3H-Cyclopenta[c]quinoline, 4-(5-bromo-2-methoxyphenyl)-8-fluoro-3a,4,5,9b-tetrahydro-, (3aR,4S,9bS)-rel-
![3H-Cyclopenta[c]quinoline, 4-(5-bromo-2-methoxyphenyl)-8-fluoro-3a,4,5,9b-tetrahydro-, (3aR,4S,9bS)-rel- Structure](CAS/20210305/GIF/415919-74-3.gif)
- CAS No.
- 415919-74-3
- Chemical Name:
- 3H-Cyclopenta[c]quinoline, 4-(5-bromo-2-methoxyphenyl)-8-fluoro-3a,4,5,9b-tetrahydro-, (3aR,4S,9bS)-rel-
- Synonyms
- GPR30 agonist-1;3H-Cyclopenta[c]quinoline, 4-(5-bromo-2-methoxyphenyl)-8-fluoro-3a,4,5,9b-tetrahydro-, (3aR,4S,9bS)-rel-
- CBNumber:
- CB48979265
- Molecular Formula:
- C19H17BrFNO
- Molecular Weight:
- 374.25
- MDL Number:
- MOL File:
- 415919-74-3.mol
3H-Cyclopenta[c]quinoline, 4-(5-bromo-2-methoxyphenyl)-8-fluoro-3a,4,5,9b-tetrahydro-, (3aR,4S,9bS)-rel- Properties
| Boiling point | 446.7±45.0 °C(Predicted) |
|---|---|
| Density | 1.394±0.06 g/cm3(Predicted) |
| solubility | DMSO : 50 mg/mL (133.60 mM; ultrasonic and warming and heat to 80°C) |
| pka | 4.32±0.40(Predicted) |
| form | Solid |
| color | White to off-white |
3H-Cyclopenta[c]quinoline, 4-(5-bromo-2-methoxyphenyl)-8-fluoro-3a,4,5,9b-tetrahydro-, (3aR,4S,9bS)-rel- Chemical Properties,Uses,Production
Uses
GPR30 agonist-1 is a G protein-coupled receptor 30 (GPR30) agonist. GPR30 agonist-1 exerts vasorelaxant effects[1].
in vivo
GPR30 agonist-1 (compound 5408-0877) (1 nM-10 μM) induces a concentration-dependent relaxation in carotid arteries from both male and female rats. GPR30 agonist-1-induced relaxation is abolished by endothelium removal and abrogated in the presence of the nitric oxide synthase inhibitor NG-nitro-l-arginine methyl ester (100 μM)[1].
References
[1] Brad R S Broughton, et al. Endothelium-dependent relaxation by G protein-coupled receptor 30 agonists in rat carotid arteries. Am J Physiol Heart Circ Physiol. 2010 Mar;298(3):H1055-61. DOI:10.1152/ajpheart.00878.2009
3H-Cyclopenta[c]quinoline, 4-(5-bromo-2-methoxyphenyl)-8-fluoro-3a,4,5,9b-tetrahydro-, (3aR,4S,9bS)-rel- Preparation Products And Raw materials
Raw materials
Preparation Products
3H-Cyclopenta[c]quinoline, 4-(5-bromo-2-methoxyphenyl)-8-fluoro-3a,4,5,9b-tetrahydro-, (3aR,4S,9bS)-rel- Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | support@targetmol.com | United States | 38664 | 58 | |
| Aladdin Scientific | tp@aladdinsci.com | United States | 52924 | 58 | |
| Beijing Jin Ming Biotechnology Co., Ltd. | 010-60605840 15801484223; | psaitong@jm-bio.com | China | 29772 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 11973 | 58 |
| TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 20036 | 58 |
| Supplier | Advantage |
|---|---|
| TargetMol Chemicals Inc. | 58 |
| Aladdin Scientific | 58 |
| Beijing Jin Ming Biotechnology Co., Ltd. | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 58 |
| TargetMol Chemicals Inc. | 58 |
View Lastest Price from 3H-Cyclopenta[c]quinoline, 4-(5-bromo-2-methoxyphenyl)-8-fluoro-3a,4,5,9b-tetrahydro-, (3aR,4S,9bS)-rel- manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-10-28 | GPR30 agonist-1
415919-74-3
|
US $73.00 / mg | 10g | TargetMol Chemicals Inc. |
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- GPR30 agonist-1
415919-74-3
- US $73.00 / mg
- TargetMol Chemicals Inc.