ChemicalBook >> CAS DataBase List >>Trifluoroacetic anhydride
Trifluoroacetic anhydride
- CAS No.
- 407-25-0
- Chemical Name:
- Trifluoroacetic anhydride
- Synonyms
- TFAA;trifluoroacetic;2,2,2-Trifluoroacetic anhydride;TRIFLUOROACETIC ACID ANHYDRIDE;TRIFLUORACETIC ANHYDRIDE;Trifluoroacetic anhy;TIFLUOROACETIC ANHYDRIDE;trimethylamine (TMA);uoroacetic anhydride;TRIFLUOROACETO ANHYDRIDE
- CBNumber:
- CB6853606
- Molecular Formula:
- C4F6O3
- Molecular Weight:
- 210.03
- MDL Number:
- MFCD00000416
- MOL File:
- 407-25-0.mol
- MSDS File:
- SDS
Last updated:2024-12-18 14:15:30
| Melting point | -65 °C (lit.) |
|---|---|
| Boiling point | 39.5-40 °C (lit.) |
| Density | 1.511 g/mL at 20 °C (lit.) |
| vapor pressure | 6.28 psi ( 20 °C) |
| refractive index |
n |
| Flash point | -26 °C |
| storage temp. | 2-8°C |
| solubility | Miscible with benzene, dichloromethane, diethyl ether, dimethylformamide, terahydrofuran and acetonitrile. |
| form | Liquid |
| pka | 0.43[at 20 ℃] |
| Specific Gravity | 1.487 |
| color | Clear |
| Water Solubility | Hydrolysis |
| Sensitive | Moisture Sensitive |
| BRN | 746197 |
| Stability | Stable, but moisture sensitive. Reacts with water to liberate hydrogen (flammable!). Incompatible with water, strong oxidizing agents. |
| LogP | 0.79 at 25℃ |
| CAS DataBase Reference | 407-25-0(CAS DataBase Reference) |
| FDA UNII | 5ENA87IZHT |
| NIST Chemistry Reference | Acetic acid, trifluoro-, anhydride(407-25-0) |
| EPA Substance Registry System | Acetic acid, trifluoro-, anhydride (407-25-0) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS05,GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H314-H332-H412 | |||||||||
| Precautionary statements | P273-P280-P301+P330+P331-P303+P361+P353-P304+P340+P312-P305+P351+P338+P310 | |||||||||
| Hazard Codes | C,T | |||||||||
| Risk Statements | 14-20-35-52/53-34-23/24/25 | |||||||||
| Safety Statements | 26-36/37/39-43-45-61-9-8-28A-27 | |||||||||
| RIDADR | UN 3265 8/PG 1 | |||||||||
| WGK Germany | 2 | |||||||||
| RTECS | AJ9800000 | |||||||||
| F | 3-10 | |||||||||
| Hazard Note | Corrosive/Moisture Sensitive | |||||||||
| TSCA | T | |||||||||
| HazardClass | 8 | |||||||||
| PackingGroup | I | |||||||||
| HS Code | 29159080 | |||||||||
| Toxicity | skn-rbt 500 mg/24H SEV 28ZPAK -,91,72 | |||||||||
| NFPA 704 |
|
Trifluoroacetic anhydride price More Price(56)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 8.08261 | Trifluoroacetic anhydride for synthesis | 407-25-0 | 25mL | $43.7 | 2024-03-01 | Buy |
| Sigma-Aldrich | 8.08261 | Trifluoroacetic anhydride for synthesis | 407-25-0 | 100mL | $114 | 2024-03-01 | Buy |
| Sigma-Aldrich | 106232 | Trifluoroacetic anhydride ReagentPlus , ≥99% | 407-25-0 | 10x1g | $212 | 2024-03-01 | Buy |
| Sigma-Aldrich | 8.08261 | Trifluoroacetic anhydride for synthesis | 407-25-0 | 500mL | $456 | 2024-03-01 | Buy |
| Sigma-Aldrich | 106232 | Trifluoroacetic anhydride ReagentPlus , ≥99% | 407-25-0 | 3kg | $1460 | 2024-03-01 | Buy |
Trifluoroacetic anhydride Chemical Properties,Uses,Production
Description
Trifluoroacetic acid anhydride (TFAA), a perfluoroacylated acylation reagent, forms stable, volatile derivatives with alcohols, amines, and phenols.
Chemical Properties
Clear, colorless liquid
Uses
Trifluoroacetic anhydride is used for the introduction of trifluoroacetyl group in organic synthesis. It is involved in the preparation of N- and O-trifluoroacetyl derivatives of a wide range of biologically active compounds for gas chromatography analysis. It plays an important role as desiccant for trifluoroacetic acid. It is also used in the oxidation of aldehydes to acids, esters, amides as well as in the protection of alcohols and amines. In addition, it is used as analytical reagents, solvents and dehydration condensing agent. It serves as an intermediate of fluorine fine chemicals, pharmaceuticals and agrochemicals.
Uses
Used as analytical reagents, solvents, catalysts, dehydration condensing agent, protection agent of trifluoroacetylation of carboxyl and amino; used as Intermediate of fluorine fine chemicals, pharmaceutical, agrochemical.
Preparation
Trifluoroacetic anhydride is prepared by reaction of trifluoroacetyl chloride with an alkali metal or alkaline-earth metal salt of trifluoroacetic acid at approximately 50° C.
Safety Profile
A severe skin and eye irritant.Explosive reaction with dimethyl sulfoxide; nitric acid +1,3,5-triazine (at 36°C); nitric acid + 1,3,5-triacetylhexahydro-1,3,5-triazine (at 30°C). Incompatiblewith lithium tetrahydroaluminate. When heated todecomposit
Purification Methods
Purification by distilling over KMnO4, as for the acid above, is EXTREMELY DANGEROUS due to the possiblility of EXPLOSION. It is best purified by distilling from P2O5 slowly, and collecting the fraction boiling at 39.5o. Store it in a dry atmosphere. Highly TOXIC vapour and attacks skin, work in an efficient fume hood. [Beilstein 2 IV 469.]
Trifluoroacetic anhydride Preparation Products And Raw materials
Raw materials
Preparation Products
1-[4-(TRIFLUOROMETHYL)PYRIMID-2-YL]PIPERAZINE
2-CYANO-4-PYRIDINE CARBOXYLIC ACID
2-Hydroxy-4-(trifluoromethyl)pyrimidine
5-Bromo-2-hydroxymethylpyridine
2-(4-Methylpiperazin-1-yl)-6-(trifluoromethyl)pyrimidine-4-carbonitrile
2-Chloro-4-(trifluoromethyl)pyrimidine
[BIS(TRIFLUOROACETOXY)IODO]PENTAFLUOROBENZENE
6-Aminobenzothiazole
2-HYDROXY-6-(TRIFLUOROMETHYL)NICOTINIC ACID
2-(4-Methylpiperazin-1-yl)-6-(trifluoromethyl)pyrimidine-4-carboxamide
(2-(4-Methylpiperazin-1-yl)-6-(trifluoromethyl)pyrimidin-4-yl)methanamine
2,6-DICHLORO-4-ISOCYANATOPYRIDINE
Ethyl 2-(4-hydroxypiperidin-1-yl)-6-(trifluoromethyl)pyrimidine-4-carboxylate
Ethyl 2-(4-(ethoxycarbonyl)piperidin-1-yl)-6-(trifluoromethyl)pyrimidine-4-carboxylate
Ethyl 2-(4-(hydroxymethyl)piperidin-1-yl)-6-(trifluoromethyl)pyrimidine-4-carboxylate
3-(Trifluoromethyl)pyrazole
1-METHYL-3-(TRIFLUOROMETHYL)-1H-PYRAZOLE
Chlorfenapyr
(2-(4-Methylpiperazin-1-yl)-6-(trifluoromethyl)pyrimidin-4-yl)methanol
3-(Trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazine
4-CHLORO-ALPHA-[METHYL(TRIFLUOROACETYL)AMINO]-BENZENEACETIC ACID
2-(METHYLTHIO)-4-(TRIFLUOROMETHYL)PYRIMIDINE
tert-Butyl 4-[4-(trifluoromethyl)pyrimidin-2-yl]piperazine-1-carboxylate ,97%
3-Nitroisonicotinic acid
Ethyl 2-(4-methylpiperazin-1-yl)-6-(trifluoromethyl)pyrimidine-4-carboxylate
3-(Trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine
5-Iodo-2,4-dimethoxypyrimidine
N10-(TRIFLUOROACETYL)PTEROIC ACID
3-Amino-4-nitrobenzitrifluoride
2-(TRIFLUOROACETYL)THIOPHENE
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Global( 554)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| CD Chemical Group Limited | +8615986615575 | info@codchem.com | China | 20342 | 58 |
| Shaanxi Didu New Materials Co. Ltd | +86-89586680 +86-13289823923 | 1026@dideu.com | China | 8670 | 58 |
| Hebei Weibang Biotechnology Co., Ltd | +8615531157085 | abby@weibangbio.com | China | 8810 | 58 |
| Hebei Chuanghai Biotechnology Co,.LTD | +86-13131129325 | sales1@chuanghaibio.com | China | 5889 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29791 | 60 |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 | info@dakenam.com | China | 18751 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21634 | 55 |
| Shanghai Time Chemicals CO., Ltd. | +86-021-57951555 +8617317452075 | jack.li@time-chemicals.com | China | 1803 | 55 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418679 +8618949832763 | info@tnjchem.com | China | 2986 | 55 |
| Zjartschem | +86-571 87238903 | jocelynpan@zjarts.com | CHINA | 988 | 58 |
Related articles
- Trifluoroacetic anhydride: Properties and applications
- Trifluoroacetic anhydride is a strong electron acceptor, which is often mixed with sodium iodide to form the acceptor reagent.
- Jul 7，2023
- Trifluoroacetic anhydride- an important organic reagent
- Trifluoroacetic anhydride (TFAA) is a colorless liquid with a vinegar odor and a volatile color. It has strong acidity and tri....
- Nov 11，2019
View Lastest Price from Trifluoroacetic anhydride manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-12-20 | Trifluoroacetic anhydride
407-25-0
|
US $0.00 / KG | 1KG | 99% | 500mt | Jinan Finer Chemical Co., Ltd | |
 |
2024-11-13 | Trifluoroacetic anhydride
407-25-0
|
US $19.90 / kg | 1kg | 99% | 10 mt | Hebei Weibang Biotechnology Co., Ltd | |
 |
2024-10-11 | Trifluoroacetic Anhydride
407-25-0
|
US $10.00 / KG | 1KG | 99.7% | 10 ton | Hebei Chuanghai Biotechnology Co,.LTD |
-
- Trifluoroacetic anhydride
407-25-0
- US $0.00 / KG
- 99%
- Jinan Finer Chemical Co., Ltd
-
- Trifluoroacetic anhydride
407-25-0
- US $19.90 / kg
- 99%
- Hebei Weibang Biotechnology Co., Ltd
-
- Trifluoroacetic Anhydride
407-25-0
- US $10.00 / KG
- 99.7%
- Hebei Chuanghai Biotechnology Co,.LTD
407-25-0(Trifluoroacetic anhydride)Related Search:
Glutaric anhydride
Ethyl trifluoroacetate
Succinic anhydride
Isatoic Anhydride
Trifluoromethanesulfonic anhydride
Phthalic anhydride
CIS-BUTENEDIOIC ANHYDRIDE
Trifluoroacetic acid
Sodium trifluoroacetate
Potassium trifluoroacetate
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TRIFLUOROACETO ANHYDRIDE
Trifluoroacetic acid anhydride (TFAH)
RIFLUOROACETIC ANHYDRIDE
Trifluoroacetic anhydride 10g [407-25-0]
Trifluoroacetic anhydride, min. 98%
trifluoroacetyl 2,2,2-trifluoroacetate
Trifluoroacetic anhydride, 99+% 100GR
Trifluoroacetic anhydride, 99+% 25GR
Trifluoracetic anhydride, min. 98%
Bis(2,2,2-trifluoroacetic acid)anhydride
Bis(trifluoroacetic acid) anhydride
Di(trifluoroacetic)anhydride
Trifluoroacetyltrifluoroacetate
Trifluoroethanoicanhydride
TRIFLUOROACETIC ANHYDRIDE
BIS(TRIFLUOROACETIC) ANHYDRIDE
Triflyuoroacetic anhydride
Aceticacid,trifluoro-,anhydride
Anhydrid kyseliny trifluoroctove
anhydridkyselinytrifluoroctove
Hexafluoroacetic anhydride
hexafluoroaceticanhydride
Perfluoroacetic anhydride
perfluoroaceticanhydride
TRIFLUOROACETIC ANHYDRIDE, REAGENTPLUS, >=99%
TRIFLUOROACETIC ANHYDRIDE, DERIVATIZA-TI ON REAGENT
TRIFLUOROACETIC ANHYDRIDE REAGENTPLUS(&
TrifluoroaceticAnhydride/Tfaa/Tfah/Trifluoroaceticanhydride
TrifluoroaceticAnhydride/Tfaa
Trifluoroacetic anhydride, 99+%
Trifluoraceticanhydride,min.98%
TRIFLUOROACETICANHYDRIDE,REAGENT
Trifluoressigsureanhydrid
Perfluoracetic anhydride
TRIFLUOROACETIC ANHYDRIDE: 99.5%
TRIFLUOROACETIC ANHYDRIDE FOR SYNTHESIS
TRIFLUOROACETIC ANHYDRIDE FOR GAS CHROMA
Trifluoroacetic anhydride 99%
TRIFLUOROACETIC ANHYDRINE
TFAH)Trifluoroacetic anhyd
1,1,1,5,5,5-Hexafluoro-3-oxapentan-2,4-dione, Perfluoro(3-oxapentan-2,4-dione), 2,2,2-Trifluoroethanoic anhydride
Aceticacid, 2,2,2-trifluoro-, 1,1'-anhydride
Three fluorineacetic anhydride
trimethylamine (TMA)
Trifluoroacetic anhydride ReagentPlus(R), >=99%
Trifluoroacetyl 2,2,2-trifluoroacetate (Trifluoroacetic anhydride)
Trifluoroacetic anhydride≥ 99% (GC)
TFAA
Trifluoroacetic acid anhydride
trifluoro-aceticacianhydride
Trifluoroacetyl anhydride
trifluoroacetylanhydride
Trifluoroacetic Anhydride >
Trifluoroacetic Anhydride (Reagent), Fisher Chemical
Trifluoroacetic Anhydride, 99&plus
uoroacetic anhydride
Trifluoroacetic anhydride 407-25-0 fiona
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