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ChemicalBook >> CAS DataBase List >>CAY10595

CAY10595

CAS No.
916047-16-0
Chemical Name:
CAY10595
Synonyms
CAY10595;CAY10595,CAY-10595;CAY10595 Exclusive;IXKFWNVFUXXEFY-UHFFFAOYSA-N;Spiro[3H-indole-3,3'-pyrrolidine]-1(2H)-acetic acid, 5-chloro-1'-[(5-chloro-2-fluorophenyl)methyl]-2,2',5'-trioxo-
CBNumber:
CB52590436
Molecular Formula:
C20H13Cl2FN2O5
Molecular Weight:
451.23
MDL Number:
MFCD18427989
MOL File:
916047-16-0.mol
Last updated:2024-11-19 20:33:22

CAY10595 Properties

storage temp. Store at -20°C
solubility DMF: 30 mg/ml; DMSO: 30 mg/ml; DMSO:PBS (pH 7.2) (1:10): 0.5 mg/ml; Ethanol: 25 mg/ml
form A crystalline solid

CAY10595 price More Price(4)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 10012553 CAY10595 ≥97% 916047-16-0 1mg $66 2024-03-01 Buy
Cayman Chemical 10012553 CAY10595 ≥97% 916047-16-0 5mg $291 2024-03-01 Buy
Cayman Chemical 10012553 CAY10595 ≥97% 916047-16-0 10mg $516 2024-03-01 Buy
AK Scientific 1879CW 2-[5-Chloro-1'-[(5-chloro-2-fluorophenyl)methyl]-2,2',5'-trioxospiro[indole-3,3'-pyrrolidine]-1-yl]aceticacid 916047-16-0 10mg $672 2021-12-16 Buy
Product number Packaging Price Buy
10012553 1mg $66 Buy
10012553 5mg $291 Buy
10012553 10mg $516 Buy
1879CW 10mg $672 Buy

CAY10595 Chemical Properties,Uses,Production

Description

The biological effects of prostaglandin D2 (PGD2) are transduced by at least two 7-transmembrane G protein-coupled receptors, designated DP1 and CRTH2/DP2. In humans, CRTH2/DP2 is expressed on Th2 cells, eosinophils, and basophils where it mediates the chemotactic activity of PGD2.1 CAY10595, as a racemic mixture, is a potent CRTH2/DP2 receptor antagonist that binds to the human receptor with a Ki value of 10 nM.2 The R enantiomer of CAY10595 is significantly more potent exhibiting Ki values of 5.3 and 5 nM at the human and murine CRTH2/DP2 receptor, respectively. The R enantiomer of CAY10595 inhibits eosinophil chemotaxis induced by 13,14-dihydro-15-keto-PGD2 with an IC50 value of 7.3 nM.2

References

1. Hirai, H., Tanaka, K., Yoshie, O., et al. Prostaglandin D2 selectivity induces chemotaxis in T helper type 2 cells, eosinophils, and basophils via seven-transmembrane receptor CRTH2 J. Exp. Med. 193(2),255-261(2001).
2. Crosignani, S., Page, P., Missotten, M., et al. Discovery of a new class of potent, selective, and orally bioavailable CRTH2 (DP2) receptor antagonists for the treatment of allergic inflammatory diseases J. Med. Chem. 51,2227-2243(2008).

CAY10595 Preparation Products And Raw materials

Raw materials

Preparation Products

CAY10595 Suppliers

Global( 28)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32161 58
TargetMol Chemicals Inc. 		support@targetmol.com United States 38631 58
Aladdin Scientific 		+1-+1(833)-552-7181 sales@aladdinsci.com United States 57505 58
Shanghai Aladdin Bio-Chem Technology Co.,LTD 400-400-6206333 18521732826 market@aladdin-e.com China 25003 65
Shanghai EFE Biological Technology Co., Ltd. 021-65675885 18964387627 info@efebio.com China 9806 58
Chongqing Chemieliva Pharmaceutical Co., Ltd. 023-67770219 jessica.hu@chemieliva.com China 1450 60
Fan De(Beijing) Biotechnology Co., Ltd. 15911056312 liming@bio-fount.com China 9729 58
Hangzhou Synstar pharmaceutical Technology CO.,Ltd 0571-85361029 synstar518@163.com China 1990 58
DC Chemicals 021-58447131 13564518121 sales@dcchemicals.com China 9409 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 18818260767 sales@chemegen.com China 11218 58

View Lastest Price from CAY10595 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
CAY10595 pictures 2024-11-19 CAY10595
916047-16-0
 US $46.00-349.00 / mg 99.71% 10g TargetMol Chemicals Inc.
CAY10595 pictures 2024-11-19 CAY10595
916047-16-0
 US $46.00-349.00 / mg 99.71% 10g TargetMol Chemicals Inc.
  • CAY10595 pictures
  • CAY10595
    916047-16-0
  • US $46.00-349.00 / mg
  • 99.71%
  • TargetMol Chemicals Inc.
  • CAY10595 pictures
  • CAY10595
    916047-16-0
  • US $46.00-349.00 / mg
  • 99.71%
  • TargetMol Chemicals Inc.

CAY10595 Spectrum

CAY10595 CAY10595 Exclusive IXKFWNVFUXXEFY-UHFFFAOYSA-N Spiro[3H-indole-3,3'-pyrrolidine]-1(2H)-acetic acid, 5-chloro-1'-[(5-chloro-2-fluorophenyl)methyl]-2,2',5'-trioxo- CAY10595,CAY-10595 916047-16-0