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ChemicalBook >> CAS DataBase List >>Ethanone, 2-[(3,5-dichlorophenyl)amino]-1-[(2R,3R)-2-methyl-3-(7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)-1-piperidinyl]-

Ethanone, 2-[(3,5-dichlorophenyl)amino]-1-[(2R,3R)-2-methyl-3-(7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)-1-piperidinyl]-

CAS No.
1374239-71-0
Chemical Name:
Ethanone, 2-[(3,5-dichlorophenyl)amino]-1-[(2R,3R)-2-methyl-3-(7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)-1-piperidinyl]-
Synonyms
BTK-IN-18;Ethanone, 2-[(3,5-dichlorophenyl)amino]-1-[(2R,3R)-2-methyl-3-(7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)-1-piperidinyl]-
CBNumber:
CB312985062
Molecular Formula:
C20H22Cl2N6O
Molecular Weight:
433.33
MDL Number:
MOL File:
1374239-71-0.mol
Last updated:2025-04-18 09:52:05

Ethanone, 2-[(3,5-dichlorophenyl)amino]-1-[(2R,3R)-2-methyl-3-(7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)-1-piperidinyl]- Properties

Density 1.442±0.06 g/cm3(Predicted)
pka 13.03±0.50(Predicted)

Ethanone, 2-[(3,5-dichlorophenyl)amino]-1-[(2R,3R)-2-methyl-3-(7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)-1-piperidinyl]- Chemical Properties,Uses,Production

Uses

BTK-IN-18 is a potent, reversible BTK inhibitor with an IC50 of 0.002 μM. BTK-IN-18 inhibits both CD69 and CD86 in vivo[1].

in vivo

BTK-IN-18 (compound 41; 10, 25, 45 mg/kg; IP; single dose) causes robust dose-dependent inhibition of both CD69 and CD86[1].
BTK-IN-18 (iv; 1 mg/kg) has a T1/2 of 5.3 hours, a CL of 19 mL/min/kg, and a Vss of 1.3 L/kg for rats[1].

Animal Model:Mice[1]
Dosage:10, 25, 45 mg/kg
Administration:IP; single dose
Result:Caused robust dose-dependent inhibition of both CD69 and CD86 (74.8 %, 50.3 %, and 21.5 % respectively).
Animal Model:
Dosage:
Administration:
Result:Pharmacokinetic Parameters of BTK-IN-18 in rats[1].
IV (1 mg/kg)PO (5 mg/kg)
Tmax (h)1.6
Cmax (h?mg/mL)321
AUCinfi (h?mg/mL)10131421
t1/2 (ng/mL)5.3
CL (mL/min/kg)19
Vss (L/kg)1.3
F (%)23%

References

[1] George H Vandeveer, et al. Discovery of structural diverse reversible BTK inhibitors utilized to develop a novel in vivo CD69 and CD86 PK/PD mouse model. Bioorg Med Chem Lett. 2022 Dec 17;80:129108. DOI:10.1016/j.bmcl.2022.129108

Ethanone, 2-[(3,5-dichlorophenyl)amino]-1-[(2R,3R)-2-methyl-3-(7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)-1-piperidinyl]- Preparation Products And Raw materials

Raw materials

Preparation Products

Ethanone, 2-[(3,5-dichlorophenyl)amino]-1-[(2R,3R)-2-methyl-3-(7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)-1-piperidinyl]- Suppliers

Global( 2)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc. 		+8613564774135 zijue.cai@tsbiochem.com United States 19897 58
TargetMol Chemicals Inc. 15002134094 marketing@targetmol.cn China 19820 58

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Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
BTK-IN-18 pictures 2024-11-19 BTK-IN-18
1374239-71-0
 US $3700.00-2780.00 / mg 10g TargetMol Chemicals Inc.
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  • BTK-IN-18
    1374239-71-0
  • US $3700.00-2780.00 / mg
  • TargetMol Chemicals Inc.
Ethanone, 2-[(3,5-dichlorophenyl)amino]-1-[(2R,3R)-2-methyl-3-(7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)-1-piperidinyl]- BTK-IN-18 1374239-71-0