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ChemicalBook >> CAS DataBase List >>Butanamide, 2-[(2-amino-9H-purin-6-yl)thio]-N-(4-hydroxy-3-methoxyphenyl)-

Butanamide, 2-[(2-amino-9H-purin-6-yl)thio]-N-(4-hydroxy-3-methoxyphenyl)-

CAS No.
2631703-41-6
Chemical Name:
Butanamide, 2-[(2-amino-9H-purin-6-yl)thio]-N-(4-hydroxy-3-methoxyphenyl)-
Synonyms
ENPP1 Inhibitor 43;Butanamide, 2-[(2-amino-9H-purin-6-yl)thio]-N-(4-hydroxy-3-methoxyphenyl)-
CBNumber:
CB312304865
Molecular Formula:
C16H18N6O3S
Molecular Weight:
374.42
MDL Number:
MOL File:
2631703-41-6.mol
Last updated:2025-04-17 18:22:24

Butanamide, 2-[(2-amino-9H-purin-6-yl)thio]-N-(4-hydroxy-3-methoxyphenyl)- Properties

Density 1.50±0.1 g/cm3(Predicted)
solubility DMSO: 1 mg/ml
form A crystalline solid
pka 9.24±0.10(Predicted)
color Off-white to gray

Butanamide, 2-[(2-amino-9H-purin-6-yl)thio]-N-(4-hydroxy-3-methoxyphenyl)- Chemical Properties,Uses,Production

Description

ENPP1 inhibitor 43 is an inhibitor of ectonucleotide pyrophosphatase/phosphodiesterase family member 1 (ENPP1; Ki = 41 nM).1 It inhibits tumor growth in an LLC1 murine lung cancer model when administered orally or intravenously at doses of 10 and 100 mg/kg, respectively.

Uses

Enpp-1-IN-12 (compound 43) is a potent and orally active ecto-nucleotide pyrophosphatase/phosphodiesterases 1 (ENPP1) inhibitor, with a Ki of 41 nM. Enpp-1-IN-12 exhibits anti-tumor activity[1].

in vivo

Enpp-1-IN-12 (100 mg/kg; p.o.) inhibits tumor growth in LLC1 syngeneic murine tumor model for lung cancer[1].
Enpp-1-IN-12 (10 mg/kg; p.o.) exhibits moderate oral bioavailability (F=45.1%), half-life (t1/2=1.04 h), and Cmax (303.10 ng/mL) in healthy female BALB/c mice[1].
Enpp-1-IN-12 (1 mg/kg; i.v.) exhibits half-life (t1/2=0.76 h), Cmax (308.64 ng/mL), and CL of 73.22 mL/min/kg in healthy female BALB/c mice[1].

References

1. Gangar, M., Goyal, S., Raykar, D., et al. Design, synthesis and biological evaluation studies of novel small molecule ENPP1 inhibitors for cancer immunotherapy Bioorg. Chem. 119,105549(2022).

Butanamide, 2-[(2-amino-9H-purin-6-yl)thio]-N-(4-hydroxy-3-methoxyphenyl)- Preparation Products And Raw materials

Raw materials

Preparation Products

Butanamide, 2-[(2-amino-9H-purin-6-yl)thio]-N-(4-hydroxy-3-methoxyphenyl)- Suppliers

Global( 6)Suppliers
Supplier Tel Email Country ProdList Advantage
Aladdin Scientific 		tp@aladdinsci.com United States 52924 58
Shanghai Yifei Biotechnology Co. , Ltd. 021-65675885 18964387627 customer_service@efebio.com China 11973 58
TargetMol Chemicals Inc. 15002134094 marketing@targetmol.cn China 19820 58
Cayman Chemical Company 800-364-9897 sales@caymanchem.com China 27736 58
Butanamide, 2-[(2-amino-9H-purin-6-yl)thio]-N-(4-hydroxy-3-methoxyphenyl)- ENPP1 Inhibitor 43 2631703-41-6