AlviMopan (Monohydrate)
- CAS No.
- 1383577-62-5
- Chemical Name:
- AlviMopan (Monohydrate)
- Synonyms
- AlviMopan (Monohydrate);((S)-2-benzyl-3-((3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethylpiperidin-1-yl)propanoyl)glycine hydrate;N-[(2S)-2-[[(3R,4R)-4-(3-Hydroxyphenyl)-3,4-dimethyl-1-piperidinyl]methyl]-1-oxo-3-phenylpropyl]glycine hydrate (1:1)
- CBNumber:
- CB52666584
- Molecular Formula:
- C25H34N2O5
- Molecular Weight:
- 442.56
- MDL Number:
- MOL File:
- 1383577-62-5.mol
- MSDS File:
- SDS
| storage temp. | Store at -20°C |
|---|---|
| solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. |
| form | Powder |
| color | White to off-white |
| FDA UNII | 28LAR2REDG |
AlviMopan (Monohydrate) price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-1539 | Alvimopan(monohydrate) 99.18% | 1383577-62-5 | 2mg | $80 | 2021-12-16 | Buy |
| CSNpharm | CSN17774 | AlvimopanMonohydrate | 1383577-62-5 | 10mg | $140 | 2021-12-16 | Buy |
| CSNpharm | CSN17774 | AlvimopanMonohydrate | 1383577-62-5 | 25mg | $265 | 2021-12-16 | Buy |
| Crysdot | CD31003675 | Alvimopanmonohydrate 98+% | 1383577-62-5 | 5mg | $320 | 2021-12-16 | Buy |
| Crysdot | CD31003675 | Alvimopanmonohydrate 98+% | 1383577-62-5 | 10mg | $440 | 2021-12-16 | Buy |
AlviMopan (Monohydrate) Chemical Properties,Uses,Production
Uses
Alvimopan monohydrate (ADL 8-2698 monohydrate) is a potent, selective, orally active and reversible μ-opioid receptor antagonist, with an IC50 of 1.7 nM. Alvimopan monohydrate has selectivity for μ-opioid receptor (Ki=0.47 nM) over κ- and δ-opioid receptors (Kis=100, 12 nM, respectively). Alvimopan monohydrate can be used for the research of postoperative ileus[1][2][3].
in vivo
Alvimopan (0.1-1.0 mg/kg; p.o.) partially antagonizes the slowing of small intestinal transit of 113Sn-labelled microspheres in rats[3].
Alvimopan (3 mg/kg; p.o.) has no effect on the visceromotor behavioural responses (VMR) induced by noxious colorectal distension (CRD) in conscious rats[3].
IC 50
μ Opioid Receptor/MOR
References
[1] Bourdonnec BL, et, al. Novel trans-3,4-dimethyl-4-(3-hydroxyphenyl)piperidines as mu opioid receptor antagonists with improved opioid receptor selectivity profiles. Bioorg Med Chem Lett. 2008 Mar 15;18(6):2006-12. DOI:10.1016/j.bmcl.2008.01.106
[2] Erowele GI, et, al. Alvimopan (Entereg), a Peripherally Acting mu-Opioid Receptor Antagonist For Postoperative Ileus. P T. 2008 Oct;33(10):574-83. PMID:19750041
[3] Meerveld BG, et, al. Preclinical studies of opioids and opioid antagonists on gastrointestinal function. Neurogastroenterol Motil. 2004 Oct;16 Suppl 2:46-53. DOI:10.1111/j.1743-3150.2004.00555.x
AlviMopan (Monohydrate) Preparation Products And Raw materials
Raw materials
Preparation Products
AlviMopan (Monohydrate) Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +17819995354 | marketing@targetmol.com | United States | 32284 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6312 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
| TargetMol Chemicals Inc. | support@targetmol.com | United States | 38668 | 58 | |
| TargetMol Chemicals Inc. | +17819995354 | marketing@targetmol.com | United States | 19904 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131957 | 58 |
| BOC Sciences | 1-631-485-4226; 16314854226 | info@bocsci.com | United States | 12952 | 65 |
| Haoyuan Chemexpress Co., Ltd. | 021-58950125 | info@chemexpress.com | China | 7552 | 61 |
| MedChemexpress LLC | 021-58955995 | sales@medchemexpress.cn | United States | 4861 | 58 |
| AdooQ BioScience, LLC | +1 (866) 930-6790 | info@adooq.com | United States | 2782 | 58 |
| Supplier | Advantage |
|---|---|
| TargetMol Chemicals Inc. | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 58 |
| InvivoChem | 58 |
| TargetMol Chemicals Inc. | 58 |
| TargetMol Chemicals Inc. | 58 |
| Amadis Chemical Company Limited | 58 |
| BOC Sciences | 65 |
| Haoyuan Chemexpress Co., Ltd. | 61 |
| MedChemexpress LLC | 58 |
| AdooQ BioScience, LLC | 58 |
View Lastest Price from AlviMopan (Monohydrate) manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-10-28 | Alvimopan monohydrate
1383577-62-5
|
US $0.00-0.00 / mg | 10g | TargetMol Chemicals Inc. |
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- Alvimopan monohydrate
1383577-62-5
- US $0.00-0.00 / mg
- TargetMol Chemicals Inc.