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ChemicalBook >> CAS DataBase List >>LIMK1 inhibitor BMS 4

LIMK1 inhibitor BMS 4

CAS No.
905298-84-2
Chemical Name:
LIMK1 inhibitor BMS 4
Synonyms
LIMK1 inhibitor BMS 4;LIMK1 inhibitor BMS 4 - BMS 4;Urea, N-ethyl-N'-[5-[6-(4-methoxy-2,6-dimethylphenyl)-2-(2-pyrazinyl)-4-pyrimidinyl]-2-thiazolyl]-;1-ethyl-3-[5-[6-(4-methoxy-2,6-dimethylphenyl)-2-pyrazin-2-ylpyrimidin-4-yl]-1,3-thiazol-2-yl]urea
CBNumber:
CB63146323
Molecular Formula:
C23H23N7O2S
Molecular Weight:
461.54
MDL Number:
MFCD24387531
MOL File:
905298-84-2.mol
Last updated:2025-04-29 09:03:59

LIMK1 inhibitor BMS 4 Properties

Melting point 274-276 °C
Density 1.297±0.06 g/cm3(Predicted)
pka 8.63±0.70(Predicted)
form Solid
color White to off-white

LIMK1 inhibitor BMS 4 price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Axon Medchem Axon1949 LIMK1inhibitorBMS4-BMS4 99% 905298-84-2 5mg $192.5 2021-12-16 Buy
Product number Packaging Price Buy
Axon1949 5mg $192.5 Buy

LIMK1 inhibitor BMS 4 Chemical Properties,Uses,Production

Uses

LIMK1 inhibitor BMS-4 is a LIM Kinase (LIMK) inhibitor targeting to LIMK1/2. LIMK1 inhibitor BMS-4 inhibits phosphorylation of cofilin, the LIMK substrate. However, LIMK1 inhibitor BMS-4 is noncytotoxic on A549 cells[1][2].

IC 50

LIMK1: 7.25 (pIC50); LIMK2: 6.87 (pIC50)

References

[1] Collins R, et al. Comparative Analysis of Small-Molecule LIMK1/2 Inhibitors: Chemical Synthesis, Biochemistry, and Cellular Activity. J Med Chem. 2022 Oct 27;65(20):13705-13713. DOI:10.1021/acs.jmedchem.2c00751
[2] Ross-Macdonald P, et al. Identification of a nonkinase target mediating cytotoxicity of novel kinase inhibitors. Mol Cancer Ther. 2008 Nov;7(11):3490-8. DOI:10.1158/1535-7163.MCT-08-0826

LIMK1 inhibitor BMS 4 Preparation Products And Raw materials

Raw materials

Preparation Products

LIMK1 inhibitor BMS 4 Suppliers

Global( 9)Suppliers
Supplier Tel Email Country ProdList Advantage
Aladdin Scientific 		tp@aladdinsci.com United States 52924 58
TargetMol Chemicals Inc. 		+8613564774135 zijue.cai@tsbiochem.com United States 19906 58
Shanghai EFE Biological Technology Co., Ltd. 021-65675885 18964387627 info@efebio.com China 9803 58
BOC Sciences -- info@bocsci.com USA 0 65
Jinan Jiuli Biotechnology Co. , Ltd. 15865264761 486064515@qq.com China 4765 58
Nantong Hanfang Biotechnology Co. , Ltd. hanfangpharma@126.com; 18616537568 hanfangpharma@126.com China 29981 58
TargetMol Chemicals Inc. 15002134094 marketing@targetmol.cn China 20036 58
Biosynth Biological Technology (Suzhou) Co Ltd 51288865780 sales@biosynth.com China 233051 58

View Lastest Price from LIMK1 inhibitor BMS 4 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
LIMK1 inhibitor BMS-4 pictures 2025-04-29 LIMK1 inhibitor BMS-4
905298-84-2
 US $2180.00-2800.00 / mg 10g TargetMol Chemicals Inc.
LIMK1 inhibitor BMS 4 LIMK1 inhibitor BMS 4 - BMS 4 1-ethyl-3-[5-[6-(4-methoxy-2,6-dimethylphenyl)-2-pyrazin-2-ylpyrimidin-4-yl]-1,3-thiazol-2-yl]urea Urea, N-ethyl-N'-[5-[6-(4-methoxy-2,6-dimethylphenyl)-2-(2-pyrazinyl)-4-pyrimidinyl]-2-thiazolyl]- 905298-84-2 C23H23N7O2S