ChemicalBook >> CAS DataBase List >>DM4-Sme
DM4-Sme
- CAS No.
- 796073-68-2
- Chemical Name:
- DM4-Sme
- Synonyms
- DM4-Sme;Maytansinoid DM4 Impurity 1;Maytansinoid DM4 Impurity 1-d6;Maytansine, N2'-deacetyl-N2'-[4-methyl-4-(methyldithio)-1-oxopentyl]-
- CBNumber:
- CB53959872
- Molecular Formula:
- C39H56ClN3O10S2
- Molecular Weight:
- 826.46
- MDL Number:
- MFCD28400104
- MOL File:
- 796073-68-2.mol
Last updated:2024-07-02 08:55:11
DM4-Sme price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-0104947 | DM4-SMe ≥98.0% | 796073-68-2 | 5mg | $495 | 2021-12-16 | Buy |
| ChemScene | CS-0104947 | DM4-SMe ≥98.0% | 796073-68-2 | 10mg | $750 | 2021-12-16 | Buy |
| ChemScene | CS-0104947 | DM4-SMe ≥98.0% | 796073-68-2 | 25mg | $1550 | 2021-12-16 | Buy |
| ChemScene | CS-0104947 | DM4-SMe ≥98.0% | 796073-68-2 | 50mg | $2550 | 2021-12-16 | Buy |
DM4-Sme Chemical Properties,Uses,Production
Description
DM4-SMe is a metabolite of antibody-maytansin conjugates (AMCs) and a tubulin inhibitor, and also a cytotoxic moiety of antibody-drug conjugates (ADCs), which can be linked to antibody through disulfide bond or stable thioether bond. DM4-SMe inhibits KB cells with an IC50 of 0.026 nM[1][2].
References
[1]. Widdison W, et al. Metabolites of antibody-maytansinoid conjugates: characteristics and in vitro potencies. Mol Pharm. 2015 Jun 1;12(6):1762-73. [2]. Chen H, et al. Tubulin Inhibitor-Based Antibody-Drug Conjugates for Cancer Therapy. Molecules. 2017 Aug 1;22(8).
DM4-Sme Preparation Products And Raw materials
DM4-Sme Suppliers
Global( 10)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| BOC Sciences | 16314854226; +16314854226 | inquiry@bocsci.com | United States | 19741 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32161 | 58 |
| ChemExpress | +86-021-58950125 +86-021-58950125; | info@chemexpress.com | China | 781 | 58 |
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 52924 | 58 |
| Fan De(Beijing) Biotechnology Co., Ltd. | 15911056312 | liming@bio-fount.com | China | 9729 | 58 |
| Jinan blalong chemical co. LTD | 2710913286@.com | 1513643261@qq.com | China | 14246 | 58 |
| Shanghai Haoyuan Chemexpress Co., Ltd. | 021-58950125 | info@chemexpress.com | China | 815 | 58 |
| Shanghai Zerui Biotechnology Co., Ltd. | 021-54580889 18321124657 | 731997554@qq.com | China | 10608 | 58 |
| Henan Vcommend Consultrading Co., Ltd. | 13393721940; 13393721940 | sales@vcommend.com | China | 10005 | 58 |
DM4-Sme
Maytansine, N2'-deacetyl-N2'-[4-methyl-4-(methyldithio)-1-oxopentyl]-
Maytansinoid DM4 Impurity 1
Maytansinoid DM4 Impurity 1-d6
796073-68-2