AN11251
- CAS No.
- 2130750-59-1
- Chemical Name:
- AN11251
- Synonyms
- AN11251;AN-11251,AN11251;(3aR,4R,5R,7S,8S,9R,9aS,12R)-8-Hydroxy-4,7,9,12-tetramethyl-3-oxo-7-vinyldecahydro-4,9a-propanocyclopenta[8]annulen-5-yl 2-((7-fluor o-1-hydroxy-1,3-dihydrobenzo[C][1,2]-oxaborol-6-yl)oxy)acetate;Acetic acid, 2-[(7-fluoro-1,3-dihydro-1-hydroxy-2,1-benzoxaborol-6-yl)oxy]-, (3aS,4R,5S,6S,8R,9R,9aR,10R)-6-ethenyldecahydro-5-hydroxy-4,6,9,10-tetramethyl-1-oxo-3a,9-propano-3aH-cyclopentacycloocten-8-yl ester
- CBNumber:
- CB45821109
- Molecular Formula:
- C29H38BFO7
- Molecular Weight:
- 528.42
- MDL Number:
- MFCD31813806
- MOL File:
- 2130750-59-1.mol
AN11251 Chemical Properties,Uses,Production
Description
AN11251 is a potenet Anti-Wolbachia Agent with Potential for Treatment of Onchocerciasis and Lymphatic Filariasis (EC50 = 1.5nM for LDW1 cell lines and 15 nM for C6/36 cell lines). AN11251 showed in vitro anti-Wolbachia activity and physicochemical and pharmacokinetic properties providing high exposure in plasma.
Uses
AN11251 is a potent and oral active anti-Wolbachia agent with potential for treatment of onchocerciasis and lymphatic filariasis, with EC50 values of 1.5 nM in LDW1 cell lines and 15 nM in C6/36 cell lines[1].
in vivo
AN11251 (25 mg/kg, PO, BID for 7 or 14 days) reduces the Wolbachia load in the B. malayi larvae by 75.4% and 98.8% in the 7- and 14-day treatment groups, respectively[1].
| Animal Model: | CB.17 SCID mice inoculated with 50 L3-stage B. malayi larvae[1]. |
| Dosage: | 25 mg/kg. |
| Administration: | Orally, BID for 7 or 14 days. |
| Result: | Reduced the Wolbachia load in the B. malayi larvae by 75.4% and 98.8% in the 7- and 14-day treatment groups, respectively. |
References
[1] Jacobs RT, et al. Boron-Pleuromutilins as Anti- Wolbachia Agents with Potential for Treatment of Onchocerciasis and Lymphatic Filariasis. J Med Chem. 2019 Mar 14;62(5):2521-2540. DOI:10.1021/acs.jmedchem.8b01854
AN11251 Preparation Products And Raw materials
Raw materials
Preparation Products
AN11251 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32239 | 58 |
| TargetMol Chemicals Inc. | support@targetmol.com | United States | 38648 | 58 | |
| TargetMol Chemicals Inc. | +8613564774135 | zijue.cai@tsbiochem.com | United States | 19897 | 58 |
| Fan De(Beijing) Biotechnology Co., Ltd. | 15911056312 | liming@bio-fount.com | China | 9729 | 58 |
| TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 19820 | 58 |
| Biosynth Biological Technology (Suzhou) Co Ltd | 51288865780 | sales@biosynth.com | China | 233051 | 58 |
| Adooq Bioscience LLC | 400-025-6535 | sales@adooq.cn | China | 18215 | 58 |
