[1,1′-Biphenyl]-4-sulfonamide, N-[1,2,3,4-tetrahydro-1-(methylsulfonyl)-7-quinolinyl]-
- CAS No.
- 1209698-02-1
- Chemical Name:
- [1,1′-Biphenyl]-4-sulfonamide, N-[1,2,3,4-tetrahydro-1-(methylsulfonyl)-7-quinolinyl]-
- Synonyms
- NLRP3-IN-41;[1,1′-Biphenyl]-4-sulfonamide, N-[1,2,3,4-tetrahydro-1-(methylsulfonyl)-7-quinolinyl]-
- CBNumber:
- CB414651661
- Molecular Formula:
- C22H22N2O4S2
- Molecular Weight:
- 442.55
- MDL Number:
- MOL File:
- 1209698-02-1.mol
[1,1′-Biphenyl]-4-sulfonamide, N-[1,2,3,4-tetrahydro-1-(methylsulfonyl)-7-quinolinyl]- Chemical Properties,Uses,Production
Uses
NLRP3-IN-41 (compd S-9) is an orally active and brain-penetrant NLRP3 inhibitor with anti-inflammatory activities, anti-neuroinflammatory effect and without obvious cytotoxicity. NLRP3-IN-41 inhibits the priming and activation stages of the NLRP3 inflammasome and can be used for inflammasome-related diseases research[1].
in vivo
NLRP3-IN-41 (40, 80 mg/kg, i.g., 10 days) attenuates the symptoms of DSS-induced colitis in C57BL/6 and ICR mice[1].
IC 50
NLRP3
References
[1] Yang F, et al. Identification and Validation of PKR as a Direct Target for the Novel Sulfonamide-Substituted Tetrahydroquinoline Nonselective Inhibitor of the NLRP3 Inflammasome. J Med Chem. 2024 Jun 10. DOI:10.1021/acs.jmedchem.4c00343
[1,1′-Biphenyl]-4-sulfonamide, N-[1,2,3,4-tetrahydro-1-(methylsulfonyl)-7-quinolinyl]- Preparation Products And Raw materials
Raw materials
Preparation Products
[1,1′-Biphenyl]-4-sulfonamide, N-[1,2,3,4-tetrahydro-1-(methylsulfonyl)-7-quinolinyl]- Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Shanghai Beckham Medical Technology Co., Ltd | 021-13816613772 13816613772 | huahero21@sina.com | China | 997 | 55 |
Supplier | Advantage |
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Shanghai Beckham Medical Technology Co., Ltd | 55 |