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ChemicalBook >> CAS DataBase List >>4-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione

4-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione

CAS No.
1957236-10-0
Chemical Name:
4-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione
Synonyms
Thalidomide-4-PEG3-NH2;Thalidomide-O-PEG2-amine;Thalidomide-O-PEG2-Amine TFA salt;4-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione;4-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]-2-(2,6-dioxo-3-piperidyl)isoindoline-1,3-dione;4-(2-(2-(2-aminoethoxy)ethoxy)ethoxy)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione;4-[2-[2-(2-Aminoethoxy)ethoxy]ethoxy]-2-(2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione;1H-Isoindole-1,3(2H)-dione, 4-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]-2-(2,6-dioxo-3-piperidinyl)-;4-{2-[2-(2-aminoethoxy)ethoxy]ethoxy}-2-(2,6-dioxopiperidin-3-yl)-2,3-dihydro-1H-isoindole-1,3-dione
CBNumber:
CB45851966
Molecular Formula:
C19H23N3O7
Molecular Weight:
405.4
MDL Number:
MOL File:
1957236-10-0.mol
Last updated:2025-04-18 09:52:21

4-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione Properties

Boiling point 648.7±55.0 °C(Predicted)
Density 1.375±0.06 g/cm3(Predicted)
pka 10.70±0.40(Predicted)

4-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione Chemical Properties,Uses,Production

Uses

Thalidomide-PEG3-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology[1].

IC 50

Cereblon

References

[1] Sato T, et al. Cereblon-Based Small-Molecule Compounds to Control Neural Stem Cell Proliferation in Regenerative Medicine.?Front Cell Dev Biol. 2021;9:629326. Published 2021 Mar 11. DOI:10.3389/fcell.2021.629326
[2] Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-997. DOI:10.1016/j.immuni.2020.07.018

4-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione Preparation Products And Raw materials

Raw materials

Preparation Products

4-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione Suppliers

Global( 7)Suppliers
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Daicel Chiral Technologies (China)CO.,LTD 021-50460086-9 15921403865 han_yajun@dctc.daicel.com China 6576 65
Jilin Province Woda Biotechnology Co., Ltd. 13504435624 1927928688@qq.com China 1592 58
Binhai gill polypeptide co. LTD 021-61263389 13524856427 Joetang@glschina.com China 9801 58
Nanjing Bestfluorodrug Pharmaceutical Technology CO.,LTD 025-86755008 17751752005 hszhang@bestfluorodrug.com China 2358 58
Shanghai Easy CDMO Co.,Ltd 021-61734564 13854185395; info@easycdmo.com China 10030 58
Nanjing Bestfluorodrug Pharmaceutical Technology CO.,LTD 025-86755008 17751752005 hszhang@bestfluorodrug.com China 2788 58
Jilin Chinese Academy of Sciences-yanshen Technology 18143011203 ET-market@chemextension.com China 27851 58
4-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione 1H-Isoindole-1,3(2H)-dione, 4-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]-2-(2,6-dioxo-3-piperidinyl)- Thalidomide-O-PEG2-amine 4-(2-(2-(2-aminoethoxy)ethoxy)ethoxy)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione 4-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]-2-(2,6-dioxo-3-piperidyl)isoindoline-1,3-dione Thalidomide-4-PEG3-NH2 4-[2-[2-(2-Aminoethoxy)ethoxy]ethoxy]-2-(2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione Thalidomide-O-PEG2-Amine TFA salt 4-{2-[2-(2-aminoethoxy)ethoxy]ethoxy}-2-(2,6-dioxopiperidin-3-yl)-2,3-dihydro-1H-isoindole-1,3-dione 1957236-10-0