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ChemicalBook >> CAS DataBase List >>Econazole nitrate

Econazole nitrate

CAS No.
24169-02-6
Chemical Name:
Econazole nitrate
Synonyms
Pargin;Amicel;Micogin;Gynoryl;SQ 13050;Micofugal;e Nitrate;NSC 243115;Gyno-Pevaril;Gyno-prevaryl
CBNumber:
CB3173103
Molecular Formula:
C18H16Cl3N3O4
Molecular Weight:
444.7
MDL Number:
MFCD00058160
MOL File:
24169-02-6.mol
Last updated:2024-12-18 14:08:57

Econazole nitrate Properties

Melting point 162°C
storage temp. Inert atmosphere,Room Temperature
solubility chloroform/methanol: soluble25mg/mL (choloroform:methanol (1:1))
form powder
color white to off-white
Water Solubility <0.1 g/100 mL at 19 ºC
Merck 14,3502
InChIKey DDXORDQKGIZAME-UHFFFAOYSA-N
CAS DataBase Reference 24169-02-6(CAS DataBase Reference)
EWG's Food Scores 2
FDA UNII H438WYN10E
EPA Substance Registry System Econazole mononitrate (24169-02-6)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319
Precautionary statements  P264-P270-P280-P301+P312-P302+P352-P305+P351+P338
Hazard Codes  Xn,Xi
Risk Statements  22-36/38-36/37/38
Safety Statements  26-36-36/37
WGK Germany  3
RTECS  NI4450000
HS Code  29332900
Toxicity LD50 in mice, rats (mg/kg): 462.7, 667.7 orally (Thienpont)
NFPA 704
0
2 0

Econazole nitrate price More Price(30)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich E4632 Econazole nitrate salt 24169-02-6 5g $75.6 2024-03-01 Buy
Sigma-Aldrich E4632 Econazole nitrate salt 24169-02-6 25g $326 2024-03-01 Buy
TCI Chemical E0957 Econazole Nitrate >98.0%(HPLC)(T) 24169-02-6 5g $56 2024-03-01 Buy
TCI Chemical E0957 Econazole Nitrate >98.0%(HPLC)(T) 24169-02-6 25g $197 2024-03-01 Buy
Alfa Aesar J63173 Econazole nitrate 24169-02-6 5g $68 2024-03-01 Buy
Product number Packaging Price Buy
E4632 5g $75.6 Buy
E4632 25g $326 Buy
E0957 5g $56 Buy
E0957 25g $197 Buy
J63173 5g $68 Buy

Econazole nitrate Chemical Properties,Uses,Production

Description

Econazole nitrate is the nitrate salt form of Econazole. It belongs to imidazole-class antifungal medication sold in various places around the world including US, Canada, Western Europe, and Asia. It is usually manufactured into cream form for sale. Econazole nitrate is mainly used for the treatment of skin infections including athlete's foot, tinea, pityriasis versicolor, ringworm, and jock itch caused by fungi such as Trichophyton rubrum, Trichophyton tonsurans and Microsporum audouini. As an imidazole-class drug, Econazole nitrate takes effects through inhibiting the biosynthesis of ergosterol, a key component of fungal cell membrane, thus disrupting the normal permeability of fungal membrane. This causes leakage of essential cellular contents of fungi, further killing them.

References

http://www.rxlist.com/econazole-nitrate-cream-drug/clinical-pharmacology.htm
https://en.wikipedia.org/wiki/Econazole
http://www.pdr.net/drug-summary/Econazole-Nitrate-econazole-nitrate-731

Chemical Properties

White to Off-White Solid

Originator

Pevaryl,Cilag Chemie,France,1976

Uses

Azole antifungal

Uses

Antifungal;Ergosterol synthesis inhibition

Uses

Econazole nitrate is an antifungal agent of the imidazole type used in topical and vaginal preparations to prevent growth of dermatophytes, yeast, and mold.

Manufacturing Process

A suspension of 10.3 parts of α-(2,4-dichlorophenyl)-imidazole-1-ethanol and 2.1 parts of sodium hydride in 50 parts of dry tetrahydrofuran is stirred andrefluxed for 2 hours. After this reaction-time, the evolution of hydrogen is ceased. Then there are added successively 60 parts dimethylformamide and 8 parts of p-chlorobenzylchloride and stirring and refluxing is continued for another two hours. The tetrahydrofuran is removed at atmospheric pressure. The dimethylformamide solution is poured onto water. The product, 1-[2,4- dichloro-β-(p-chlorobenzyloxy)phenethyl]imidazole, is extracted with benzene. The extract is washed with water, dried, filtered and evaporated in vacuo. From the residual oily free base, the nitrate salt is prepared in the usual manner in 2-propanol by treatment with concentrated nitric acid, yielding, after recrystallization of the crude solid salt from a mixture of 2-propanol, methanol and diisopropylether, 1-[2,4-dichloro-β-(pchlorobenzyloxy)phenethyl]imidazole nitrate; MP 162°C.

brand name

Spectazole (Johnson & Johnson).

Therapeutic Function

Antifungal

General Description

White crystalline powder.

Air & Water Reactions

Insoluble in water.

Fire Hazard

Flash point data for Econazole nitrate are not available; however, Econazole nitrate is probably combustible.

Biochem/physiol Actions

Econazole interacts with 14-α demethylase, a cytochrome P-450 enzyme necessary to convert lanosterol to ergosterol. Inhibition of ergosterol results in increased cellular permeability causing leakage of cellular contents. Econazole may also inhibit endogenous respiration, interact with membrane phospholipids, inhibit the transformation of yeasts to mycelial forms, inhibit purine uptake, and impair triglyceride and phospholipid biosynthesis.

Econazole nitrate Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 321)Suppliers
Supplier Tel Email Country ProdList Advantage
Changzhou Rokechem Technology Co., Ltd. 		18758118018 sales001@rokechem.com China 255 58
Henan Bao Enluo International TradeCo.，LTD 		+86-17331933971 +86-17331933971 deasea125996@gmail.com China 2472 58
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21634 55
Hubei Jusheng Technology Co.,Ltd. 		18871490254 linda@hubeijusheng.com CHINA 28172 58
CONIER CHEM AND PHARMA LIMITED 		+8618523575427 sales@conier.com China 49374 58
career henan chemical co 		+86-0371-86658258 +8613203830695 factory@coreychem.com China 29811 58
WUHAN CIRCLE POWDER TECHNOLOGY CO.,LTD 		+8615377521700 wangwendy93@gmail.com China 868 58
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32161 58
Longyan Tianhua Biological Technology Co., Ltd 		0086 18039857276 18039857276 CHINA 2783 58
Hefei TNJ Chemical Industry Co.,Ltd. 		+86-0551-65418671 +8618949823763 sales@tnjchem.com China 34563 58

View Lastest Price from Econazole nitrate manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Econazole nitrate pictures 2024-12-13 Econazole nitrate
24169-02-6
 US $0.00 / KG 1KG 99%~101.0% 800kg/month WUHAN FORTUNA CHEMICAL CO., LTD
Econazole nitrate pictures 2024-11-19 Econazole nitrate
24169-02-6
 US $30.00 / mg 99% 10g TargetMol Chemicals Inc.
Econazole nitrate pictures 2024-11-19 Econazole nitrate
24169-02-6
 US $30.00 / mg 99% 10g TargetMol Chemicals Inc.

Econazole nitrate Spectrum

(RS)-1-[2,4-DICHLORO-BETA-(P-CHLOROBENZYLOXY)PHENETHYL]-IMIDAZOLE NITRATE 1-[2-[(4-chlorophenyl)methoxy]-2-(2,4-dichlorophenyl)ethyl]-1H-imidazolium nitrate ECONAZOLE NITRATE 99%-101% ECONAZOLE NITRATE ECONAZOLE NITRATE SALT ECONAZOL NITRATE 1-(2,4-dichloro-beta-((p-chlorobenzyl)oxy)phenethyl)imidazole nitrate 1-[2-[(4-chlorophenyl)methoxy]-2-(2,4-dichlorophenyl)-ethyl]-1h-imidazole mononitrate 1-[2-([4-CHLOROPHENYL]METHOXY)-2-(2,4-DICHLOROPHENYL)ETHYL]-1H-IMIDAZOLE NITRATE 1-[2-([4-CHLOROPHENYL]METHOXY)-2-(2,4-DICHLOROPHENYL)ETHYL]-1H-IMIDAZOLE NITRATE SALT 1H-Imidazole, 1-2-(4-chlorophenyl)methoxy-2-(2,4-dichlorophenyl)ethyl-, mononitrate 1-[2-(4-Chlorobenzyloxy)-2-(2,4-dichlorophenyl)ethyl]imidazole nitrate Gyno-Pevaril Imidazole, 1-[2,4-dichloro-β-[(p-chlorobenzyl)oxy]phenethyl]-, mononitrate (8CI) Micofugal Micogin NSC 243115 Pargin SQ 13050 1H-Imidazole, 1-(2-((4-chlorophenyl)methoxy)-2-(2,4-dichlorophenyl)ethyl)-, nitrate Gyno-prevaryl Amicel 1-[2-(4-chlorobenzyl)oxy-2-(2,4-dichlorophenyl)ethyl]imidazole 1-[2-[(4-chlorophenyl)methoxy]-2-(2,4-dichlorophenyl)ethyl]imidazole 1H-Imidazole, 1-[2-[(4-chlorophenyl)methoxy]-2-(2,4-dichlorophenyl)ethyl]-, nitrate (1:1) Econazole nitrate salt,1-(2-[(4-Chlorophenyl)methoxy]-2-[2,4-dichlorophenyl]ethyl)-1H-imidazole ECONAZOLENITRATE1% Econazole  Econazole nitrate (Spectazole) Gynoryl 1-(2-((4-chlorobenzyl)oxy)-2-(2,4-dichlorophenyl)ethyl)-1H-iMidazole nitrate 1-[2-[(4-chlorophenyl)methoxy]-2-(2,4-dichlorophenyl)ethyl]-1H-imidazole, nitrate (1:1) econazole nitrate:1-(2-((4-chlorophenyl)methoxy)-2-(2,4-dichlorophenyl)-ethyl)-1h-IMIDAZOLE mononitrate 1-(2-((2-chlorobenzyl)oxy)-2-(2,4-dichlorophenyl)ethyl)-1H-imidazole nitrate Econazole nitrate USP/EP/BP Econazole nitrate (NSC 243115 Bifonazole Solution, 100ppm Econazole nitrate, 98.5% EconazoleNitrate> e Nitrate 24169-02-6 Econazole Nitrate Miconazole EP Impurity B as Nitrate Miconazole Nitrate EP Impurity B as Nitrate C13101100 EconazolEnitrate 24169-02-6 24169-02-6;68797-31-9 C18H16Cl3N3O4 C18H14Cl3N2OHNO3 Aromatics Heterocycles Intermediates & Fine Chemicals Pharmaceuticals Spectazole Pyridines Aromatic Nitriles Organics ACTIVE PHARMACEUTICAL INGREDIENTS 24169-02-6