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ChemicalBook >> CAS DataBase List >>4H-1-Benzopyran-4-one, 2-(1H-1,2,4-triazol-1-yl)-3-[4-(trifluoromethyl)phenyl]-

4H-1-Benzopyran-4-one, 2-(1H-1,2,4-triazol-1-yl)-3-[4-(trifluoromethyl)phenyl]-

CAS No.
1639929-29-5
Chemical Name:
4H-1-Benzopyran-4-one, 2-(1H-1,2,4-triazol-1-yl)-3-[4-(trifluoromethyl)phenyl]-
Synonyms
Chromenone 1;Chromenone 1, 10 mM in DMSO;2-(1H-1,2,4-Triazol-1-yl)-3-(4-(trifluoromethyl)phenyl)-4H-chromen-4-one;4H-1-Benzopyran-4-one, 2-(1H-1,2,4-triazol-1-yl)-3-[4-(trifluoromethyl)phenyl]-
CBNumber:
CB512625511
Molecular Formula:
C18H10F3N3O2
Molecular Weight:
357.29
MDL Number:
MOL File:
1639929-29-5.mol
Last updated:2025-05-12 19:02:03

4H-1-Benzopyran-4-one, 2-(1H-1,2,4-triazol-1-yl)-3-[4-(trifluoromethyl)phenyl]- Properties

Boiling point 474.2±55.0 °C(Predicted)
Density 1.45±0.1 g/cm3(Predicted)
storage temp. 2-8°C
solubility DMSO: 2mg/mL, clear
form Solid
pka 3.14±0.19(Predicted)
color Light yellow to yellow
UNSPSC Code 12352200
NACRES NA.77

4H-1-Benzopyran-4-one, 2-(1H-1,2,4-triazol-1-yl)-3-[4-(trifluoromethyl)phenyl]- Chemical Properties,Uses,Production

Uses

Chromenone 1 is a potent osteogenic bone morphogenetic protein (BMP) potentiator. Chromenone 1 exhibits a unique mode of action as it induces a pronounced, kinase-independent, negative TGFβ feedback that enhances nuclear BMP-Smad signaling outputs[1].

Biological Activity

Chromenone 1 is a bone morphogenetic protein (BMP) signaling potentiator th at exerts its effect via negative TGFβ feedback loops, independent of direct kinase inhibition. Chromenone 1 prevents cardiogenesis induction by 0.5 μM BMP inhibitor DMH1 (IC50 = 200 nM; mESC-Myh6-GFP) and efficiently stimulates BMP-dependent osteogenesis from C2C12 myoblasts (ALP activity induction EC50 = 340 nM; E100% and Emax = induction by 7.5 and 50 ng/mL BMP-4, respectively).

References

[1] Wesseler F, et al. Probing Embryonic Development Enables the Discovery of Unique Small-Molecule Bone Morphogenetic Protein Potentiators. J Med Chem. 2022;65(5):3978-3990. DOI:10.1021/acs.jmedchem.1c01800

4H-1-Benzopyran-4-one, 2-(1H-1,2,4-triazol-1-yl)-3-[4-(trifluoromethyl)phenyl]- Preparation Products And Raw materials

Raw materials

Preparation Products

4H-1-Benzopyran-4-one, 2-(1H-1,2,4-triazol-1-yl)-3-[4-(trifluoromethyl)phenyl]- Suppliers

Global( 9)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc. 		+17819995354 marketing@targetmol.com United States 32285 58
MQ (shanghai) Pharmaceuticals Co., Ltd. 13761635123 1014988033@qq.com China 4951 55
Bide Pharmatech Ltd. 400-1647117 13681763483 product02@bidepharm.com China 62321 58
Shanghai Yifei Biotechnology Co. , Ltd. 021-65675885 18964387627 customer_service@efebio.com China 11973 58
TargetMol Chemicals Inc. 15002134094 marketing@targetmol.cn China 21356 58
Sangon Biotech (Shanghai) Co.,Ltd. 400-821-026 Sales@sangon.com China 6710 58
Merck KGaA 21-20338288 ordercn@merckgroup.com China 6394 58

View Lastest Price from 4H-1-Benzopyran-4-one, 2-(1H-1,2,4-triazol-1-yl)-3-[4-(trifluoromethyl)phenyl]- manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Chromenone 1 pictures 2025-05-12 Chromenone 1
1639929-29-5
 US $70.00-236.00 / mg 100% 10g TargetMol Chemicals Inc.
  • Chromenone 1 pictures
  • Chromenone 1
    1639929-29-5
  • US $70.00-236.00 / mg
  • 100%
  • TargetMol Chemicals Inc.

4H-1-Benzopyran-4-one, 2-(1H-1,2,4-triazol-1-yl)-3-[4-(trifluoromethyl)phenyl]- Spectrum

4H-1-Benzopyran-4-one, 2-(1H-1,2,4-triazol-1-yl)-3-[4-(trifluoromethyl)phenyl]- Chromenone 1 2-(1H-1,2,4-Triazol-1-yl)-3-(4-(trifluoromethyl)phenyl)-4H-chromen-4-one Chromenone 1, 10 mM in DMSO 1639929-29-5