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ChemicalBook >> CAS DataBase List >>2-Pyridinecarboxamide, N-(2-aminophenyl)-5-[[2-(2-naphthalenyl)acetyl]amino]-

2-Pyridinecarboxamide, N-(2-aminophenyl)-5-[[2-(2-naphthalenyl)acetyl]amino]-

CAS No.
2075787-77-6
Chemical Name:
2-Pyridinecarboxamide, N-(2-aminophenyl)-5-[[2-(2-naphthalenyl)acetyl]amino]-
Synonyms
MC2664;HDAC-IN-52;HDAC-IN-52, 10 mM in DMSO;N-(2-Aminophenyl)-5-(2-(naphthalen-2-yl)acetamido)picolinamide;2-Pyridinecarboxamide, N-(2-aminophenyl)-5-[[2-(2-naphthalenyl)acetyl]amino]-
CBNumber:
CB513145931
Molecular Formula:
C24H20N4O2
Molecular Weight:
396.44
MDL Number:
MOL File:
2075787-77-6.mol
Last updated:2025-04-18 09:52:24

2-Pyridinecarboxamide, N-(2-aminophenyl)-5-[[2-(2-naphthalenyl)acetyl]amino]- Properties

Boiling point 632.7±55.0 °C(Predicted)
Density 1.359±0.06 g/cm3(Predicted)
pka 11.12±0.70(Predicted)
form Solid
color Off-white to light yellow

2-Pyridinecarboxamide, N-(2-aminophenyl)-5-[[2-(2-naphthalenyl)acetyl]amino]- Chemical Properties,Uses,Production

Uses

HDAC-IN-52 is a pyridine-containing HDAC inhibitor, with IC50s of 0.189, 0.227, 0.440 and 0.446 μM for HDAC1, HDAC2, HDAC3, and HDAC10, respectively. HDAC-IN-52 can be used for the research of cancer[1].

IC 50

hHDAC1: 0.189 μM (IC50); hHDAC2: 0.227 μM (IC50); hHDAC3: 0.440 μM (IC50); hHDAC10: 0.446 μM (IC50)

References

[1] Bello ED, et, al. Novel pyridine-containing histone deacetylase inhibitors strongly arrest proliferation, induce apoptosis and modulate miRNAs in cancer cells. Eur J Med Chem. 2022 Dec 15;247:115022. DOI:10.1016/j.ejmech.2022.115022

2-Pyridinecarboxamide, N-(2-aminophenyl)-5-[[2-(2-naphthalenyl)acetyl]amino]- Preparation Products And Raw materials

Raw materials

Preparation Products

2-Pyridinecarboxamide, N-(2-aminophenyl)-5-[[2-(2-naphthalenyl)acetyl]amino]- Suppliers

Global( 12)Suppliers
Supplier Tel Email Country ProdList Advantage
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 33024 60
Shanghai Beckham Medical Technology Co., Ltd 021-13816613772 13816613772 huahero21@sina.com China 997 55
Shanghai Chaolan Chemical Technology Center 021-QQ：65489617 15618227136 Sales@ATKchemical.com China 9348 58
Wuxi Donghe Pharmaceutical Technology Co., Ltd. 63313187 15358055255 63313187@qq.com China 1988 58
Hubei wei shi reagent group ltd., company 027-59102966 18717199209 2853877583@qq.com China 2993 58
Bide Pharmatech Ltd. 400-1647117 13681763483 product02@bidepharm.com China 62321 58
TargetMol Chemicals Inc. 4008200310 marketing@tsbiochem.com China 24875 58
Shanghai Yifei Biotechnology Co. , Ltd. 021-65675885 18964387627 customer_service@efebio.com China 11973 58
nanjing 13376082704 13376082704 3930959291@qq.com China 2905 58
Sangon Biotech (Shanghai) Co.,Ltd. 400-821-026 Sales@sangon.com China 55710 58
2-Pyridinecarboxamide, N-(2-aminophenyl)-5-[[2-(2-naphthalenyl)acetyl]amino]- MC2664 HDAC-IN-52 N-(2-Aminophenyl)-5-(2-(naphthalen-2-yl)acetamido)picolinamide HDAC-IN-52, 10 mM in DMSO 2075787-77-6