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ChemicalBook >> CAS DataBase List >>Neostigmine bromide

Neostigmine bromide

CAS No.
114-80-7
Chemical Name:
Neostigmine bromide
Synonyms
Prostigmi;Neostigmin;Neoesserin;prostigmin;Neoserine);Juvastigmin;PROSTIGMINE;stigmosanbromide;stigmanolbromide;eustigminbromide
CBNumber:
CB3677212
Molecular Formula:
C12H19BrN2O2
Molecular Weight:
303.2
MDL Number:
MFCD00011795
MOL File:
114-80-7.mol
MSDS File:
SDS
Last updated:2024-12-18 14:08:57

Neostigmine bromide Properties

Melting point 175-177 °C(lit.)
Density 1.4344 (rough estimate)
refractive index 1.5410 (estimate)
storage temp. Inert atmosphere,Room Temperature
solubility H2O: 1 g/mL
form powder
color white
PH 5.2～6.2 (100g/l, 25℃)
Water Solubility 1 g/ mL
Merck 14,6464
BCS Class 3
FDA UNII 005SYP50G5
EPA Substance Registry System Benzenaminium, 3-[[(dimethylamino)carbonyl]oxy]-N,N,N-trimethyl-, bromide (114-80-7)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictogramsGHS hazard pictograms
GHS06,GHS08
Signal word  Danger
Hazard statements  H300+H310+H330-H315-H317-H319-H334-H335
Precautionary statements  P262-P280-P301+P310+P330-P302+P352+P310-P304+P340+P310-P305+P351+P338
Hazard Codes  T+,T
Risk Statements  26/27/28-36/37/38-42/43-25
Safety Statements  22-26-36/37/39-45-37/39-28A
RIDADR  UN 2811 6.1/PG 2
WGK Germany  3
RTECS  BR3150000
HazardClass  6.1(a)
PackingGroup  II
HS Code  29239000
NFPA 704
0
4 0

Neostigmine bromide price More Price(33)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich N2001 Neostigmine bromide ≥98% (HPLC and titration), powder 114-80-7 1g $116 2024-03-01 Buy
Sigma-Aldrich 1459001 Neostigmine bromide United States Pharmacopeia (USP) Reference Standard 114-80-7 200mg $250 2024-03-01 Buy
TCI Chemical N0358 Neostigmine Bromide >99.0%(T) 114-80-7 5g $90 2024-03-01 Buy
TCI Chemical N0358 Neostigmine Bromide >99.0%(T) 114-80-7 25g $294 2024-03-01 Buy
Alfa Aesar J62300 Neostigmine bromide 114-80-7 250mg $47.65 2024-03-01 Buy
Product number Packaging Price Buy
N2001 1g $116 Buy
1459001 200mg $250 Buy
N0358 5g $90 Buy
N0358 25g $294 Buy
J62300 250mg $47.65 Buy

Neostigmine bromide Chemical Properties,Uses,Production

Chemical Properties

Crystalline Solid

Uses

Neostigmine bromide has been used as an acetyl cholinesterase (AChE) inhibitor:

  • to control reaction specificity of acetylcholinesterase in coronal organ of Botryllus schlosseri.
  • to study its effects on abnormal contraction of pyloric circular smooth muscle strips (PCSMS).
  • to study its effects on depolarization of bag cell neurons.

Uses

A reversible acetylcholinesterase inhibitor

Uses

antiscorbutic, antiviral

Uses

Cholinergic; miotic; antidote (curare)

Definition

ChEBI: Neostigmine bromide is the bromide salt of neostigmine. It contains a neostigmine.

General Description

Neostigmine bromide, (m-hydroxyphenyl)trimethylammonium bromide dimethylcarbamateor the dimethylcarbamic ester of 3-hydroxyphenyltrimethylammoniumbromide (Prostigmin bromide), is usedas an antidote to nondepolarizing neuromuscular blockingdrugs and in the treatment of myasthenia gravis. It occurs asa bitter, odorless, white, crystalline powder. It is soluble inwater and alcohol. The crystals are much less hygroscopicthan those of neostigmine methylsulfate and thus may beused in tablets. Solutions are stable and may be sterilized byboiling. Aqueous solutions are neutral to litmus.

Biological Activity

neostigmine bromide is a reversible inhibitor of acetylcholinesterase.[1]ache (acetylcholinesterase) is a hydrolase that hydrolyzes the neurotransmitter acetylcholine at the neuromuscular junction and cholinergic synaspe. it terminates the signal transductions and plays a role in neuronal apoptosis.neostigmine bromide is a quaternary amine that blocked cholinesterase activity to extend and enhance the muscarinic and nicotinic effects of acetylcholine. it is implicated for the treatment of primary open-angle glaucoma, postoperative urinary retention, paralytic ileus, myasthenia gravis etc. it is also reported to be an adjuvant to local anaesthetics and opioids for post-surgical pain after gynaecological or abdominal surgery. [1]

Biochem/physiol Actions

Neostigmine bromide is a quaternary amine. It is involved in elongating and boosting the muscarinic and nicotinic effects of acetylcholine by inhibiting cholinesterase activity. It is used in anesthesia to reverse the neuromuscular blockade produced by competitive neuromuscular blockers.

Clinical Use

Use of physostigmine, as a prototype of an indirect-actingparasympathomimetic drug, facilitated the development ofstigmine, in which a trimethylamine group was placed para toa dimethylcarbamate group in benzene. Better inhibition ofcholinesterase was observed when these groups were placedmeta to each other as in neostigmine, a more active and usefulagent. Although physostigmine contains a methylcarbamatefunctional group, greater chemical stability towardhydrolysis was obtained with the dimethylcarbamyl group inneostigmine.

Safety Profile

Poison by ingestion, subcutaneous, intravenous, and intraperitoneal routes. When heated to decomposition it emits very toxic fumes of Br-, NH3, and NOx. See also CARBAMATES and BROMIDES.

Purification Methods

Crystallise neostigmine bromide from EtOH/diethyl ether. Its solubility in H2O is ~50%. [Beilstein 13 III 939.] (It is cholinergic and highly TOXIC.) The starting material 3-dimethylcarbamoyl-N,N-dimethylaniline [59-99-4] has b 195o/20mm [Beilstein 13 III 936], and its picrate has m 138o (from EtOH).

References

[1] el-kosasy am, nebsen m, abd el-rahman mk, salem my, el-bardicy mg. comparative study of 2-hydroxy propyl beta cyclodextrin and calixarene as ionophores in potentiometric ion-selective electrodes for neostigmine bromide. talanta. 2011 aug 15;85(2):913-8.

99-07-0
114-80-7
Synthesis of Neostigmine bromide from 3-Dimethylaminophenol

Neostigmine bromide Preparation Products And Raw materials

Global( 237)Suppliers
Supplier Tel Email Country ProdList Advantage
Hebei Weibang Biotechnology Co., Ltd 		+8615531157085 abby@weibangbio.com China 8810 58
Hebei Mojin Biotechnology Co., Ltd 		+86 13288715578 +8613288715578 sales@hbmojin.com China 12835 58
Hangzhou ICH Biofarm Co., Ltd 		+86-0571-28186870; +undefined8613073685410 sales@ichemie.com China 1001 58
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21634 55
career henan chemical co 		+86-0371-86658258 +8613203830695 sales@coreychem.com China 29880 58
SHANDONG ZHI SHANG CHEMICAL CO.LTD 		+86 18953170293 sales@sdzschem.com China 2930 58
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Chongqing Chemdad Co., Ltd 		+86-023-6139-8061 +86-86-13650506873 sales@chemdad.com China 39894 58
CONIER CHEM AND PHARMA LIMITED 		+8618523575427 sales@conier.com China 49374 58
SIMAGCHEM CORP 		+86-13806087780 sale@simagchem.com China 17365 58

View Lastest Price from Neostigmine bromide manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Neostigmine bromide pictures 2024-11-05 Neostigmine bromide
114-80-7
 US $10.00 / KG 1KG 99% 10 mt Hebei Weibang Biotechnology Co., Ltd
Neostigmine bromide pictures 2023-11-01 Neostigmine bromide
114-80-7
 US $0.00-0.00 / g 1g 98% 100kg Hangzhou ICH Biofarm Co., Ltd
Neostigmine bromide pictures 2023-09-06 Neostigmine bromide
114-80-7
 US $0.00 / KG 1KG 99% 50000KG/month Hebei Mojin Biotechnology Co., Ltd
stigmanolbromide stigmosanbromide synstigminbromide (3-HYDROXYPHENYL)TRIMETHYLAMMONIUM BROMIDE DIMETHYL CARBAMATE 3-[[(DIMETHYLAMINO)CARBONYL]OXY]-N,N,N-TRIMETHYLBENZAMINIUM BROMIDE 3-[[(DIMETHYLAMINO)CARBONYL]OXY]-N,N,N-TRIMETHYLBENZENAMINIUM BROMIDE (3-DIMETHYLCARBAMOYLOXYPHENYL)TRIMETHYLAMMONIUM BROMIDE Juvastigmin Neoesserin Neostigmin Prostigmi 3-(n,n-dimethylcarbamoyloxy)-n,n,n,-trimethylanilinium bromide NEOSTIGMINEBROMIDE,USP NEOSTIGMINE BROMIDE(RG) synthostigminebromide syntostigmin(tablet) syntostigminbromide syntostigminebromide vagostigminebromide NEOSTIGMINE BROMIDE IRREVERSIBLE INHIBIT O 3-(N,N-Dimethylcarbamoyloxy)-N,N,N,-trimethylanilinium bromide, Prostigmine prostigmin PROSTIGMINE NEOSTIGIMINE BROMIDE NEOSTIGMINE BROMIDE (m-hydroxyphenyl)trimethyl-ammonium bromide dimethylcarbamate 3-(((dimethylamino)carbonyl)oxy)-n,n,n-trimethyl-benzenaminiubromide 3-[[Dmiethylamino)carbonyl]oxy]-N,N,N-trimethylbenzen-aminium 3-dimethylcarbamoxyphenyltrimethylammoniumbromide 3-hydroxyphenyltrimethylammoniumbromidedimethylcarbamicester Ammonium,(m-hydroxyphenyl)trimethyl-,bromide,dimethylcarbamate Benzenaminium,3-[[(dimethylamino)carbonyl]oxy]-N,N,N-trimethyl-,bromide(9CI) dimethyl-carbamicaciesterwith(m-hydroxyphenyl)trimethylammoniumbromi eustigminbromide kirkstigminebromide leostigminebromide neoserinebromide neostigminemethylbromide philostigminbromide proserinebromide prostigminbromide prostigminebromide rcrawastenumberu053 Synstigmine bromide Neostigmine bromide,99% Neostigmine Bromide (200 mg) 3-[(diMethylcarbaMoyl)oxy]-N,N,N-triMethylaniliniuM broMide NeostigMine broMide(ProstigMin) Neoeserine BroMide (3-Dimethylcarbamoyloxyphenyl)trimethylammonium Bromide (3-Hydroxyphenyl)trimethylammonium Bromide Dimethyl Carbamate 3-((diMethylcarbaMoyl)oxy)-N,N,N-triMethylbenzenaMiniuM broMide 3-[[(dimethylamino)carbonyl]oxy]-N,N,N-trimethyl-benzenaminium,bromide (1:1) Neostigmine bromide, 98%, a reversible acetylcholinesterase inhibitor Neostigmine BromideChemical Structure NeostigmineBromide> Neostigmine bromide CRS NeostigminiBromidum Neostigmine bromide USP/EP/BP