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ChemicalBook >> CAS DataBase List >>Ergosta-2,24-dien-26-oic acid, 5,6-epoxy-22,27-dihydroxy-1-oxo-4-[(2-pyridinylcarbonyl)oxy]-, δ-lactone, (4β,5β,6β,22R)-

Ergosta-2,24-dien-26-oic acid, 5,6-epoxy-22,27-dihydroxy-1-oxo-4-[(2-pyridinylcarbonyl)oxy]-, δ-lactone, (4β,5β,6β,22R)-

CAS No.
2690312-67-3
Chemical Name:
Ergosta-2,24-dien-26-oic acid, 5,6-epoxy-22,27-dihydroxy-1-oxo-4-[(2-pyridinylcarbonyl)oxy]-, δ-lactone, (4β,5β,6β,22R)-
Synonyms
ASR-490;Ergosta-2,24-dien-26-oic acid, 5,6-epoxy-22,27-dihydroxy-1-oxo-4-[(2-pyridinylcarbonyl)oxy]-, δ-lactone, (4β,5β,6β,22R)-
CBNumber:
CB310925640
Molecular Formula:
C34H41NO7
Molecular Weight:
575.7
MDL Number:
MOL File:
2690312-67-3.mol
Last updated:2025-04-18 09:52:04

Ergosta-2,24-dien-26-oic acid, 5,6-epoxy-22,27-dihydroxy-1-oxo-4-[(2-pyridinylcarbonyl)oxy]-, δ-lactone, (4β,5β,6β,22R)- Properties

Boiling point 760.1±60.0 °C(Predicted)
Density 1.30±0.1 g/cm3(Predicted)
pka 13.66±0.10(Predicted)
form Solid
color White to light yellow

Ergosta-2,24-dien-26-oic acid, 5,6-epoxy-22,27-dihydroxy-1-oxo-4-[(2-pyridinylcarbonyl)oxy]-, δ-lactone, (4β,5β,6β,22R)- Chemical Properties,Uses,Production

Uses

ASR-490 reduces the viability of HCT116 and SW620 cells by downregulating Notch1 signaling. ASR-490 overcomes Notch1 overexpression and inhibits the growth of HCT/Notch1 transfectants. ASR-490 inhibits the tumor growth in control (pCMV/HCT116) and Notch1/HCT116 in xenotransplanted mice[1].

in vivo

ASR-490 (5 mg/kg; i.p.; thrice a week for 4 weeks) inhibits the tumor growth in control (pCMV/HCT116) and Notch1/HCT116 in xenotransplanted mice[1].

Animal Model:Six- to 8-week-old BALB/c athymic nude mice (nu/nu) (pCMV/HCT116 and Notch1/HCT116 (C4) xenografts)[1].
Dosage:5 mg/kg
Administration:i.p., thrice a week for 4 weeks
Result:Inhibited the tumor growth in control (pCMV/HCT116) and Notch1/HCT116 in xenotransplanted mice.

References

[1] Tyagi A, et al. ASR490, a Small Molecule, Overrides Aberrant Expression of Notch1 in Colorectal Cancer. Mol Cancer Ther. 2020; 19(12):2422-2431. DOI:10.1158/1535-7163.MCT-19-0949

Ergosta-2,24-dien-26-oic acid, 5,6-epoxy-22,27-dihydroxy-1-oxo-4-[(2-pyridinylcarbonyl)oxy]-, δ-lactone, (4β,5β,6β,22R)- Preparation Products And Raw materials

Raw materials

Preparation Products

Ergosta-2,24-dien-26-oic acid, 5,6-epoxy-22,27-dihydroxy-1-oxo-4-[(2-pyridinylcarbonyl)oxy]-, δ-lactone, (4β,5β,6β,22R)- Suppliers

Global( 3)Suppliers
Supplier Tel Email Country ProdList Advantage
Aladdin Scientific 		tp@aladdinsci.com United States 52924 58
Aktin Chemicals, Inc. 028-85159085 info@aktinchem.com China 1860 58
Shanghai Yifei Biotechnology Co. , Ltd. 021-65675885 18964387627 customer_service@efebio.com China 11973 58
Ergosta-2,24-dien-26-oic acid, 5,6-epoxy-22,27-dihydroxy-1-oxo-4-[(2-pyridinylcarbonyl)oxy]-, δ-lactone, (4β,5β,6β,22R)- ASR-490 2690312-67-3