BTZ043 (BTZ038, BTZ044)
- CAS No.
- 957217-65-1
- Chemical Name:
- BTZ043 (BTZ038, BTZ044)
- Synonyms
- BTZ038;BTZ044;BTZ 10526038;BTZ038; BTZ044;BTZ043 (BTZ038, BTZ044);Benzothiazinone 10526038;BTZ043 Racemate, 10 mM in DMSO;BTZ043 (BTZ038, BTZ044) Racemate;2-(3-methyl-1,4-dioxa-8-azaspiro[4.5]decan-8-yl)-8-nitro-6-(trifluoromethyl)-1,3-benzothiazin-4-one;4H-1,3-Benzothiazin-4-one, 2-(2-methyl-1,4-dioxa-8-azaspiro[4.5]dec-8-yl)-8-nitro-6-(trifluoromethyl)-
- CBNumber:
- CB62650632
- Molecular Formula:
- C17H16F3N3O5S
- Molecular Weight:
- 431.39
- MDL Number:
- MFCD22420808
- MOL File:
- 957217-65-1.mol
Boiling point | 547.6±60.0 °C(Predicted) |
---|---|
Density | 1.68±0.1 g/cm3(Predicted) |
storage temp. | Store at -20°C |
solubility | insoluble in H2O; ≥10.4 mg/mL in DMSO with gentle warming; ≥3.27 mg/mL in EtOH with gentle warming and ultrasonic |
form | solid |
pka | -0.51±0.20(Predicted) |
color | White to light yellow |
BTZ043 (BTZ038, BTZ044) price
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
ChemScene | CS-0019700 | BTZ043(Racemate) 98.77% | 957217-65-1 | 5mg | $90 | 2021-12-16 | Buy |
ChemScene | CS-0019700 | BTZ043(Racemate) 98.77% | 957217-65-1 | 10mg | $125 | 2021-12-16 | Buy |
ApexBio Technology | A5118 | BTZ043Racemate | 957217-65-1 | 5mg | $126 | 2021-12-16 | Buy |
ApexBio Technology | A5118 | BTZ043Racemate | 957217-65-1 | 10mg | $242 | 2021-12-16 | Buy |
ChemScene | CS-0019700 | BTZ043(Racemate) 98.77% | 957217-65-1 | 50mg | $440 | 2021-12-16 | Buy |
BTZ043 (BTZ038, BTZ044) Chemical Properties,Uses,Production
Uses
BTZ043 Racemate (BTZ10526038) is the racemate of BTZ043. BTZ043 is an inhibitor of decaprenyl-phosphoribose-epimerase (DprE1), and the antimicrobial activity of BTZ043 is more potent than BTZ043 Racemate[1].
Biological Activity
mic: 1 ng/ml (2.3 nm) for m. tuberculosis h37rv and 4 ng/ml (9.2 nm) for mycobacterium smegmatisthe loss of human lives to tuberculosis (tb) continues unabated as a result of poverty, synergy with the hiv/aids pandemic, and the emergence of multidrug- and extensively drug-resistant strains of mycobacterium tuberculosis. btz043 is the most advanced candidate for inclusion in combination therapies for both drug-sensitive and extensively drug-resistant tb.
in vitro
btz043 displayed similar activity against all clinical isolates of m. tuberculosis that were tested, including extensively drug-resistant and multidrug-resistant strains, indicating that it targets a previously unknown biological function. btz043 is bactericidal, reducing viability in vitro by more than 1000-fold in under 72 hours, which is comparable to the inh killing effect [1].
in vivo
the in vivo efficacy of btz043 was assessed 4 weeks after a low-dose aerosol infection of in the chronic balb/c mice model of tb. four weeks of treatment with btz043 reduced the bacterial load in the lungs and spleens by 1 and 2 logs, respectively, at the concentrations used. additional findings suggest that btz efficacy is time- rather than dose-dependent [1].
target
Target | Value |
DprE1 |
References
[1] makarov v, manina g, mikusova k, et al. benzothiazinones kill mycobacterium tuberculosis by blocking arabinan synthesis. science. 2009 may 8;324(5928):801-4.
BTZ043 (BTZ038, BTZ044) Preparation Products And Raw materials
Raw materials
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | laboratory@coreychem.com | China | 30230 | 58 |
InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
TargetMol Chemicals Inc. | support@targetmol.com | United States | 38669 | 58 | |
Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | masar@topule.com | China | 8467 | 58 |
Aladdin Scientific | tp@aladdinsci.com | United States | 57505 | 58 | |
BOC Sciences | 1-631-485-4226; 16314854226 | info@bocsci.com | United States | 12952 | 65 |
Dalian Meilun Biotech Co., Ltd. | 0411-62910999 13889544652 | sales@meilune.com | China | 4734 | 58 |
Shanghai Aladdin Bio-Chem Technology Co.,LTD | 400-6206333 13167063860 | anhua.mao@aladdin-e.com | China | 25003 | 65 |
AdooQ BioScience, LLC | +1 (866) 930-6790 | info@adooq.com | United States | 2782 | 58 |