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ChemicalBook >> CAS DataBase List >>Caspofungin acetate

Caspofungin acetate

CAS No.
179463-17-3
Chemical Name:
Caspofungin acetate
Synonyms
Cancidas;Caspofungin Diacetate;(3S,6S,9S,11R,15S,18S,20R,21S,24S,25S)-21-(2-Aminoethylamino)-3-[3-amino-1(R)-hydroxypropyl]-6-[1(S),2(S)-dihydroxy-2-(4-hydroxyphenyl)ethyl]-18-(10,12-dimethyltetradecanamido)-11,20,25-trihydroxy-15-[1(R)-hydroxyethyl]-1,4,7,13,16,22-hexaazatricyclo[22.3.0.0(9,13)]heptacosane-2,5,8,14,17,23-hexaone diacetate;Mk0991;Mk 0991;L 743872;L-743872;L 743873;L-743,872;L 743,872
CBNumber:
CB51120146
Molecular Formula:
C54H92N10O17
Molecular Weight:
1153.38
MDL Number:
MFCD08141839
MOL File:
179463-17-3.mol
MSDS File:
SDS
Last updated:2024-11-19 23:02:33

Caspofungin acetate Properties

Melting point >105°C (dec.)
storage temp. -20°C
solubility H2O: soluble15mg/mL (clear solution)
form powder
color white to beige
InChIKey OGUJBRYAAJYXQP-LLXMLGLCSA-N
FDA UNII VUW370O5QE
NCI Dictionary of Cancer Terms caspofungin acetate
NCI Drug Dictionary Cancidas

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H315-H317-H319-H335
Precautionary statements  P261-P280-P305+P351+P338
WGK Germany  3
RTECS  TP8046500
NFPA 704
0
3 0

Caspofungin acetate price More Price(50)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich SML0425 Caspofungin diacetate ≥97% (HPLC) 179463-17-3 5mg $112 2024-03-01 Buy
Sigma-Aldrich SML0425 Caspofungin diacetate ≥97% (HPLC) 179463-17-3 25mg $451 2024-03-01 Buy
Cayman Chemical 15923 Caspofungin (acetate) ≥98% 179463-17-3 1mg $32 2024-03-01 Buy
Cayman Chemical 15923 Caspofungin (acetate) ≥98% 179463-17-3 5mg $86 2024-03-01 Buy
Cayman Chemical 15923 Caspofungin (acetate) ≥98% 179463-17-3 10mg $153 2024-03-01 Buy
Product number Packaging Price Buy
SML0425 5mg $112 Buy
SML0425 25mg $451 Buy
15923 1mg $32 Buy
15923 5mg $86 Buy
15923 10mg $153 Buy

Caspofungin acetate Chemical Properties,Uses,Production

Description

Caspofungin is the first in a new class of antifungal agents named echinocandin to be launched in the US for the parenteral treatment of invasive aspergillosis in patients refractory to, or intolerant of other antifungal therapies such as amphotericin-B1 lipid formulation of amphotericin-B and/or itraconazole. Caspofungin is a water soluble, stable, aza-substituted semisynthetic derivative of pneumocandin B, a fermentation product of the fungus Zalerion arboricola. Since fungi and humans are both eukaryotes, new antifungal agents must focus on fungus-specific targets in order to minimize potential toxicity in the human host. In this respect, the lipopeptide caspofungin, inhibits the synthesis of 1,3-beta- D-glucans present only in the fungal cell wall, which leads to the specific lysis of the pathogenic cells. The compound is fungicidal rather than fungistatic, an unusual feature among antifungal agents. Caspofungin has activity in vitro and in vivo against a range of Candida species (including azole and amphotericin B resistant Candida) and also against Aspergillus, an important pathogen which is not susceptible to fluconazole. Caspofungin was generally more active than amphotericin B, flucytosine, fluconazole and itraconazole against Candida species. Cryptococcus is not susceptible to caspofungin. Caspofungin has a half-life in human beings around 10 hours. Unlike the azoles, caspofungin does not inhibit cytochrome P450. The drug has been given intravenously with loading dose of 70 rag, followed by 50 mg daily to be effective in invasive aspergillosis refractory to prior antifungal therapy. Most of the side effects were mild and comprised fever, thrombophlebitis, headache, nausea, rash and flushing.

Description

Caspofungin is an antifungal compound that is classified as an echinocandin, as it acts by noncompetititvely inhibiting the enzyme 1,3-β glucan synthase and preventing the synthesis of glucan in the fungal cell wall. It is effective against disseminated or invasive aspergillosis and candidiasis in mice. Caspofungin has a 50% minimum effective concentration against Aspergillus spp. of 0.015 μg/ml. It does not antagonize other antifungal compounds, like amphotericin B, and, in some cases, may show additive or synergistic activity.

Chemical Properties

White Solid

Originator

Merck & Co (US)

Uses

Calcium antagonist, coronary vasodilator, anti-inflammatory, analgesic

Uses

Caspofungin Diacetate is an impurity of Caspofungin Acetate(C184900) which is an echinocandin that inhibits the synthesis of β (1,3)-D-glucan, an integral component of the fungal cell wall. An antifungal drug used in the treatment of invasive fungal infections.

Uses

Caspofungin acetate is a semi-synthetic analogue of pneumocandin B0 with improved water solubility, a significant limitation in the development of the echinocandin class as pharmaceuticals. Caspofungin acetate acts by inhibiting the synthesis of β-(1,3)-D-glucan, an essential component of the cell wall of susceptible fungi.

Definition

ChEBI: The diacetate salt of caspofungin. It is used for the treatment of invasive candidiasis, and of aspergillosis in patients who are refractory to, or intolerant of, other therapy.

brand name

Cancidas (Merck).

Biochem/physiol Actions

Caspofungin is an echinocandin antifungal that inhibits 1,3-β-D-glucan synthase, which is required for cell wall synthesis, thereby disturbing the integrity of the fungal cell wall.

Veterinary Drugs and Treatments

Caspofungin has potential for treating invasive aspergillosis or disseminated candidal infections in companion animals although little, if any, information on its use in dogs or cats is available.

Caspofungin acetate Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 356)Suppliers
Supplier Tel Email Country ProdList Advantage
Hebei Yanxi Chemical Co., Ltd. 		+8617531190177 peter@yan-xi.com China 5857 58
Hebei Weibang Biotechnology Co., Ltd 		+8617732866630 bess@weibangbio.com China 18151 58
Henan Bao Enluo International TradeCo.，LTD 		+86-17331933971 +86-17331933971 deasea125996@gmail.com China 2472 58
Zibo Hangyu Biotechnology Development Co., Ltd 		+86-0533-2185556 +8617865335152 Mandy@hangyubiotech.com China 10986 58
Shaanxi Haibo Biotechnology Co., Ltd 		+undefined18602966907 qinhe02@xaltbio.com China 997 58
Alpha Biopharmaceuticals Co., Ltd 		+86-15542445688 sales@alphabiopharm.com China 992 58
Capot Chemical Co.,Ltd. 		+86-（0）57185586718 +86-13336195806 sales@capot.com China 29791 60
Beijing Cooperate Pharmaceutical Co.,Ltd 		010-60279497 sales01@cooperate-pharm.com CHINA 1803 55
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21634 55
Shanghai Yingrui Biopharma Co., Ltd. 		+86-21-33585366 - 03@ sales03@shyrchem.com CHINA 738 60

View Lastest Price from Caspofungin acetate manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Caspofungin Acetate pictures 2024-11-19 Caspofungin Acetate
179463-17-3
 US $52.00-157.00 / mg 99.9% 10g TargetMol Chemicals Inc.
Caspofungin acetate pictures 2024-10-25 Caspofungin acetate
179463-17-3
 US $0.00 / kg 1kg 0.99 20 tons Hebei Yanxi Chemical Co., Ltd.
Caspofungin acetate pictures 2024-10-24 Caspofungin acetate
179463-17-3
 US $0.00-0.00 / KG 1KG 99% 500000kg Hebei Weibang Biotechnology Co., Ltd

Caspofungin acetate Spectrum

Caspofungin acetate Caspofungin acetate [USAN:BAN:JAN] L 743,872 L 743872 L-743,872 L-743872 Mk 0991 Mk0991 Pneumocandin B0, 1-((4R,5S)-5-((2-aminoethyl)amino)-N2-(10,12-dimethyl-1-oxotetradecyl)-4-hydroxy-L-ornithine)-5-((3R)-3-hydroxy-L-ornithine)-, diacetate (salt) 1-[(4R,5S)-5-[(2-AMinoethyl)aMino]-N2-[(10R,12S)-10,12-diMethyl-1-oxotetradecyl]-4-hydroxy-L-ornithine]-5-(threo-3-hydroxy-L-ornithine)pneuMocandin B0 Diacetate 1-[(4R,5S)-5-[(2-AMinoethyl)aMino]-N2-[(10R,12S)-10,12-diMethyl-1-oxotetradecyl]-4-hydroxy-L-ornithine]-5-[(3R)-3-hydroxy-L-ornithine]pneuMocandin B0 Diacetate L 743873 Cancidas, L-743,872, MK-0991 Cancidas (Caspofungin Acetate) Pneumocandin B0, 1-[(4R,5S)-5-[(2-aminoethyl)amino]-N2-[(10R,12S)-10,12-dimethyl-1-oxotetradecyl]-4-hydroxy-L-ornithine]-5-[(3R)-3-hydroxy-L-ornithine]-, acetate (1:2) (3S,6S,9S,11R,15S,18S,20R,21S,24S,25S)-21-(2-Aminoethylamino)-3-[3-amino-1(R)-hydroxypropyl]-6-[1(S),2(S)-dihydroxy-2-(4-hydroxyphenyl)ethyl]-18-(10,12-dimethyltetradecanamido)-11,20,25-trihydroxy-15-[1(R)-hydroxyethyl]-1 Caspofungin acetate Cancidas 1-[(4R,5S)-5-[(2-Aminoethyl)amino]-N2-(10,12-dimethyl-1-oxotetradecyl)-4-hydroxy-L-ornithine]-5-[(3R)-3-hydroxy-L-ornithine]-pneumocandin B0 Caspofungin diacetate, >=98% Casp ungin Acetate Caspofungin Acetate (L 743872 Caspofungin Acetate for lnjection Cancidas, ≥98% Casporfungin Acetate CF/KB(EUGMP,GMP) L 743872;L 743873;MK 0991;MK-0991 Caspofungin acetate USP/EP/BP Caspofungin diacetate salt Caspofungin acetate B0 pofungin Acetate (10R,12S)-N-((2R,6S,9S,11R,12S,14aS,15S,20S,23S,25aS)-20-((R)-3-Amino-1-hydroxypropyl)-12-((2-aminoethyl)amino)-23-((1S,2S)-1,2-dihydroxy-2-(4-hydroxyphenyl)ethyl)-2,11,15-trihydroxy-6-((R)-1-hydroxyethyl)-5,8,14,19,22,25-hexaoxotetracosahydro-1H-dipyrrolo[2,1-c:2',1'-l][1,4,7,10,13,16]hexaazacyclohenicosin-9-yl)-10,12-dimethyltetradecanamide diacetate Caspofungin Acetate (MK0991) (10R,12S)-N-((2R,6S,9S,11R,12S,14aS,15S,20S,23S,25aS)-20-((R)-3-Amino-1-hydroxypropyl)-12-((2-aminoethyl)amino)-23-((1S,2S)-1,2-dihydroxy-2-(4-hydroxyphenyl)ethyl)-2,11,15-trihydroxy-6-((R)-1-hydroxyethyl)-5,8,14,19,22,25-hexaoxotetracosahydro-1H-dipyrrol US-DMF No.: 034091 ASMF Approved Caspofungin Diacetate Cancidas (3S,6S,9S,11R,15S,18S,20R,21S,24S,25S)-21-(2-Aminoethylamino)-3-[3-amino-1(R)-hydroxypropyl]-6-[1(S),2(S)-dihydroxy-2-(4-hydroxyphenyl)ethyl]-18-(10,12-dimethyltetradecanamido)-11,20,25-trihydroxy-15-[1(R)-hydroxyethyl]-1,4,7,13,16,22-hexaazatricyclo[22.3.0.0(9,13)]heptacosane-2,5,8,14,17,23-hexaone diacetate Bamifylline Impurity 2 Caspofungin Acetate (>90%) Carpofungin acetate Gaspofungin Acetate (10R,12S)-N-((2R,6S,9S,11R,12S,14aS,15S,20S,23S,25aS)-20-((R)-3-amino-1-hydroxypropyl)-12-((2-aminoethyl)amino)-23-((1S,2S)-1,2-dihydroxy-2-(4-hydroxyphenyl)ethyl)-2,11,15-trihydroxy-6-((R)-1-hydroxyethyl)-5,8,14,19,22,25-hexaoxotetracosahydro-1H-dipyrrolo[2,1-c:2',1'-l][1,4,7,10,13,16]hexaazacyclohenicosin-9-yl)-10,12-dimethyltetradecanamide acetate (10R,12S)-N-((2R,6S,9S,11R,12S,14aS,15S,20S,23S,25aS)-20-((R)-3-Amino-1-hydroxypropyl)-12-((2-aminoethyl)amino)-23-((1S,2S)-1,2-dihydroxy-2-(4-hydroxyphenyl)ethyl)-2,11,15-trihydroxy-6-((R)-1-hydroxyethyl)-5,8,14,19,22,25-hexaoxotetracosahydro-1H-dipyrrolo[2,1-c:2',1'-l][1,4,7,10,13,16]hexaazacyclohenicosin-9-yl)-10,12-dimethyltetradecanamide diacetate (10R,12S)-N-((2R,6S,9S,11R,12S,14aS,15S,20S,23S,25aS)-20-((R)-3-Amino-1-hydroxypropyl)-12-((2-aminoethyl)amino)-23-((1S,2S)-1,2-dihydroxy-2-(4-hydroxyphenyl)ethyl)-2,11,15-trihydroxy-6-((R)-1-hydroxyethyl)-5,8,14,19,22,25-hexaoxotetracosahydro-1H-dipyrrolo[2,1-C:2',1'-l][1,4,7,10,13,16]hexaazacyclohenicosin-9-yl)-10,12-dimethyltetradecanamide acetate 179463-17-3 179643-17-3 79463-17-3 C56H96N10O19 C52H88N10O152C2H4O2 API Amines Heterocycles Inhibitors Intermediates & Fine Chemicals Pharmaceuticals