Cevimeline Hydrochloride Salt
- CAS No.
- 107220-28-0
- Chemical Name:
- Cevimeline Hydrochloride Salt
- Synonyms
- SNK 508;Fks 508;Snd 5008;Saligren;CeviMelin;rac-Cevimeline HCl;AF-102B hydrochloride;SNI-2011 hydrochloride;Cevimelin Hydrochloride;CEVIMELINE, HYDROCHLORIDE SALT
- CBNumber:
- CB72130375
- Molecular Formula:
- C10H18ClNOS
- Molecular Weight:
- 235.77402
- MDL Number:
- MFCD01961045
- MOL File:
- 107220-28-0.mol
| Melting point | 195-197?C |
|---|---|
| storage temp. | Inert atmosphere,Store in freezer, under -20°C |
| solubility | Water:50.0(Max Conc. mg/mL);212.07(Max Conc. mM) |
| form | A crystalline solid |
| color | White to off-white |
| Stability | Hygroscopic |
| FDA UNII | H0913EZ23C |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H301 | |||||||||
| Precautionary statements | P261-P280-P301+P312-P302+P352-P305+P351+P338 | |||||||||
| Toxicity | mouse,LD50,intravenous,33mg/kg (33mg/kg),United States Patent Document. Vol. #4855290, | |||||||||
| NFPA 704 |
|
Cevimeline Hydrochloride Salt price More Price(26)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 17802 | Cevimeline (hydrochloride) ≥98% | 107220-28-0 | 1mg | $37 | 2024-03-01 | Buy |
| Cayman Chemical | 17802 | Cevimeline (hydrochloride) ≥98% | 107220-28-0 | 5mg | $98 | 2024-03-01 | Buy |
| Cayman Chemical | 17802 | Cevimeline (hydrochloride) ≥98% | 107220-28-0 | 10mg | $161 | 2024-03-01 | Buy |
| Usbiological | C3160 | Cevimeline, Hydrochloride Salt | 107220-28-0 | 5mg | $403 | 2021-12-16 | Buy |
| TRC | C283500 | rac,cis-CevimelineHydrochlorideSalt | 107220-28-0 | 10mg | $145 | 2021-12-16 | Buy |
Cevimeline Hydrochloride Salt Chemical Properties,Uses,Production
Chemical Properties
Off-White Solid
Uses
A novel muscarinic M1 and M3 receptor agonist. Sialagogue.
Biological Activity
Selective M 1 receptor agonist. Induces atropine-sensitive contractions of isolated guinea pig ilea and trachea preparations (EC 50 values are 3.5 and 3 μ M respectively). Reverses AF64A-induced cognitive impairments in vivo .
in vivo
Cevimeline (0.008-0.016 mg/kg; intraperitoneal injection; male Wistar rats) treatment shows slowly increasing and lasting salivation, and increased blood flow increment in the parotid gland and pressor response. Cevimeline inhibits angiotensin II-induced water intake and neuronal activity in the subfornical organ at 0.016 mg/kg[1].
| Animal Model: | Male Wistar rats (8-week-old) injected with angiotensin-II[1] |
| Dosage: | 0.008 mg/kg, 0.016 mg/kg |
| Administration: | Intraperitoneal injection |
| Result: | Showed slowly increasing and lasting salivation, and increased blood flow increment in the parotid gland and pressor response. |
IC 50
mAChR1; mAChR3
storage
-20°C
Cevimeline Hydrochloride Salt Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| HangZhou RunYan Pharma Technology Co.,LTD. | +8618882027439 | sales2@runyanpharma.com | China | 302 | 58 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28172 | 58 |
| Standardpharm Co. Ltd. | 86-714-3992388 | overseasales1@yongstandards.com | United States | 14332 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32276 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6312 | 58 |
| TargetMol Chemicals Inc. | support@targetmol.com | United States | 38664 | 58 | |
| GIHI CHEMICALS CO.,LIMITED | +8618058761490 | info@gihichemicals.com | China | 49980 | 58 |
| Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | masar@topule.com | China | 8467 | 58 |
| Zibo Hangyu Biotechnology Development Co., Ltd | +86-0533-2185556 +8615965530500 | nickzhang@hangyubiotech.com | China | 10968 | 58 |
| LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43340 | 58 |
View Lastest Price from Cevimeline Hydrochloride Salt manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-05-08 | Cevimeline HCl; Cevimeline;AF102B
107220-28-0
|
US $0.00 / kg | 1kg | 99.0%min. HPLC | 1000kg | HangZhou RunYan Pharma Technology Co.,LTD. | |
 |
2024-10-28 | Cevimeline hydrochloride
107220-28-0
|
US $59.00 / mg | 10g | TargetMol Chemicals Inc. |
-
- Cevimeline HCl; Cevimeline;AF102B
107220-28-0
- US $0.00 / kg
- 99.0%min. HPLC
- HangZhou RunYan Pharma Technology Co.,LTD.
-
- Cevimeline hydrochloride
107220-28-0
- US $59.00 / mg
- TargetMol Chemicals Inc.