PDGFR Tyrosine Kinase Inhibitor V
- CAS No.
- 347155-76-4
- Chemical Name:
- PDGFR Tyrosine Kinase Inhibitor V
- Synonyms
- Ki11502;Ki11502 >=98% (HPLC);PDGFR Tyrosine Kinase Inhibitor V;Benzamide, N-[[[4-[(6,7-dimethoxy-4-quinolinyl)oxy]phenyl]amino]thioxomethyl]-2-methyl-
- CBNumber:
- CB43352599
- Molecular Formula:
- C26H23N3O4S
- Molecular Weight:
- 473.54
- MDL Number:
- MOL File:
- 347155-76-4.mol
- MSDS File:
- SDS
| Density | 1.312±0.06 g/cm3(Predicted) |
|---|---|
| storage temp. | 2-8°C |
| solubility | DMSO: 25mg/mL |
| pka | 8.69±0.70(Predicted) |
| form | powder |
| color | white to brown |
| FDA UNII | LEB9DP4H6C |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H413 |
| Precautionary statements | P264-P270-P301+P312-P330-P501 |
PDGFR Tyrosine Kinase Inhibitor V price More Price(3)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 521234 | PDGFR Tyrosine Kinase Inhibitor V - CAS 347155-76-4 - Calbiochem | 347155-76-4 | 1mg | $272 | 2024-03-01 | Buy |
| Sigma-Aldrich | SML1161 | Ki11502 ≥98% (HPLC) | 347155-76-4 | 5MG | $115 | 2023-06-20 | Buy |
| Sigma-Aldrich | SML1161 | Ki11502 ≥98% (HPLC) | 347155-76-4 | 25MG | $423 | 2022-05-15 | Buy |
PDGFR Tyrosine Kinase Inhibitor V Chemical Properties,Uses,Production
Definition
ChEBI: Ki11502 is a member of the class of quinolines that acts as a receptor tyrosine kinase inhibitor and apoptosis inducer with potential for use in treatment of leukemia and colorectal cancer. It has a role as an EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor, an apoptosis inducer and an antineoplastic agent. It is a member of quinolines, a member of thioureas, an aromatic ether and a member of benzamides.
General Description
A cell-permeable quinolinyl-thiourea compound that acts a potent, ATP-competitive, and reversible inhibitor of PDGFR (IC50 = 4 and 7.6 nM in ligand-induced cellular PDGFR phosphorylation and in in vitro kinase activity, respectively). Inhibits c-kit receptor only at much higher concentrations (IC50 = 434 and 234 nM in receptor phosphorylation and kinase activity, respectively). Shown to potently inhibit neointima formation in a rat carotid artery balloon injury model in vivo (30 mg/kg, p.o.).
Biochem/physiol Actions
Cell permeable: yes
PDGFR Tyrosine Kinase Inhibitor V Preparation Products And Raw materials
Raw materials
Preparation Products
PDGFR Tyrosine Kinase Inhibitor V Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51456 | 80 |
| Energy Chemical | 021-58432009 400-005-6266 | marketing@energy-chemical.com | China | 44918 | 58 |
| Merck KGaA | (+86) 21 2033 8288 | sigmaname@qq.com | CHINA | 292394 | 58 |
| Supplier | Advantage |
|---|---|
| Sigma-Aldrich | 80 |
| Energy Chemical | 58 |
| Merck KGaA | 58 |