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ChemicalBook >> CAS DataBase List >>1,6-Naphthyridin-4(1H)-one, 5-[[3-fluoro-4-[[7-(2-hydroxy-2-methylpropoxy)-4-quinolinyl]oxy]phenyl]amino]-1-methyl-3-phenyl-

1,6-Naphthyridin-4(1H)-one, 5-[[3-fluoro-4-[[7-(2-hydroxy-2-methylpropoxy)-4-quinolinyl]oxy]phenyl]amino]-1-methyl-3-phenyl-

CAS No.
2426675-70-7
Chemical Name:
1,6-Naphthyridin-4(1H)-one, 5-[[3-fluoro-4-[[7-(2-hydroxy-2-methylpropoxy)-4-quinolinyl]oxy]phenyl]amino]-1-methyl-3-phenyl-
Synonyms
c-Met-IN-12;1,6-Naphthyridin-4(1H)-one, 5-[[3-fluoro-4-[[7-(2-hydroxy-2-methylpropoxy)-4-quinolinyl]oxy]phenyl]amino]-1-methyl-3-phenyl-
CBNumber:
CB613006686
Molecular Formula:
C34H29FN4O4
Molecular Weight:
576.62
MDL Number:
MOL File:
2426675-70-7.mol
Last updated:2025-04-18 09:51:20

1,6-Naphthyridin-4(1H)-one, 5-[[3-fluoro-4-[[7-(2-hydroxy-2-methylpropoxy)-4-quinolinyl]oxy]phenyl]amino]-1-methyl-3-phenyl- Properties

Boiling point 722.8±60.0 °C(Predicted)
Density 1.335±0.06 g/cm3(Predicted)
pka 14.23±0.29(Predicted)

1,6-Naphthyridin-4(1H)-one, 5-[[3-fluoro-4-[[7-(2-hydroxy-2-methylpropoxy)-4-quinolinyl]oxy]phenyl]amino]-1-methyl-3-phenyl- Chemical Properties,Uses,Production

Uses

c-Met-IN-12 (compound 4r) is an orally active, potent and selective type II c-Met kinase inhibitor, with an IC50 of 10.6 nM. c-Met-IN-12 displays high inhibitory effects (inhibition rate > 80% in 1 μM) against AXL, Mer and TYRO3 kinases. c-Met-IN-12 can be used a scaffold for further kinase selectivity enhancement. c-Met-IN-12 shows antitumor efficacy[1].

in vivo

c-Met-IN-12 (compound 4r) (Tumor-bearing nude mice, 45 mg/kg, Orally, Q.D. for 21 days) exhibits significant tumor growth inhibition (93%) in a U-87MG human gliobastoma xenograft model[1].

References

[1] Xu H, et al. Discovery of N-substituted-3-phenyl-1,6-naphthyridinone derivatives bearing quinoline moiety as selective type II c-Met kinase inhibitors against VEGFR-2. Bioorg Med Chem. 2020 Jun 15;28(12):115555. DOI:10.1016/j.bmc.2020.115555

1,6-Naphthyridin-4(1H)-one, 5-[[3-fluoro-4-[[7-(2-hydroxy-2-methylpropoxy)-4-quinolinyl]oxy]phenyl]amino]-1-methyl-3-phenyl- Preparation Products And Raw materials

Raw materials

Preparation Products

1,6-Naphthyridin-4(1H)-one, 5-[[3-fluoro-4-[[7-(2-hydroxy-2-methylpropoxy)-4-quinolinyl]oxy]phenyl]amino]-1-methyl-3-phenyl- Suppliers

Global( 2)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc. 		+8613564774135 zijue.cai@tsbiochem.com United States 19905 58
TargetMol Chemicals Inc. 15002134094 marketing@targetmol.cn China 20032 58

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c-Met-IN-12 pictures 2025-05-01 c-Met-IN-12
2426675-70-7
 US $2500.00-1520.00 / mg 10g TargetMol Chemicals Inc.
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    2426675-70-7
  • US $2500.00-1520.00 / mg
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1,6-Naphthyridin-4(1H)-one, 5-[[3-fluoro-4-[[7-(2-hydroxy-2-methylpropoxy)-4-quinolinyl]oxy]phenyl]amino]-1-methyl-3-phenyl- c-Met-IN-12 2426675-70-7 C34H29FN4O4