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ChemicalBook >> CAS DataBase List >>(3E)-3-[(2,4-dimethoxyphenyl)methylidene]-1H-indol-2-one

(3E)-3-[(2,4-dimethoxyphenyl)methylidene]-1H-indol-2-one

CAS No.
856435-40-0
Chemical Name:
(3E)-3-[(2,4-dimethoxyphenyl)methylidene]-1H-indol-2-one
Synonyms
MDM2p53IN1b;MDM2-p53-IN-1b;MDM2 p53 IN 1b;MDM2-p53 inhibitor 1b;Antiproliferative agent-62;MDM-2-p53-IN-1b,MDM2p53IN1b;(3E)-3-[(2,4-dimethoxyphenyl)methylidene]-1H-indol-2-one;2H-Indol-2-one, 3-[(2,4-dimethoxyphenyl)methylene]-1,3-dihydro-, (3E)-
CBNumber:
CB64617871
Molecular Formula:
C17H15NO3
Molecular Weight:
281.31
MDL Number:
MOL File:
856435-40-0.mol
Last updated:2025-04-17 18:22:24

(3E)-3-[(2,4-dimethoxyphenyl)methylidene]-1H-indol-2-one Properties

Melting point 210-211 °C
Boiling point 518.7±50.0 °C(Predicted)
Density 1.240±0.06 g/cm3(Predicted)
pka 12.74±0.20(Predicted)

(3E)-3-[(2,4-dimethoxyphenyl)methylidene]-1H-indol-2-one price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
American Custom Chemicals Corporation CHM0288446 (3E)-3-[(2,4-DIMETHOXYPHENYL)METHYLIDENE]-1H-INDOL-2-ONE 95.00% 856435-40-0 5MG $505.36 2021-12-16 Buy
Product number Packaging Price Buy
CHM0288446 5MG $505.36 Buy

(3E)-3-[(2,4-dimethoxyphenyl)methylidene]-1H-indol-2-one Chemical Properties,Uses,Production

Description

MDM2-p53-IN-1b is an inhibitor of the MDM2-p53 interaction.

Uses

Antiproliferative agent-62 is a functionalized benzylidene-indolin-2-one with notable antiproliferative activity, particularly in inducing NQO1 expression in murine Hepa1c1c7 cells and demonstrating effectiveness against human cancer cell lines, including MCF-7 and HCT116.

References

[1] Functionalized 3-benzylidene-indolin-2-ones: inducers of NAD(P)H-quinone oxidoreductase 1 (NQO1) with antiproliferative activity

(3E)-3-[(2,4-dimethoxyphenyl)methylidene]-1H-indol-2-one Preparation Products And Raw materials

Raw materials

Preparation Products

(3E)-3-[(2,4-dimethoxyphenyl)methylidene]-1H-indol-2-one Suppliers

Global( 5)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc. 		+17819995354 marketing@targetmol.com United States 32285 58
TargetMol Chemicals Inc. 		+17819995354 marketing@targetmol.com United States 19904 58
TargetMol Chemicals Inc. 15002134094 marketing@targetmol.cn China 21356 58
Shaoguan Qicheng Biotechnology Co., Ltd 18122215013 780229652@qq.com China 1266 58

View Lastest Price from (3E)-3-[(2,4-dimethoxyphenyl)methylidene]-1H-indol-2-one manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
MDM2-p53-IN-1b pictures 2024-10-24 MDM2-p53-IN-1b
856435-40-0
 US $2500.00-1520.00 / mg 10g TargetMol Chemicals Inc.
  • MDM2-p53-IN-1b pictures
  • MDM2-p53-IN-1b
    856435-40-0
  • US $2500.00-1520.00 / mg
  • TargetMol Chemicals Inc.
(3E)-3-[(2,4-dimethoxyphenyl)methylidene]-1H-indol-2-one MDM2 p53 IN 1b MDM2-p53 inhibitor 1b MDM2p53IN1b MDM2-p53-IN-1b MDM-2-p53-IN-1b,MDM2p53IN1b 2H-Indol-2-one, 3-[(2,4-dimethoxyphenyl)methylene]-1,3-dihydro-, (3E)- Antiproliferative agent-62 856435-40-0