ChemicalBook >> CAS DataBase List >>4-[7-(1-adamantyl)-6-(2-methoxyethoxymethoxy)naphthalen-2-yl]benzoic a cid
4-[7-(1-adamantyl)-6-(2-methoxyethoxymethoxy)naphthalen-2-yl]benzoic a cid
![4-[7-(1-adamantyl)-6-(2-methoxyethoxymethoxy)naphthalen-2-yl]benzoic a cid Structure](CAS/GIF/170355-78-9.gif)
- CAS No.
- 170355-78-9
- Chemical Name:
- 4-[7-(1-adamantyl)-6-(2-methoxyethoxymethoxy)naphthalen-2-yl]benzoic a cid
- Synonyms
- CD 2665;CD2665,CD-2665;CD2665, 10 mM in DMSO;4-[7-(1-ADAMANTYL)-6-(2-METHOXYETHOXYMETHOXY)NAPHTHALEN-3-YL]BENZOIC ACID;4-[7-(1-adamantyl)-6-(2-methoxyethoxymethoxy)naphthalen-2-yl]benzoic a cid;4-[6-[(2-Methoxyethoxy)methoxy]-7-tricyclo[3.3.1.13,7]dec-1-yl-2-naphthalenyl)benzoicacid;4-(7-((3r,5r,7r)-adamantan-1-yl)-6-((2-methoxyethoxy)methoxy)naphthalen-2-yl)benzoic acid;Benzoic acid, 4-[6-[(2-methoxyethoxy)methoxy]-7-tricyclo[3.3.1.13,7]dec-1-yl-2-naphthalenyl]-
- CBNumber:
- CB51257976
- Molecular Formula:
- C31H34O5
- Molecular Weight:
- 486.6
- MDL Number:
- MFCD13176719
- MOL File:
- 170355-78-9.mol
Last updated:2025-04-17 18:22:24
| Boiling point | 668.6±55.0 °C(Predicted) |
|---|---|
| Density | 1.227±0.06 g/cm3(Predicted) |
| storage temp. | Store at +4°C |
| solubility | DMF: 30 mg/ml; DMF:PBS (pH 7.2) (1:1): 0.5 mg/ml; DMSO: 25 mg/ml |
| form | A crystalline solid |
| pka | 4.13±0.10(Predicted) |
| color | White to off-white |
4-[7-(1-adamantyl)-6-(2-methoxyethoxymethoxy)naphthalen-2-yl]benzoic a cid price More Price(14)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 16031 | CD2665 ≥98% | 170355-78-9 | 1mg | $37 | 2024-03-01 | Buy |
| Cayman Chemical | 16031 | CD2665 ≥98% | 170355-78-9 | 5mg | $116 | 2024-03-01 | Buy |
| Cayman Chemical | 16031 | CD2665 ≥98% | 170355-78-9 | 10mg | $213 | 2024-03-01 | Buy |
| Tocris | 3800 | CD2665 ≥98%(HPLC) | 170355-78-9 | 10 | $233 | 2021-12-16 | Buy |
| Tocris | 3800 | CD2665 ≥98%(HPLC) | 170355-78-9 | 50 | $980 | 2021-12-16 | Buy |
4-[7-(1-adamantyl)-6-(2-methoxyethoxymethoxy)naphthalen-2-yl]benzoic a cid Chemical Properties,Uses,Production
Uses
CD 2665 is a selective RARβ/γ antagonist.
Biological Activity
Selective RAR β / γ antagonist (K D values are 110, 306 and > 1000 nM for RAR γ , RAR β and RAR α respectively). Blocks retinoic acid-induced apoptosis ex vivo .
in vivo
CD2665 (0.6 mg/kg; Subcutaneous injection; daily, for 22 days) completely inhibits the overexpression of RARβ mRNA in the brain of alcohol treated mice[2].
CD2665 is a selective retinoid antagonist and elicits the expected maturation delay and growth plate expansion[3].
| Animal Model: | Mice submitted to 10 months of ethanol consumption[2]. |
| Dosage: | 0.6 mg/kg |
| Administration: | Subcutaneous injection; daily, for 22 days. |
| Result: | Decreased brain RARβ mRNA levels (50% relative to control), without any change in RXR β/γ mRNA levels. |
| Animal Model: | Male and female mice (3 weeks)[3]. |
| Dosage: | 1.6 mg/kg |
| Administration: | Oral gavage/intragastric; daily, for 31 days. |
| Result: | Growth plate closure had largely been prevented in LDE225/antagonist co-treated mice compared with those receiving LDE225 only. |
storage
Store at +4°C
4-[7-(1-adamantyl)-6-(2-methoxyethoxymethoxy)naphthalen-2-yl]benzoic a cid Preparation Products And Raw materials
Raw materials
Preparation Products
4-[7-(1-adamantyl)-6-(2-methoxyethoxymethoxy)naphthalen-2-yl]benzoic a cid Suppliers
Global( 48)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32239 | 58 |
| Nanjing Doge Biomedical Technology Co., Ltd | +86-25-58227606 +86-15305155328 | sales@dogechemical.com | China | 4128 | 58 |
| TargetMol Chemicals Inc. | support@targetmol.com | United States | 38648 | 58 | |
| Aladdin Scientific | tp@aladdinsci.com | United States | 52924 | 58 | |
| 821-50328103-801 18930552037 | 3bsc@sina.com | China | 15839 | 69 | |
| BOC Sciences | 1-631-485-4226; 16314854226 | info@bocsci.com | United States | 12952 | 65 |
| Shanghai Hekang Biotechnology Co., Ltd. | 18939837085 | youchemicals@gmail.com | China | 1837 | 55 |
| EMMX Biotechnology LLC | 888-539-0666 | info@emmx.com | United States | 8447 | 60 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11218 | 58 |
| Nanjing shengyilai Chemical Co., Ltd | 19951936396 | 3158688292@qq.com | China | 4856 | 58 |
View Lastest Price from 4-[7-(1-adamantyl)-6-(2-methoxyethoxymethoxy)naphthalen-2-yl]benzoic a cid manufacturers
4-[7-(1-adamantyl)-6-(2-methoxyethoxymethoxy)naphthalen-2-yl]benzoic a cid
4-[6-[(2-Methoxyethoxy)methoxy]-7-tricyclo[3.3.1.13,7]dec-1-yl-2-naphthalenyl)benzoicacid
CD 2665
4-[7-(1-ADAMANTYL)-6-(2-METHOXYETHOXYMETHOXY)NAPHTHALEN-3-YL]BENZOIC ACID
Benzoic acid, 4-[6-[(2-methoxyethoxy)methoxy]-7-tricyclo[3.3.1.13,7]dec-1-yl-2-naphthalenyl]-
4-(7-((3r,5r,7r)-adamantan-1-yl)-6-((2-methoxyethoxy)methoxy)naphthalen-2-yl)benzoic acid
CD2665,CD-2665
CD2665, 10 mM in DMSO
170355-78-9
C31H34O5