.
in vivo
Treatment of the mice with LSZ-102 once daily at 20 mg/kg results in significant tumor growth inhibition as compare to the control group treated with vehicle alone, resulting in tumor stasis (mean change in tumor volume of LSZ-102 vs control=%ΔT/ΔC of 2.4% on day 48, p<0.05). Dosing of 3 mg/kg solution of LSZ-102 in male Sprague-Dawley rats results in 33% bioavailability and a dose-normalized exposure of 620 nM h[1].
LSZ-102 Preparation Products And Raw materials
Raw materials
Preparation Products
LSZ-102 Suppliers
Global( 45)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| SHANGHAI T&W PHARMACEUTICAL CO., LTD. | +86-021-61551413 +8618813727289 | contact@trustwe.com | China | 5738 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32239 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
| Nantong HI-FUTURE Biology Co., Ltd. | +undefined18051384581 | sales@chemhifuture.com | China | 3135 | 58 |
| Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | masar@topule.com | China | 8467 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 52924 | 58 | |
| Suzhou ARTK Medchem Co., Ltd. | +86-512-68323658 +86-18168183658 | sales1@artkmedchem.com | China | 39003 | 58 |
| ShangHai Caerulum Pharma Discovery Co., Ltd. | 18149758185 18149758185 | sales-cpd@caerulumpharma.com | China | 3466 | 58 |
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 | China | 4613 | 55 |
LSZ-102
LSZ102;LSZ-102;LSZ 102
CS-2791
2-Propenoic acid, 3-[4-[[2-[2-(1,1-difluoroethyl)-4-fluorophenyl]-6-hydroxybenzo[b]thien-3-yl]oxy]phenyl]-, (2E)-
LSZ-102, 10 mM in DMSO
2135600-76-7
C25H17F3O4S
APIs