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ChemicalBook >> CAS DataBase List >>2-Chloro-5-fluoropyrimidine

2-Chloro-5-fluoropyrimidine

CAS No.
62802-42-0
Chemical Name:
2-Chloro-5-fluoropyrimidine
Synonyms
2-Chloro-5-fluoropyr;Fampridine Impurity 213;2-CHLORO-5-FLUOROPYRIMIDINE;2-Chloro-5-fluoropyriMidi...;Pyrimidine,2-chloro-5-fluoro-;2-Chloro-5-fluoro-1,3-diazine;2-Chloro-5-fluoropyrimidine >2-Chloro-5-fluoropyrimidine ,98%;Pyrimidine, 2-chloro-5-fluoro- (9CI);2-Chloro-5-fluoropyrimidine ISO 9001：2015 REACH
CBNumber:
CB5343151
Molecular Formula:
C4H2ClFN2
Molecular Weight:
132.52
MDL Number:
MFCD03788197
MOL File:
62802-42-0.mol
MSDS File:
SDS
Last updated:2024-09-09 10:26:06

2-Chloro-5-fluoropyrimidine Properties

Boiling point 149.0-162.0°C
Density 1.439 g/mL at 20 °C (lit.)
refractive index n20/D 1.503(lit.)
Flash point 150 °F
storage temp. under inert gas (nitrogen or Argon) at 2-8°C
pka -2.54±0.22(Predicted)
form Liquid
color Clear colorless to yellow
InChI InChI=1S/C4H2ClFN2/c5-4-7-1-3(6)2-8-4/h1-2H
InChIKey AGYUQBNABXVWMS-UHFFFAOYSA-N
SMILES C1(Cl)=NC=C(F)C=N1
CAS DataBase Reference 62802-42-0(CAS DataBase Reference)
FDA UNII KK43K2RZ9W

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictogramsGHS hazard pictograms
GHS05,GHS07
Signal word  Danger
Hazard statements  H302-H314
Precautionary statements  P270-P280-P301+P312-P303+P361+P353-P304+P340+P310-P305+P351+P338
Hazard Codes  Xn,Xi
Risk Statements  22-34-41-37/38
Safety Statements  26-36/37/39-45
RIDADR  UN 2735 8/PG 2
WGK Germany  3
Hazard Note  Harmful
HazardClass  IRRITANT
HazardClass  8
PackingGroup  Ⅲ
HS Code  29335990
NFPA 704
2
3 0

2-Chloro-5-fluoropyrimidine price More Price(37)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 651753 2-Chloro-5-fluoropyrimidine 97% 62802-42-0 1g $183 2023-06-20 Buy
Sigma-Aldrich 651753 2-Chloro-5-fluoropyrimidine 97% 62802-42-0 250mg $86.8 2023-01-07 Buy
TCI Chemical C2546 2-Chloro-5-fluoropyrimidine >98.0%(GC) 62802-42-0 1g $50 2024-03-01 Buy
TCI Chemical C2546 2-Chloro-5-fluoropyrimidine >98.0%(GC) 62802-42-0 5g $149 2024-03-01 Buy
Alfa Aesar H55055 2-Chloro-5-fluoropyrimidine, 97% 62802-42-0 1g $144.65 2024-03-01 Buy
Product number Packaging Price Buy
651753 1g $183 Buy
651753 250mg $86.8 Buy
C2546 1g $50 Buy
C2546 5g $149 Buy
H55055 1g $144.65 Buy

2-Chloro-5-fluoropyrimidine Chemical Properties,Uses,Production

Chemical Properties

Colorless to light yellow liquid

Uses

2-Chloro-5-fluoropyrimidine is used to prepare 2,4-disubstituted-5-fluoropyrimidine , which is a biologically active molecule seen in anticancer agents like 5-fluorouracil.

Uses

2-Chloro-5-fluoropyrimidine can be used as a starting material for the preparation of:
5-fluoro-2-amino pyrimidines by reacting with various amines in the presence of K2CO3, via C-N bond forming reaction.
2-chloro-5-(5-fluoropyrimidin-2-yl)benzoic acid, an intermediate, which is used in the synthesis of benzamide scaffolds as potent antagonists against P2X7 receptors.
5-fluoro-2-cyano pyrimidine, a key intermediate used for the synthesis of 5-chloro-N-[(1S)-1-(5-fluoropyrimidin-2-yl)ethyl]-N-(5-methyl-1H-pyrazol-3-yl)pyrimidine-2,4-diamine, as a potent inhibitor of the JAK2 kinase.

Preparation

Synthesis of 2-chloro-5-fluoropyrimidine: add 2,4-Dichloro-5-fluoropyrimidine and reducing metal powder to the solvent, stir to raise the temperature to the reaction temperature, slowly add acid dropwise, and keep the temperature until the reaction is completed Finish. Filtration, phase separation or direct evaporation of the solvent, and distillation under reduced pressure to remove the solvent to obtain 2-chloro-5-fluoropyrimidine.

References

[1] A. Dunaiskis. “LARGE SCALE SYNTHESIS OF 2-CHLORO-5-FLUOROPYRIMIDINE.” Organic Preparations and Procedures International 27 1 (1995): 600–602.
[2] A. DUNAISKIS. “ChemInform Abstract: Large Scale Synthesis of 2-Chloro-5-fluoropyrimidine.” ChemInform 26 52 (1995).

2927-71-1
62802-42-0
Synthesis of 2-Chloro-5-fluoropyrimidine from 2,4-Dichloro-5-fluoropyrimidine

2-Chloro-5-fluoropyrimidine Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 373)Suppliers
Supplier Tel Email Country ProdList Advantage
Win-Win chemical CO., Limited 		+86-0086-577-64498589 +86-15355981851 sales@win-winchemical.com China 14426 58
Henan Fengda Chemical Co., Ltd 		+86-371-86557731 +86-13613820652 info@fdachem.com China 20284 58
Capot Chemical Co.,Ltd. 		+86-（0）57185586718 +86-13336195806 sales@capot.com China 29791 60
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21634 55
Hangzhou FandaChem Co.,Ltd. 		+8615858145714 FandaChem@Gmail.com China 9095 55
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 32957 60
career henan chemical co 		+86-0371-86658258 +8613203830695 sales@coreychem.com China 29880 58
Zhejiang ZETian Fine Chemicals Co. LTD 		+8618957127338 stella@zetchem.com China 2136 58
Shanghai Arbor Chemical Co., Ltd. 		021-60451682 act@arborchemical.com CHINA 904 58
Win-Win Chemical CO., Limited 		0086-577-64498589 sales@win-winchemical.com CHINA 998 58

View Lastest Price from 2-Chloro-5-fluoropyrimidine manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
2-Chloro-5-fluoropyrimidine pictures 2024-12-13 2-Chloro-5-fluoropyrimidine
62802-42-0
 US $0.00 / KG 1KG 98%min 30tons/month WUHAN FORTUNA CHEMICAL CO., LTD
2-Chloro-5-fluoropyrimidine pictures 2024-04-18 2-Chloro-5-fluoropyrimidine
62802-42-0
 US $35.00-1.20 / kg 1kg 99% g-kg-tons, free sample is available Henan Fengda Chemical Co., Ltd
2-Chloro-5-fluoropyrimidine pictures 2024-04-17 2-Chloro-5-fluoropyrimidine
62802-42-0
 US $1.10 / g 1g 99.0% min 100 tons min Shaanxi Dideu Medichem Co. Ltd

2-Chloro-5-fluoropyrimidine Spectrum

Pyrimidine, 2-chloro-5-fluoro- (9CI) 2-CHLORO-5-FLUOROPYRIMIDINE Pyrimidine,2-chloro-5-fluoro- 2-Chloro-5-fluoropyr 2-Chloro-5-fluoropyriMidi... 2-Chloro-5-fluoropyrimidine ,98% 2-Chloro-5-fluoro-1,3-diazine 2-Chloro-5-fluoropyrimidine > 2-Chloro-5-fluoropyrimidine ISO 9001：2015 REACH Fampridine Impurity 213 62802-42-0 63802-42-0 C4H2ClFN2 Building Blocks Heterocyclic Building Blocks Halogenated Heterocycles Pyrimidines Halogenated Heterocycles Heterocyclic Building Blocks PyrimidinesHeterocyclic Building Blocks Variety of halogenated heterocyclic series PYRIMIDINE Pyrimidine series pharmacetical Pyrimidines Fluorine series Bases & Related Reagents Nucleotides Building Blocks 62802-42-0