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ChemicalBook >> CAS DataBase List >>Pyrano[2,3-c]pyrazole-5-carbonitrile, 6-amino-1,4-dihydro-4-[5-(hydroxymethyl)[1,1'-biphenyl]-3-yl]-3-methyl-4-(1-methylethyl)-, (4R)-

Pyrano[2,3-c]pyrazole-5-carbonitrile, 6-amino-1,4-dihydro-4-[5-(hydroxymethyl)[1,1'-biphenyl]-3-yl]-3-methyl-4-(1-methylethyl)-, (4R)-

CAS No.
2443966-90-1
Chemical Name:
Pyrano[2,3-c]pyrazole-5-carbonitrile, 6-amino-1,4-dihydro-4-[5-(hydroxymethyl)[1,1'-biphenyl]-3-yl]-3-methyl-4-(1-methylethyl)-, (4R)-
Synonyms
Pyrano[2,3-c]pyrazole-5-carbonitrile, 6-amino-1,4-dihydro-4-[5-(hydroxymethyl)[1,1'-biphenyl]-3-yl]-3-methyl-4-(1-methylethyl)-, (4R)-
CBNumber:
CB68231763
Molecular Formula:
C24H24N4O2
Molecular Weight:
400.47
MDL Number:
MOL File:
2443966-90-1.mol
Last updated:2025-04-18 09:52:34

Pyrano[2,3-c]pyrazole-5-carbonitrile, 6-amino-1,4-dihydro-4-[5-(hydroxymethyl)[1,1'-biphenyl]-3-yl]-3-methyl-4-(1-methylethyl)-, (4R)- Properties

Boiling point 683.6±55.0 °C(Predicted)
Density 1.32±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMSO: ≥ 100 mg/mL (249.71 mM)
pka 11.54±0.70(Predicted)
form Solid
color White to off-white

Pyrano[2,3-c]pyrazole-5-carbonitrile, 6-amino-1,4-dihydro-4-[5-(hydroxymethyl)[1,1'-biphenyl]-3-yl]-3-methyl-4-(1-methylethyl)-, (4R)- Chemical Properties,Uses,Production

Uses

(+)-SHIN1 ((+)-RZ-2994) is an active (+) enantiomer of SHIN1[1].

References

[1] Ducker GS, et al. Human SHMT inhibitors reveal defective glycine import as a targetable metabolic vulnerability of diffuse large B-cell lymphoma. Proc Natl Acad Sci U S A. 2017 Oct 24;114(43):11404-11409. DOI:10.1073/pnas.1706617114

Pyrano[2,3-c]pyrazole-5-carbonitrile, 6-amino-1,4-dihydro-4-[5-(hydroxymethyl)[1,1'-biphenyl]-3-yl]-3-methyl-4-(1-methylethyl)-, (4R)- Preparation Products And Raw materials

Raw materials

Preparation Products

Pyrano[2,3-c]pyrazole-5-carbonitrile, 6-amino-1,4-dihydro-4-[5-(hydroxymethyl)[1,1'-biphenyl]-3-yl]-3-methyl-4-(1-methylethyl)-, (4R)- Suppliers

Global( 5)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc. 		support@targetmol.com United States 38664 58
TargetMol Chemicals Inc. 		+8613564774135 zijue.cai@tsbiochem.com United States 19906 58
RD International Technology Co., Limited 18024082417 market@ubiochem.com China 9835 58
TargetMol Chemicals Inc. 15002134094 marketing@targetmol.cn China 20036 58
Biosynth Biological Technology (Suzhou) Co Ltd 51288865780 sales@biosynth.com China 233051 58

View Lastest Price from Pyrano[2,3-c]pyrazole-5-carbonitrile, 6-amino-1,4-dihydro-4-[5-(hydroxymethyl)[1,1'-biphenyl]-3-yl]-3-methyl-4-(1-methylethyl)-, (4R)- manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
(+)-SHIN1 pictures 2024-11-19 (+)-SHIN1
2443966-90-1
 US $1920.00-1470.00 / mg 10g TargetMol Chemicals Inc.
  • (+)-SHIN1 pictures
  • (+)-SHIN1
    2443966-90-1
  • US $1920.00-1470.00 / mg
  • TargetMol Chemicals Inc.
Pyrano[2,3-c]pyrazole-5-carbonitrile, 6-amino-1,4-dihydro-4-[5-(hydroxymethyl)[1,1'-biphenyl]-3-yl]-3-methyl-4-(1-methylethyl)-, (4R)- 2443966-90-1