Aducanumab
- CAS No.
- 1384260-65-4
- Chemical Name:
- Aducanumab
- Synonyms
- BIIB037;Aducanumab;Aducanumab (anti-APP);Research Grade Aducanumab(DHC12504);AducanumabQ: What is Aducanumab Q: What is the CAS Number of Aducanumab
- CBNumber:
- CB63143751
- Molecular Formula:
- Molecular Weight:
- 0
- MDL Number:
- MOL File:
- Mol file
storage temp. | Store at -80°C, Aliquots should be stored at the same temperature after first use to avoid multiple freeze-thaws |
---|---|
form | Liquid |
color | Colorless to light yellow |
FDA UNII | 105J35OE21 |
Aducanumab Chemical Properties,Uses,Production
Enzyme inhibitor
This high-affinity, fully human IgG1 monoclonal antibody (MW = 149.5 kDa; CAS 1384260-65-4), also known by the developmental code name BIIB037, selectively targets aggregated forms of b-amyloid protein (EC50 = 0.1 nM), while showing weak binding to Ab monomer. In the brains of transgenic mice, aducanumab preferentially binds to parenchymal Aβ over vascular Aβ deposits, consistent with the lack of effect on vascular Aβ following chronic dosing. Aducanumab dose-dependently reduces amyloid deposition in six cortical regions of the brain. chAducanumab, a murine IgG2a/κ chimeric analogue, dose-dependently reduces Aβ measured in brain homogenates by up to 50% relative to the vehicle control in the diethylamine fraction that extracted soluble monomeric and oligomeric forms of Aβ40 and Aβ42, and in the guanidine hydrochloride fraction that extracted insoluble Aβ fibrils. The clearance of Aβ deposits was accompanied by enhanced recruitment of microglia. Together with the reduced potency of the aglycosylated form of chaducanumab and the ex vivo phagocytosis data, such findings suggest that FcγR-mediated microglial recruitment and phagocytosis played an important role in Aβ clearance in these models. Activated microglia appeared to encapsulate the remaining central dense core of plaques in treated animals, possibly isolating them from the surrounding neurophil.
Aducanumab Preparation Products And Raw materials
Raw materials
Preparation Products
Aducanumab Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21634 | 55 |
TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32161 | 58 |
Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 57505 | 58 |
Nanjing Sunlida Biological Technology Co., Ltd. | 025-57798810 | sales@sunlidabio.com | China | 3239 | 55 |
Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9806 | 58 |
ShangHai Biochempartner Co.,Ltd | 177-54423994 17754423994 | 2853530910@QQ.com | China | 8012 | 62 |
Nanjing Peptide Biotech Ltd. | 025-025-58361106-805-805 13082558573 | liugang@njpeptide.com | China | 9980 | 55 |
Nanjing Meihao Pharmaceutical Technology Co., Ltd. | meitaochem@126.com | meitaochem@126.com | China | 19103 | 58 |
Guangzhou Hongyuan Chemical Co.,Ltd | 15817493340 | 981810490@qq.com | China | 1566 | 58 |
Wuhan Chemstan Biotechnology Co., Ltd. | 027-65317797 15926423062 | 422450190@qq.com | China | 10424 | 58 |
View Lastest Price from Aducanumab manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2024-11-19 | Aducanumab
1384260-65-4
|
US $189.00-813.00 / mg | 97.1% (SEC-HPLC) | 10g | TargetMol Chemicals Inc. |
- Aducanumab
1384260-65-4
- US $189.00-813.00 / mg
- 97.1% (SEC-HPLC)
- TargetMol Chemicals Inc.