ChemicalBook >> CAS DataBase List >>10H,13H-Benzo[de]pyrano[3',4':6,7]indolizino[1,2-b]quinoline-10,13-dione, 9-ethyl-5-fluoro-1,2,3,9,12,15-hexahydro-9-hydroxy-4-methyl-, (9S)- (9CI)
10H,13H-Benzo[de]pyrano[3',4':6,7]indolizino[1,2-b]quinoline-10,13-dione, 9-ethyl-5-fluoro-1,2,3,9,12,15-hexahydro-9-hydroxy-4-methyl-, (9S)- (9CI)
![10H,13H-Benzo[de]pyrano[3',4':6,7]indolizino[1,2-b]quinoline-10,13-dione, 9-ethyl-5-fluoro-1,2,3,9,12,15-hexahydro-9-hydroxy-4-methyl-, (9S)- (9CI) Structure](CAS/20210305/GIF/210346-40-0.gif)
- CAS No.
- 210346-40-0
- Chemical Name:
- 10H,13H-Benzo[de]pyrano[3',4':6,7]indolizino[1,2-b]quinoline-10,13-dione, 9-ethyl-5-fluoro-1,2,3,9,12,15-hexahydro-9-hydroxy-4-methyl-, (9S)- (9CI)
- Synonyms
- Topoisomerase I inhibitor 8;10H,13H-Benzo[de]pyrano[3',4':6,7]indolizino[1,2-b]quinoline-10,13-dione, 9-ethyl-5-fluoro-1,2,3,9,12,15-hexahydro-9-hydroxy-4-methyl-, (9S)- (9CI)
- CBNumber:
- CB312012887
- Molecular Formula:
- C24H21FN2O4
- Molecular Weight:
- 420.43
- MDL Number:
- MOL File:
- 210346-40-0.mol
Last updated:2025-04-18 09:51:59
10H,13H-Benzo[de]pyrano[3',4':6,7]indolizino[1,2-b]quinoline-10,13-dione, 9-ethyl-5-fluoro-1,2,3,9,12,15-hexahydro-9-hydroxy-4-methyl-, (9S)- (9CI) Properties
| Melting point | 265 °C (decomp) |
|---|---|
| Boiling point | 807.3±65.0 °C(Predicted) |
| Density | 1.50±0.1 g/cm3(Predicted) |
| pka | 11.20±0.20(Predicted) |
| form | Solid |
| color | Light yellow to brown |
10H,13H-Benzo[de]pyrano[3',4':6,7]indolizino[1,2-b]quinoline-10,13-dione, 9-ethyl-5-fluoro-1,2,3,9,12,15-hexahydro-9-hydroxy-4-methyl-, (9S)- (9CI) Chemical Properties,Uses,Production
Uses
Topoisomerase I inhibitor 8 is a potent topoisomerase I inhibitor. Topoisomerase I inhibitor 8 is a hexacyclic analogue of camptothecin, and displays cytotoxic effect against tumor cells[1].
IC 50
Topoisomerase I
References
[1] Sugimori M, et al. Synthesis and antitumor activity of ring A- and F-modified hexacyclic camptothecin analogues. J Med Chem. 1998 Jun 18;41(13):2308-18. DOI:10.1021/jm970765q
10H,13H-Benzo[de]pyrano[3',4':6,7]indolizino[1,2-b]quinoline-10,13-dione, 9-ethyl-5-fluoro-1,2,3,9,12,15-hexahydro-9-hydroxy-4-methyl-, (9S)- (9CI) Preparation Products And Raw materials
Raw materials
Preparation Products
10H,13H-Benzo[de]pyrano[3',4':6,7]indolizino[1,2-b]quinoline-10,13-dione, 9-ethyl-5-fluoro-1,2,3,9,12,15-hexahydro-9-hydroxy-4-methyl-, (9S)- (9CI) Suppliers
Global( 4)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ShangHai Caerulum Pharma Discovery Co., Ltd. | 15000803246 18149758185 | sales-cpd@caerulumpharma.com | China | 382 | 58 |
| Nantong QuanYi Biotechnology Co., Ltd | 0513-66337626 18051384581 | sales@chemhifuture.com | China | 5528 | 58 |
| Nantong Hanfang Biotechnology Co. , Ltd. | hanfangpharma@126.com; 18616537568 | hanfangpharma@126.com | China | 29980 | 58 |
| TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 21356 | 58 |
10H,13H-Benzo[de]pyrano[3',4':6,7]indolizino[1,2-b]quinoline-10,13-dione, 9-ethyl-5-fluoro-1,2,3,9,12,15-hexahydro-9-hydroxy-4-methyl-, (9S)- (9CI)
Topoisomerase I inhibitor 8
210346-40-0