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ChemicalBook >> CAS DataBase List >>1-((3R,4R)-3-(((5-chloro-2-((1-methyl-1H-pyrazol-4-yl)amino)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)oxy)methyl)-4-methoxypyrrolidin-1-yl)prop-2-en-1-one

1-((3R,4R)-3-(((5-chloro-2-((1-methyl-1H-pyrazol-4-yl)amino)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)oxy)methyl)-4-methoxypyrrolidin-1-yl)prop-2-en-1-one

CAS No.
1428774-45-1
Chemical Name:
1-((3R,4R)-3-(((5-chloro-2-((1-methyl-1H-pyrazol-4-yl)amino)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)oxy)methyl)-4-methoxypyrrolidin-1-yl)prop-2-en-1-one
Synonyms
EOS-61635;PF-06459988;PF-06459988 >=98% (HPLC);1-((3R,4R)-3-(((5-chloro-1H-pyrazol-4-yl)amino)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)oxy)methyl)-4-methoxypyrrolidin-1-yl)prop-2-en-1-one;irreversible,oral,T790M,Inhibitor,EGFR,PF 06459988,PF-06459988,HER1,NSCLC,inhibit,PF06459988,Epidermal growth factor receptor,cancer,ErbB-1;1-((3R,4R)-3-(((5-chloro-2-((1-methyl-1H-pyrazol-4-yl)amino)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)oxy)methyl)-4-methoxypyrrolidin-1-yl)prop-2-en-1-one;2-Propen-1-one, 1-[(3R,4R)-3-[[[5-chloro-2-[(1-methyl-1H-pyrazol-4-yl)amino]-7H-pyrrolo[2,3-d]pyrimidin-4-yl]oxy]methyl]-4-methoxy-1-pyrrolidinyl]-
CBNumber:
CB53133463
Molecular Formula:
C19H22ClN7O3
Molecular Weight:
431.88
MDL Number:
MFCD28987462
MOL File:
1428774-45-1.mol
Last updated:2025-04-30 21:36:36

1-((3R,4R)-3-(((5-chloro-2-((1-methyl-1H-pyrazol-4-yl)amino)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)oxy)methyl)-4-methoxypyrrolidin-1-yl)prop-2-en-1-one Properties

Density 1.50±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMSO : 50 mg/mL (115.77 mM)
form Solid
pka 11.26±0.50(Predicted)
color White to off-white
FDA UNII 5IE92SK9EB
UNSPSC Code 12352200
NACRES NA.77

1-((3R,4R)-3-(((5-chloro-2-((1-methyl-1H-pyrazol-4-yl)amino)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)oxy)methyl)-4-methoxypyrrolidin-1-yl)prop-2-en-1-one price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
ChemScene CS-0017709 PF-06459988 99.49% 1428774-45-1 5mg $80 2021-12-16 Buy
ChemScene CS-0017709 PF-06459988 99.49% 1428774-45-1 10mg $140 2021-12-16 Buy
ChemScene CS-0017709 PF-06459988 99.49% 1428774-45-1 25mg $290 2021-12-16 Buy
ChemScene CS-0017709 PF-06459988 99.49% 1428774-45-1 50mg $520 2021-12-16 Buy
ChemScene CS-0017709 PF-06459988 99.49% 1428774-45-1 100mg $920 2021-12-16 Buy
Product number Packaging Price Buy
CS-0017709 5mg $80 Buy
CS-0017709 10mg $140 Buy
CS-0017709 25mg $290 Buy
CS-0017709 50mg $520 Buy
CS-0017709 100mg $920 Buy

1-((3R,4R)-3-(((5-chloro-2-((1-methyl-1H-pyrazol-4-yl)amino)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)oxy)methyl)-4-methoxypyrrolidin-1-yl)prop-2-en-1-one Chemical Properties,Uses,Production

Uses

PF-06459988 is an orally activity, irreversible and mutant-selective inhibitor of EGFR mutant forms. PF-06459988 demonstrates high potency and specificity to the T790M-containing double mutant EGFRs. PF-06459988 can be used for the research of cancer[1].

Biological Activity

PF-06459988 is an orally available irreversible inhibitor of epidermal growth factor receptor (EGFR) mutant (EGFRm) forms including the secondary acquired resistance mutation T790M. PF-06459988 has minimal activity against wild-type EGFR (WT EGFR).

References

[1] Cheng H, et al. Discovery of 1-{(3R,4R)-3-[({5-Chloro-2-[(1-methyl-1H-pyrazol-4-yl)amino]-7H-pyrrolo[2,3-d]pyrimidin-4-yl}oxy)methyl]-4-methoxypyrrolidin-1-yl}prop-2-en-1-one (PF-06459988), a Potent, WT Sparing, Irreversible Inhibitor of T790M-Containing EGFR Mutants. J Med Chem. 2016 Mar 10;59(5):2005-24. doi: 10.1021/acs.jmedchem.5b01633. Epub 2016 Jan 28. DOI:10.1021/acs.jmedchem.5b01633

1-((3R,4R)-3-(((5-chloro-2-((1-methyl-1H-pyrazol-4-yl)amino)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)oxy)methyl)-4-methoxypyrrolidin-1-yl)prop-2-en-1-one Preparation Products And Raw materials

Raw materials

Preparation Products

1-((3R,4R)-3-(((5-chloro-2-((1-methyl-1H-pyrazol-4-yl)amino)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)oxy)methyl)-4-methoxypyrrolidin-1-yl)prop-2-en-1-one Suppliers

Global( 33)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32275 58
Career Henan Chemica Co 		+86-0371-86658258 +8613203830695 laboratory@coreychem.com China 30230 58
HANGZHOU CLAP TECHNOLOGY CO.,LTD 		86-571-88216897,88216896 13588875226 sales@hzclap.com CHINA 6312 58
InvivoChem 		+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6391 58
Amadis Chemical Company Limited 		571-89925085 sales@amadischem.com China 131957 58
Jinan elephant international trading co., LTD 13006575422@163.com China 6355 58
Beijing Solarbio Science & Tecnology Co., Ltd. 010-50973130 17801761073 3193328036@qq.com China 29763 68
Zhongshan Geometric Biological Technology Co., Ltd. +86-13168912896 China 253 58
Kaixin Chemical (Hong Kong) Limited 010-88886666-01 13112345678 loyson@tcypharm.com China 596 55
Shanghai Biopharmaleader Co., Ltd. +86 18721201413 sales@biopharmaleader.com China 1720 58

View Lastest Price from 1-((3R,4R)-3-(((5-chloro-2-((1-methyl-1H-pyrazol-4-yl)amino)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)oxy)methyl)-4-methoxypyrrolidin-1-yl)prop-2-en-1-one manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
PF-06459988 pictures 2025-04-30 PF-06459988
1428774-45-1
 US $149.00 / mg 98% 10g TargetMol Chemicals Inc.
  • PF-06459988 pictures
  • PF-06459988
    1428774-45-1
  • US $149.00 / mg
  • 98%
  • TargetMol Chemicals Inc.
1-((3R,4R)-3-(((5-chloro-2-((1-methyl-1H-pyrazol-4-yl)amino)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)oxy)methyl)-4-methoxypyrrolidin-1-yl)prop-2-en-1-one PF-06459988 PF-06459988 >=98% (HPLC) 2-Propen-1-one, 1-[(3R,4R)-3-[[[5-chloro-2-[(1-methyl-1H-pyrazol-4-yl)amino]-7H-pyrrolo[2,3-d]pyrimidin-4-yl]oxy]methyl]-4-methoxy-1-pyrrolidinyl]- 1-((3R,4R)-3-(((5-chloro-1H-pyrazol-4-yl)amino)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)oxy)methyl)-4-methoxypyrrolidin-1-yl)prop-2-en-1-one EOS-61635 irreversible,oral,T790M,Inhibitor,EGFR,PF 06459988,PF-06459988,HER1,NSCLC,inhibit,PF06459988,Epidermal growth factor receptor,cancer,ErbB-1 1428774-45-1