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ChemicalBook >> CAS DataBase List >>SB 215505

SB 215505

CAS No.
162100-15-4
Chemical Name:
SB 215505
Synonyms
SB 215505,SB215505;6-Chloro-5-methyl-N-(quinolin-5-yl)indoline-1-carboxamide;6-chloro-5-methyl-N-quinolin-5-yl-2,3-dihydroindole-1-carboxamide;6-Chloro-2,3-dihydro-5-methyl-N-5-quinolinyl-1H-indole-1-carboxamide;1H-Indole-1-carboxamide, 6-chloro-2,3-dihydro-5-methyl-N-5-quinolinyl-
CBNumber:
CB6497099
Molecular Formula:
C19H16ClN3O
Molecular Weight:
337.8
MDL Number:
MFCD05664741
MOL File:
162100-15-4.mol
Last updated:2025-04-17 18:22:24

SB 215505 Properties

Boiling point 600.9±55.0 °C(Predicted)
Density 1.385±0.06 g/cm3(Predicted)
storage temp. 2-8°C
solubility DMSO: ~11 mg/mL at 60 °C, soluble
pka 12.87±0.20(Predicted)
form solid
color off-white
UNSPSC Code 12352200
NACRES NA.77

SAFETY

Risk and Safety Statements

WGK Germany  3

SB 215505 price More Price(9)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TRC S155013 SB-215505 162100-15-4 10mg $285 2021-12-16 Buy
American Custom Chemicals Corporation BRS0000721 SB-215505 95.00% 162100-15-4 5MG $781.36 2021-12-16 Buy
American Custom Chemicals Corporation BRS0000721 SB-215505 95.00% 162100-15-4 25MG $1262.48 2021-12-16 Buy
Ambeed A973943 6-Chloro-5-methyl-N-(quinolin-5-yl)indoline-1-carboxamide 98% 162100-15-4 5mg $1420 2021-12-16 Buy
Ambeed A973943 6-Chloro-5-methyl-N-(quinolin-5-yl)indoline-1-carboxamide 98% 162100-15-4 10mg $1851 2021-12-16 Buy
Product number Packaging Price Buy
S155013 10mg $285 Buy
BRS0000721 5MG $781.36 Buy
BRS0000721 25MG $1262.48 Buy
A973943 5mg $1420 Buy
A973943 10mg $1851 Buy

SB 215505 Chemical Properties,Uses,Production

Uses

SB-215505 is a selective 5-HT2B serotonin receptor antagonist.

Biological Activity

Selective 5-HT2B serotonin receptor antagonist; 100-fold higher affinity at 2B versus 2C.

in vivo

SB-215505 (0.1-1.0 mg/kg; i.p.; two doses) dose-dependently increases wakefulness (W) and decreases IS, PS, SWS-2[2].

Animal Model:Male Sprague-Dawley rats weighing 230-260 g[2]
Dosage:0.1, 0.3 and 1.0 mg/kg
Administration:IP; two doses (4 days between two doses)
Result:Dose-dependently increased wakefulness (W) and decreased intermediate stage of sleep (IS), paradoxical sleep (PS), SWS-2.

IC 50

5-HT2B Receptor: 8.3 (pKi); 5-HT2A Receptor: 6.77 (pKi); 5-HT2C Receptor: 7.66 (pKi)

SB 215505 Preparation Products And Raw materials

Raw materials

Preparation Products

SB 215505 Suppliers

Global( 22)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32159 58
Wuhan Jingkang en Biomedical Technology Co., Ltd 		+8613720134139 orders@jknbiochem.com China 5221 58
Shanghaizehan biopharma technology co., Ltd. 021-61350663 13052117465 sales@zehanbiopharma.com China 996 55
Shanghai EFE Biological Technology Co., Ltd. 021-65675885 18964387627 info@efebio.com China 9803 58
Shanghai Hongye Biotechnology Co. Ltd 400-9205774 sales@glpbio.cn China 6777 58
Jiangsu aikang biomedical research and development co., LTD 025-66110311 13155353615 qzhang@aikonchem.com China 15526 58
BOC Sciences -- info@bocsci.com USA 0 65
Energy Chemical 021-58432009 400-005-6266 marketing1@energy-chemical.com China 44812 58
Beijing Jin Ming Biotechnology Co., Ltd. 010-60605840 15801484223; psaitong@jm-bio.com China 29774 58
Bide Pharmatech Ltd. 400-1647117 13681763483 product02@bidepharm.com China 62072 58
6-Chloro-2,3-dihydro-5-methyl-N-5-quinolinyl-1H-indole-1-carboxamide 6-chloro-5-methyl-N-quinolin-5-yl-2,3-dihydroindole-1-carboxamide 1H-Indole-1-carboxamide, 6-chloro-2,3-dihydro-5-methyl-N-5-quinolinyl- 6-Chloro-5-methyl-N-(quinolin-5-yl)indoline-1-carboxamide SB 215505,SB215505 162100-15-4 C19H16N3OCl