T-26c
- CAS No.
- 869296-13-9
- Chemical Name:
- T-26c
- Synonyms
- T-26c;CPD1612;T-26c >=98% (HPLC);T-26c, 10 mM in DMSO;T26c,Inhibitor,Matrix metalloproteinases,MMP,T-26c,T 26c,inhibit;4-(((2-((3-Methoxybenzyl)carbamoyl)-4-oxo-1,4-dihydrothieno[2,3-d]pyrimidin-5-yl)methoxy)methyl)benzoic acid;Benzoic acid, 4-[[[1,4-dihydro-2-[[[(3-methoxyphenyl)methyl]amino]carbonyl]-4-oxothieno[2,3-d]pyrimidin-5-yl]methoxy]methyl]-
- CBNumber:
- CB63381025
- Molecular Formula:
- C24H21N3O6S
- Molecular Weight:
- 479.51
- MDL Number:
- MFCD31558511
- MOL File:
- 869296-13-9.mol
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
T-26c price More Price(14)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 19962 | T-26c | 869296-13-9 | 5mg | $120 | 2024-03-01 | Buy |
| Cayman Chemical | 19962 | T-26c | 869296-13-9 | 10mg | $220 | 2024-03-01 | Buy |
| Cayman Chemical | 19962 | T-26c | 869296-13-9 | 1mg | $38 | 2024-03-01 | Buy |
| ChemScene | CS-0019657 | T-26c 99.40% | 869296-13-9 | 5mg | $120 | 2021-12-16 | Buy |
| ChemScene | CS-0019657 | T-26c 99.40% | 869296-13-9 | 10mg | $190 | 2021-12-16 | Buy |
T-26c Chemical Properties,Uses,Production
Uses
T-26c is highly potent and selective matrix metalloproteinase-13 (MMP-13) inhibitor with an IC50 of 6.75 pM and more than 2600-fold selectivity over the other related metalloenzymes[1].
Biological Activity
T-26c is a highly potent, selective and cell-permeable matrix metalloproteinases 13 (MMP-13) inhibitor. T-26c inhibits the breakdown of collagen (87.4% inhibition at 0.1 μM) in IL-1b and oncostatin M stimulated cartilage. For full characterization details, please visit the T-26c probe summary on the Structural Genomics Consortium (SGC) website.
To learn about other SGC chemical probes for protein targets, visit sigma.com/sgc
in vivo
T-26c is well absorbed in all species at the oral dose of 10–20 mg/kg. Oral administration of the disodium salt formulations of T-26c to guinea pigs results in significant increases in AUC (8357 ng h/mL) and Cmax (1445 ng/ mL) compared with those of the free acid T-26c (AUC = 6478 ng h/ mL and Cmax= 911 ng/mL)[1].
References
[1] Nara H, et al. Thieno[2,3-d]pyrimidine-2-carboxamides bearing a carboxybenzene group at 5-position: highly potent, selective, and orally available MMP-13 inhibitors interacting with the S1″ binding site. Bioorg Med Chem. 2014 Oct 1;22(19):5487-505. DOI:10.1016/j.bmc.2014.07.025
T-26c Preparation Products And Raw materials
Raw materials
Preparation Products
T-26c Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32268 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | laboratory@coreychem.com | China | 30230 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
| TargetMol Chemicals Inc. | support@targetmol.com | United States | 38664 | 58 | |
| Jilin Chinese Academy of Sciences-yanshen Technology | +undefined18143011203 | info@chemextension.com | China | 42056 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 57505 | 58 | |
| Shanghai Luofa Biochemical Technology Co., Ltd. | 021-51111890 15317326293 | sales@molnova.com | China | 4195 | 58 |
| ShangHai Caerulum Pharma Discovery Co., Ltd. | 18149758185 18149758185 | sales-cpd@caerulumpharma.com | China | 3466 | 58 |
| Sichuan Wei Keqi Biological Technology Co., Ltd. | 028-81700200 18116577057 | 3003855609@qq.com | China | 7787 | 56 |
