2,4-Quinazolinediamine, N4-cyclohexyl-N2-(3,4-difluorophenyl)-
- CAS No.
- 911678-60-9
- Chemical Name:
- 2,4-Quinazolinediamine, N4-cyclohexyl-N2-(3,4-difluorophenyl)-
- Synonyms
- DFPQ;2,4-Quinazolinediamine, N4-cyclohexyl-N2-(3,4-difluorophenyl)-
- CBNumber:
- CB514172611
- Molecular Formula:
- C20H20F2N4
- Molecular Weight:
- 354.4
- MDL Number:
- MOL File:
- 911678-60-9.mol
| Boiling point | 531.6±60.0 °C(predicted) |
|---|---|
| Density | 1.330±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted) |
| storage temp. | 2-8°C |
| solubility | DMSO: 2mg/mL, clear |
| form | powder |
| pka | 7.38±0.30(predicted) |
| color | white to beige |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
2,4-Quinazolinediamine, N4-cyclohexyl-N2-(3,4-difluorophenyl)- Chemical Properties,Uses,Production
Biological Activity
Gs-biased, β2 subtype-selective adrenergic receptor (AR) negative allosteric modulator (NAM) th at inhibits β-arrestin recruitment, but not Gs coupling to β2AR.
DFPQ is a Gs-biased, β2 subtype-selective adrenergic receptor (AR) negative allosteric modulator (NAM) th at inhibits β-arrestin recruitment (IC50 = 600 nM; 30-min DFPQ pretreatment prior to 12-min 1 μM ISO induction), but not Gs coupling to β2AR (30-min 10 μM DFPQ pretreatment prior to 10-min 1 μM ISO-induced cAMP production). DFPQ effectively inhibits agonist-induced β2AR phosphorylation (IC50 = 2.6 μM; 30-min DFPQ pretreatment prior to 10-min 1 μM ISO induction) and internalization (100% inhibition by 30-min 10 μM DFPQ prior to 1h 10 μM ISO) and protects against the functional desensitization of β-agonist-mediated regulation in cell and tissue models with minimal effects on β1AR.
2,4-Quinazolinediamine, N4-cyclohexyl-N2-(3,4-difluorophenyl)- Preparation Products And Raw materials
Raw materials
Preparation Products
2,4-Quinazolinediamine, N4-cyclohexyl-N2-(3,4-difluorophenyl)- Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 11973 | 58 |
| Merck KGaA | 21-20338288 | ordercn@merckgroup.com | China | 292394 | 58 |
| Supplier | Advantage |
|---|---|
| Shanghai Yifei Biotechnology Co. , Ltd. | 58 |
| Merck KGaA | 58 |