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ChemicalBook >> CAS DataBase List >>BLM-IN-1

BLM-IN-1

CAS No.
2056014-40-3
Chemical Name:
BLM-IN-1
Synonyms
BLM-IN-1;BLMIN1,BLM IN 1;(E)-6-((3-(Diethylamino)propyl)amino)-7-fluoro-3-(4-isopropylbenzylidene)-2,3-dihydropyrrolo[2,1-b]quinazolin-9(1H)-one;Pyrrolo[2,1-b]quinazolin-9(1H)-one, 6-[[3-(diethylamino)propyl]amino]-7-fluoro-2,3-dihydro-3-[[4-(1-methylethyl)phenyl]methylene]-, (3E)-
CBNumber:
CB25821211
Molecular Formula:
C28H35FN4O
Molecular Weight:
462.6
MDL Number:
MFCD32062677
MOL File:
2056014-40-3.mol
Last updated:2025-04-18 09:51:55

BLM-IN-1 Properties

Boiling point 630.0±65.0 °C(Predicted)
Density 1.16±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMSO : 8.33 mg/mL (18.01 mM; Need ultrasonic)
pka 10.33±0.25(Predicted)
form Solid
color Light yellow to yellow

BLM-IN-1 Chemical Properties,Uses,Production

Uses

BLM-IN-1 is an effective bloom syndrome protein (BLM) inhibitor. BLM-IN-1 has a high binding affinity with a KD valueof 1.81 μM. BLM-IN-1 has good inhibitory effect for BLM with an IC50 value of 0.95 μM. BLM-IN-1 can induce cell apoptosis. BLM-IN-1can be used for the research of DNA damage and cancer[1].

References

[1] Yin QK, et al. Discovery of Isaindigotone Derivatives as Novel Bloom's Syndrome Protein (BLM) Helicase Inhibitors That Disrupt the BLM/DNA Interactions and Regulate the Homologous Recombination Repair. J Med Chem. 2019 Mar 28;62(6):3147-3162. DOI:10.1021/acs.jmedchem.9b00083

BLM-IN-1 Preparation Products And Raw materials

Raw materials

Preparation Products

BLM-IN-1 Suppliers

Global( 14)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32239 58
TargetMol Chemicals Inc. 		support@targetmol.com United States 38648 58
TargetMol Chemicals Inc. 		+8613564774135 zijue.cai@tsbiochem.com United States 19897 58
BOC Sciences 1-631-485-4226; 16314854226 info@bocsci.com United States 12952 65
Shanghai Anyinuo Biomedical Technology Co., Ltd. 021-34625901 420970979@qq.com China 5848 58
Fan De(Beijing) Biotechnology Co., Ltd. 15911056312 liming@bio-fount.com China 9729 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 18818260767 sales@chemegen.com China 11218 58
Changzhou Furuisi Biotechnology Co., Ltd 0519-85524369 3477467573@qq.com China 8617 58
Shanghai Yifei Biotechnology Co. , Ltd. 021-65675885 18964387627 customer_service@efebio.com China 11973 58
RD International Technology Co., Limited 18024082417 market@ubiochem.com China 9835 58

View Lastest Price from BLM-IN-1 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
BLM-IN-1 pictures 2024-10-28 BLM-IN-1
2056014-40-3
 US $1860.00-2500.00 / mg 10g TargetMol Chemicals Inc.
  • BLM-IN-1 pictures
  • BLM-IN-1
    2056014-40-3
  • US $1860.00-2500.00 / mg
  • TargetMol Chemicals Inc.
BLM-IN-1 Pyrrolo[2,1-b]quinazolin-9(1H)-one, 6-[[3-(diethylamino)propyl]amino]-7-fluoro-2,3-dihydro-3-[[4-(1-methylethyl)phenyl]methylene]-, (3E)- BLMIN1,BLM IN 1 (E)-6-((3-(Diethylamino)propyl)amino)-7-fluoro-3-(4-isopropylbenzylidene)-2,3-dihydropyrrolo[2,1-b]quinazolin-9(1H)-one 2056014-40-3 C28H35FN4O