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ChemicalBook >> CAS DataBase List >>BTZ043 (BTZ038, BTZ044)

BTZ043 (BTZ038, BTZ044)

CAS No.
957217-65-1
Chemical Name:
BTZ043 (BTZ038, BTZ044)
Synonyms
BTZ038;BTZ044;BTZ 10526038;BTZ038; BTZ044;BTZ043 (BTZ038, BTZ044);Benzothiazinone 10526038;BTZ043 Racemate, 10 mM in DMSO;BTZ043 (BTZ038, BTZ044) Racemate;2-(3-methyl-1,4-dioxa-8-azaspiro[4.5]decan-8-yl)-8-nitro-6-(trifluoromethyl)-1,3-benzothiazin-4-one;4H-1,3-Benzothiazin-4-one, 2-(2-methyl-1,4-dioxa-8-azaspiro[4.5]dec-8-yl)-8-nitro-6-(trifluoromethyl)-
CBNumber:
CB62650632
Molecular Formula:
C17H16F3N3O5S
Molecular Weight:
431.39
MDL Number:
MFCD22420808
MOL File:
957217-65-1.mol
Last updated:2025-04-17 18:22:24

BTZ043 (BTZ038, BTZ044) Properties

Boiling point 547.6±60.0 °C(Predicted)
Density 1.68±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
solubility insoluble in H2O; ≥10.4 mg/mL in DMSO with gentle warming; ≥3.27 mg/mL in EtOH with gentle warming and ultrasonic
form solid
pka -0.51±0.20(Predicted)
color White to light yellow

BTZ043 (BTZ038, BTZ044) price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
ChemScene CS-0019700 BTZ043(Racemate) 98.77% 957217-65-1 5mg $90 2021-12-16 Buy
ChemScene CS-0019700 BTZ043(Racemate) 98.77% 957217-65-1 10mg $125 2021-12-16 Buy
ApexBio Technology A5118 BTZ043Racemate 957217-65-1 5mg $126 2021-12-16 Buy
ApexBio Technology A5118 BTZ043Racemate 957217-65-1 10mg $242 2021-12-16 Buy
ChemScene CS-0019700 BTZ043(Racemate) 98.77% 957217-65-1 50mg $440 2021-12-16 Buy
Product number Packaging Price Buy
CS-0019700 5mg $90 Buy
CS-0019700 10mg $125 Buy
A5118 5mg $126 Buy
A5118 10mg $242 Buy
CS-0019700 50mg $440 Buy

BTZ043 (BTZ038, BTZ044) Chemical Properties,Uses,Production

Uses

BTZ043 Racemate (BTZ10526038) is the racemate of BTZ043. BTZ043 is an inhibitor of decaprenyl-phosphoribose-epimerase (DprE1), and the antimicrobial activity of BTZ043 is more potent than BTZ043 Racemate[1].

Biological Activity

mic: 1 ng/ml (2.3 nm) for m. tuberculosis h37rv and 4 ng/ml (9.2 nm) for mycobacterium smegmatisthe loss of human lives to tuberculosis (tb) continues unabated as a result of poverty, synergy with the hiv/aids pandemic, and the emergence of multidrug- and extensively drug-resistant strains of mycobacterium tuberculosis. btz043 is the most advanced candidate for inclusion in combination therapies for both drug-sensitive and extensively drug-resistant tb.

in vitro

btz043 displayed similar activity against all clinical isolates of m. tuberculosis that were tested, including extensively drug-resistant and multidrug-resistant strains, indicating that it targets a previously unknown biological function. btz043 is bactericidal, reducing viability in vitro by more than 1000-fold in under 72 hours, which is comparable to the inh killing effect [1].

in vivo

the in vivo efficacy of btz043 was assessed 4 weeks after a low-dose aerosol infection of in the chronic balb/c mice model of tb. four weeks of treatment with btz043 reduced the bacterial load in the lungs and spleens by 1 and 2 logs, respectively, at the concentrations used. additional findings suggest that btz efficacy is time- rather than dose-dependent [1].

target

TargetValue
DprE1

References

[1] makarov v, manina g, mikusova k, et al. benzothiazinones kill mycobacterium tuberculosis by blocking arabinan synthesis. science. 2009 may 8;324(5928):801-4.

BTZ043 (BTZ038, BTZ044) Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 53)Suppliers
Supplier Tel Email Country ProdList Advantage
ATK CHEMICAL COMPANY LIMITED
+undefined-21-51877795 ivan@atkchemical.com China 33024 60
Career Henan Chemica Co
+86-0371-86658258 +8613203830695 laboratory@coreychem.com China 30230 58
InvivoChem
+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6391 58
TargetMol Chemicals Inc.
support@targetmol.com United States 38669 58
Wuhan Topule Biopharmaceutical Co., Ltd
+8618327326525 masar@topule.com China 8467 58
Aladdin Scientific
tp@aladdinsci.com United States 57505 58
BOC Sciences 1-631-485-4226; 16314854226 info@bocsci.com United States 12952 65
Dalian Meilun Biotech Co., Ltd. 0411-62910999 13889544652 sales@meilune.com China 4734 58
Shanghai Aladdin Bio-Chem Technology Co.,LTD 400-6206333 13167063860 anhua.mao@aladdin-e.com China 25003 65
AdooQ BioScience, LLC +1 (866) 930-6790 info@adooq.com United States 2782 58

BTZ043 (BTZ038, BTZ044) Spectrum

957217-65-1(BTZ043 (BTZ038, BTZ044))Related Search:

BTZ043 (BTZ038, BTZ044) 4H-1,3-Benzothiazin-4-one, 2-(2-methyl-1,4-dioxa-8-azaspiro[4.5]dec-8-yl)-8-nitro-6-(trifluoromethyl)- 2-(3-methyl-1,4-dioxa-8-azaspiro[4.5]decan-8-yl)-8-nitro-6-(trifluoromethyl)-1,3-benzothiazin-4-one BTZ043 Racemate Benzothiazinone 10526038 BTZ 10526038 2-(2-Methyl-1,4-dioxa-8-azaspiro[4.5]decan-8-yl)-8-nitro-6-(trifluoromethyl)-4H-benzo[e][1,3]thiazin-4-one 2-(3-methyl-1,4-dioxa-8-azaspiro[4.5]decan-8-yl)-8-nitro-6-(trifluoromethyl)-1,3-benzothiazin-4-one BTZ038 BTZ038; BTZ044 BTZ044 BTZ043 Racemate, 10 mM in DMSO BTZ043 (BTZ038, BTZ044) Racemate 957217-65-1 Inhibitors