Lenalidomide-propargyl-C2-amido-Ph-NH2 hydrochloride
- CAS No.
- 2748150-20-9
- Chemical Name:
- Lenalidomide-propargyl-C2-amido-Ph-NH2 hydrochloride
- Synonyms
- Lenalidomide-propargyl-C2-amido-Ph-NH2 hydrochloride;Benzamide, 4-amino-N-[5-[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1-oxo-1H-isoindol-4-yl]-4-pentyn-1-yl]-, hydrochloride (1:1)
- CBNumber:
- CB613731719
- Molecular Formula:
- C25H24N4O4.ClH
- Molecular Weight:
- 480.94
- MDL Number:
- MOL File:
- 2748150-20-9.mol
Lenalidomide-propargyl-C2-amido-Ph-NH2 hydrochloride Chemical Properties,Uses,Production
Uses
Lenalidomide-propargyl-C2-amido-Ph-NH2 hydrochloride incorporates a cereblon (CRBN) ligand for the E3 ubiquitin ligase and a linker. Lenalidomide-propargyl-C2-amido-Ph-NH2 hydrochloride can be used to design the PROTAC MD-224 (HY-114312)[1]. Lenalidomide-propargyl-C2-amido-Ph-NH2 (hydrochloride) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
IC 50
Cereblon
References
[1] Li Y, et al. Discovery of MD-224 as a First-in-Class, Highly Potent, and Efficacious Proteolysis TargetingChimera Murine Double Minute 2 Degrader Capable of Achieving Complete and Durable TumorRegression. J Med Chem. 2019 Jan 24;62(2):448-466. DOI:10.1021/acs.jmedchem.8b00909
Lenalidomide-propargyl-C2-amido-Ph-NH2 hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
Lenalidomide-propargyl-C2-amido-Ph-NH2 hydrochloride Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Jilin Province Woda Biotechnology Co., Ltd. | 13504435624 | 1927928688@qq.com | China | 1592 | 58 |
| Henan Mengtai Pharmaceutical Technology Co., Ltd | 176345344 7 17634854698 | 1959525201@qq.com | China | 8069 | 58 |
| Supplier | Advantage |
|---|---|
| Jilin Province Woda Biotechnology Co., Ltd. | 58 |
| Henan Mengtai Pharmaceutical Technology Co., Ltd | 58 |