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ChemicalBook >> CAS DataBase List >>CCT251455

CCT251455

CAS No.
1400284-80-1
Chemical Name:
CCT251455
Synonyms
CCT251455;CCT251455,CCT-251455;BXKNUXDLZJPPBO-UHFFFAOYSA-N;1H-Pyrrolo[3,2-c]pyridine-1-carboxylic acid, 6-[[2-chloro-4-(1-methyl-1H-imidazol-5-yl)phenyl]amino]-2-(1-methyl-1H-pyrazol-4-yl)-, 1,1-dimethylethyl ester
CBNumber:
CB63339864
Molecular Formula:
C26H26ClN7O2
Molecular Weight:
503.98
MDL Number:
MFCD28399124
MOL File:
1400284-80-1.mol
Last updated:2025-04-18 09:51:22

CCT251455 Properties

Boiling point 731.0±70.0 °C(Predicted)
Density 1.34±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
solubility Soluble in DMSO
form Solid
pka 7.86±0.30(Predicted)
color Light yellow to brown

CCT251455 Chemical Properties,Uses,Production

Description

CCT251455 is a potent and selecltive MSP1 inhibitor with potential anticancer activitiy. The protein kinase MPS1 is a crucial component of the spindle assembly checkpoint signal and is aberrantly overexpressed in many human cancers. MPS1 is one of the top 25 genes overexpressed in tumors with chromosomal instability and aneuploidy. PTEN-deficient breast tumor cells are particularly dependent upon MPS1 for their survival, making it a target of significant interest in oncology. CCT251455 stabilizes an inactive conformation of MPS1 with the activation loop ordered in a manner incompatible with ATP and substrate-peptide binding; it displays a favorable oral pharmacokinetic profile, shows dose-dependent inhibition of MPS1 in an HCT116 human tumor xenograft model, and is an attractive tool compound to elucidate further the therapeutic potential of MPS1 inhibition.

Uses

CCT251455 is a potent and selective mitotic kinase monopolar spindle 1 (MPS1) inhibitor with an IC50 of 3 nM.

in vivo

CCT251455 demonstrates a good oral pharmacokinetic profile in mouse and rat as well as inhibition of MPS1 activity in vivo following oral administration[1].

References

[1] Naud S, et al. Structure-based design of orally bioavailable 1H-pyrrolo[3,2-c]pyridine inhibitors of mitotic kinase monopolar spindle 1 (MPS1). J Med Chem. 2013 Dec 27;56(24):10045-65. DOI:10.1021/jm401395s

1400287-23-1
1400286-74-9
1400284-80-1
Synthesis of CCT251455 from 2-chloro-4-(1-methyl-1H-imidazol-5-yl)aniline and t-butyl 6-bromo-2-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridine-1-carboxylate

CCT251455 Suppliers

Global( 12)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc.
+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32275 58
TargetMol Chemicals Inc.
support@targetmol.com United States 38664 58
Aladdin Scientific
tp@aladdinsci.com United States 52924 58
TargetMol Chemicals Inc.
+8613564774135 zijue.cai@tsbiochem.com United States 19905 58
Fan De(Beijing) Biotechnology Co., Ltd. 15911056312 liming@bio-fount.com China 9729 58
ShangHai ChuanQian Chemcial Technique Centre 15869524721 3525679403@qq.com China 4487 58
cjbscvictory 13348960310 13348960310 3003867561@qq.com China 10523 58
TargetMol Chemicals Inc. 4008200310 marketing@tsbiochem.com China 24874 58
RD International Technology Co., Limited 18024082417 market@ubiochem.com China 9835 58
ABBIOCHEM 18964309092 18964309092 2769493375@qq.com China 919 58

View Lastest Price from CCT251455 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
CCT251455 pictures 2024-10-28 CCT251455
1400284-80-1
US $2380.00-1820.00 / mg 10g TargetMol Chemicals Inc.
  • CCT251455 pictures
  • CCT251455
    1400284-80-1
  • US $2380.00-1820.00 / mg
  • TargetMol Chemicals Inc.
CCT251455 BXKNUXDLZJPPBO-UHFFFAOYSA-N CCT251455,CCT-251455 1H-Pyrrolo[3,2-c]pyridine-1-carboxylic acid, 6-[[2-chloro-4-(1-methyl-1H-imidazol-5-yl)phenyl]amino]-2-(1-methyl-1H-pyrazol-4-yl)-, 1,1-dimethylethyl ester 1400284-80-1