N-(3R)-1-Azabicyclo[2.2.2]oct-3-yl-furo[2,3-c]pyridine-5-carboxamide hydrochloride
![N-(3R)-1-Azabicyclo[2.2.2]oct-3-yl-furo[2,3-c]pyridine-5-carboxamide hydrochloride Structure](CAS/20200331/GIF/1586767-92-1.gif)
- CAS No.
- 1586767-92-1
- Chemical Name:
- N-(3R)-1-Azabicyclo[2.2.2]oct-3-yl-furo[2,3-c]pyridine-5-carboxamide hydrochloride
- Synonyms
- CBNumber:
- CB44902801
- Molecular Formula:
- C15H18ClN3O2
- Molecular Weight:
- 307.78
- MDL Number:
- MOL File:
- 1586767-92-1.mol
| solubility | Soluble to 100 mM in water and to 25 mM in DMSO |
|---|---|
| FDA UNII | 13XQH31A5R |
N-(3R)-1-Azabicyclo[2.2.2]oct-3-yl-furo[2,3-c]pyridine-5-carboxamide hydrochloride Chemical Properties,Uses,Production
Uses
PHA-543613 hydrochloride is an oral or active α7 nAChR agonist with brain permeability, For α3β4, α1β1γδ, α4β2 and 5-HT3 receptors selective. PHA-543613 hydrochloride affects sensory gating and memory in an in vivo model of schizophrenia[1][1].
storage
Store at +4°C
References
[1] Faghih R, et al. Allosteric modulators of the alpha7 nicotinic acetylcholine receptor. J Med Chem. 2008 Feb 28;51(4):701-12. DOI:10.1021/jm070256g
[2] Wishka DG, et al. Discovery of N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]furo[2,3-c]pyridine-5-carboxamide, an agonist of the alpha7 nicotinic acetylcholine receptor, for the potential treatment of cognitive deficits in schizophrenia: synthesis and structure--activity relationship. J Med Chem. 2006 Jul 13;49(14):4425-36. DOI:10.1021/jm0602413
N-(3R)-1-Azabicyclo[2.2.2]oct-3-yl-furo[2,3-c]pyridine-5-carboxamide hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
N-(3R)-1-Azabicyclo[2.2.2]oct-3-yl-furo[2,3-c]pyridine-5-carboxamide hydrochloride Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Aladdin Scientific | tp@aladdinsci.com | United States | 52924 | 58 | |
| Suzhou Zhixin Biotechnology Co., Ltd. | 0512-65118909 15162312715 | sales@szzxbio.com | China | 2982 | 58 |
| Nantong QuanYi Biotechnology Co., Ltd | 0513-66337626 18051384581 | sales@chemhifuture.com | China | 5519 | 58 |
| TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 20017 | 58 |
| R&D Systems, Inc | 18003437475 18003437475 | rdname@qq.com | China | 35960 | 58 |
| Supplier | Advantage |
|---|---|
| Aladdin Scientific | 58 |
| Suzhou Zhixin Biotechnology Co., Ltd. | 58 |
| Nantong QuanYi Biotechnology Co., Ltd | 58 |
| TargetMol Chemicals Inc. | 58 |
| R&D Systems, Inc | 58 |